MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

Beyond Good and Evil: Molecular Mechanisms of Type I and III IFN Functions

(2022) Jack W. Dowling et al.   JOURNAL OF IMMUNOLOGY

Biological functions of DEAD/DEAH-box RNA helicases in health and disease

(2022) Ourania Andrisani et al.   NATURE IMMUNOLOGY

Walking a tightrope: The complex balancing act of R-loops in genome stability

(2022) Joshua R. Brickner et al.   MOLECULAR CELL

Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair

(2022) Joshua L. Justice et al.   TRENDS IN MICROBIOLOGY

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation

(2022) Agnese Cristini et al.   Nature Communications

DDX41 is required for cGAS-STING activation against DNA virus infection

(2022) Ravi Shankar Singh et al.   Cell Reports

DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice

(2022) Jing Ma et al.   Stem Cell Reports

Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

(2021) Joshua T. Weinreb et al.   DEVELOPMENTAL CELL

Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish

(2021) Joshua T. Weinreb et al.   HAEMATOLOGICA

Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice

(2021) Feng Xue et al.   NEUROBIOLOGY OF DISEASE

Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions

(2021) Kiwon Park et al.   PLoS Genetics

CellProfiler 4: improvements in speed, utility and usability

(2021) David R. Stirling et al.   BMC BIOINFORMATICS

Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia

(2021) Timothy M. Chlon et al.   Cell Stem Cell

Mechanisms of Antiviral Immune Evasion of SARS-CoV-2

(2021) Daniel K Beyer et al.   JOURNAL OF MOLECULAR BIOLOGY

ETV7 limits antiviral gene expression and control of influenza viruses

(2021) Heather M. Froggatt et al.   Science Signaling

Endomembrane targeting of human OAS1 p46 augments antiviral activity

(2021) Frank W Soveg et al.   eLife

DEAD-Box RNA Helicases and Genome Stability

(2021) Michael Cargill et al.   Genes

Regulation of IFN-Is by MEF2D Promotes Inflammatory Homeostasis in Microglia

(2021) Fangfang Lu et al.   Journal of Inflammation Research

Human DNA-PK activates a STING-independent DNA sensing pathway

(2020) Katelyn Burleigh et al.   Science Immunology

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response

(2020) Sandrine Ragu et al.   Genes

The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages

(2020) David M. Calcagno et al.   Science Immunology

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication

(2019) Orly Laufman et al.   CELL

Treatments in Aicardi–Goutières syndrome

(2019) Yanick J Crow et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

(2019) Dominick A. Matos et al.   MOLECULAR CELL

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions

(2019) Johannes Schwerk et al.   NATURE IMMUNOLOGY

Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors

(2019) Shahriyar P. Majidi et al.   Cell Reports

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

(2018) Liang Chen et al.   MOLECULAR CELL

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

(2018) Dongsung Kim et al.   NUCLEIC ACIDS RESEARCH

DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection

(2018) Spyridon Stavrou et al.   mBio

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

(2018) Prasun Chakraborty et al.   Nature Communications

From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections

(2018) Mahesh Chemudupati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors

(2017) Cody A. Desjardins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA–RNA hybrids: the risks of DNA breakage during transcription

(2017) Andrés Aguilera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

DNA–RNA hybrids: the risks of DNA breakage during transcription

(2017) Andrés Aguilera et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MEF2 signaling and human diseases

(2017) Xiao Chen et al.   Oncotarget

Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia

(2016) Moe Kadono et al.   EXPERIMENTAL HEMATOLOGY

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

(2016) Elizabeth E. Gray et al.   IMMUNITY

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

(2016) Caroline Townsend Stork et al.   eLife

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines

(2015) John J. Suschak et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Bruton’s Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response

(2015) Koon-Guan Lee et al.   Cell Reports

MDA5 Participates in the Detection of Paramyxovirus Infection and Is Essential for the Early Activation of Dendritic Cells in Response to Sendai Virus Defective Interfering Particles

(2014) J. S. Yount et al.   JOURNAL OF IMMUNOLOGY

Simian Virus 40 Large T Antigen Induces IFN-Stimulated Genes through ATR Kinase

(2014) A. Forero et al.   JOURNAL OF IMMUNOLOGY

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Transcription Factor Redundancy Ensures Induction of the Antiviral State

(2010) Sonja Schmid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE