Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy

(2020) Wenwen Li et al.   Science Translational Medicine

cGAS-STING pathway in oncogenesis and cancer therapeutics

(2020) Brandon Yi Da Hoong et al.   Oncotarget

Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming

(2020) Pengze Yan et al.   Cell Reports

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

(2020) Jenna M. Frame et al.   DEVELOPMENTAL CELL

A novel conditioning-free hematopoietic stem cell transplantation model in zebrafish

(2020) Ellen Fraint et al.   Blood Advances

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

Endothelial-to-haematopoietic transition: an update on the process of making blood

(2019) Katrin Ottersbach   BIOCHEMICAL SOCIETY TRANSACTIONS

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

(2019) Hui Jiang et al.   EMBO JOURNAL

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

Cyclic di-AMP in host–pathogen interactions

(2018) Laura Devaux et al.   CURRENT OPINION IN MICROBIOLOGY

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

(2018) Shelly Sorrells et al.   Disease Models & Mechanisms

Hematopoietic development: a gap in our understanding of inherited bone marrow failure

(2018) Peter Kurre   EXPERIMENTAL HEMATOLOGY

Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence

(2018) Raquel Espin-Palazon et al.   TRENDS IN CELL BIOLOGY

DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection

(2018) Spyridon Stavrou et al.   mBio

An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation

(2018) Tomasz Dobrzycki et al.   Biology Open

Human proteins that interact with RNA/DNA hybrids

(2018) Isabel X. Wang et al.   GENOME RESEARCH

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

(2018) Srivarsha Rajshekar et al.   eLife

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

zWEDGI: Wounding and Entrapment Device for Imaging Live Zebrafish Larvae

(2017) Kayla Huemer et al.   Zebrafish

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

(2015) C. Schinke et al.   BLOOD

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms

(2015) Chantana Polprasert et al.   CANCER CELL

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

(2015) Owen J. Tamplin et al.   CELL

Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish

(2015) Rui Ge et al.   JOURNAL OF VIROLOGY

Breaking bad: R-loops and genome integrity

(2015) Julie Sollier et al.   TRENDS IN CELL BIOLOGY

Bacterial c-di-GMP Affects Hematopoietic Stem/Progenitors and Their Niches through STING

(2015) Hiroshi Kobayashi et al.   Cell Reports

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

(2015) Yoong Wearn Lim et al.   eLife

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates

(2014) Q. He et al.   BLOOD

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

(2014) Michiel van der Vaart et al.   Cell Host & Microbe

Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence

(2014) Suphansa Sawamiphak et al.   DEVELOPMENTAL CELL

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

(2014) Arun K Mankan et al.   EMBO JOURNAL

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

(2014) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

(2014) Shihao Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning

(2013) Isabell Hess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Transgenic line with gal4 insertion useful to study morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development

(2012) Sohei Nakayama et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

(2012) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Microbial Colonization Induces Dynamic Temporal and Spatial Patterns of NF-κB Activation in the Zebrafish Digestive Tract

(2011) Michelle Kanther et al.   GASTROENTEROLOGY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

(2010) A Pellagatti et al.   LEUKEMIA

An Upstream Open Reading Frame and the Context of the Two AUG Codons Affect the Abundance of Mitochondrial and Nuclear RNase H1

(2010) Y. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols