A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state

(2022) Xiao-Qing Dai et al.   Cell Metabolism

Do oscillations in pancreatic islets require pacemaker cells?

(2022) Bradford E Peercy et al.   JOURNAL OF BIOSCIENCES

Computational Reconstruction of Pancreatic Islets as a Tool for Structural and Functional Analysis

(2022) Gerardo J. Félix-Martínez et al.   Jove-Journal of Visualized Experiments

Pancreatic α and β cells are globally phase-locked

(2022) Huixia Ren et al.   Nature Communications

From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science

(2022) Andraž Stožer et al.   Frontiers in Endocrinology

Ca2+ Oscillations, Waves, and Networks in Islets from Human Donors With and Without Type 2 Diabetes

(2022) Marko Gosak et al.   DIABETES

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

(2022) Vira Kravets et al.   PLOS BIOLOGY

Flipping the switch on the hub cell: Islet desynchronization through cell silencing

(2021) Janita P. Hogan et al.   PLoS One

The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on $${\text {Ca}}^{2+}$$ dynamics

(2021) Maryam Saadati et al.   Scientific Reports

Small subpopulations of β-cells do not drive islet oscillatory [Ca2+] dynamics via gap junction communication

(2021) JaeAnn M. Dwulet et al.   PLoS Computational Biology

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

(2021) Over Cabrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gap junction coupling and islet delta-cell function in health and disease

(2021) Caroline Miranda et al.   PEPTIDES

Autopoietic Influence Hierarchies in Pancreatic β Cells

(2021) Dean Korošak et al.   PHYSICAL REVIEW LETTERS

IsletLab: an application to reconstruct and analyze islet architectures

(2021) Gerardo J. Félix-Martínez   Islets

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet

(2020) Joely A. Kellard et al.   Molecular Metabolism

Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets

(2020) Berit Svendsen et al.   DIABETOLOGIA

Reconstructing human pancreatic islet architectures using computational optimization

(2020) Gerardo J. Félix-Martínez et al.   Islets

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

(2019) Elisa Vergari et al.   Nature Communications

Heterogeneity and Delayed Activation as Hallmarks of Self-Organization and Criticality in Excitable Tissue

(2019) Andraž Stožer et al.   Frontiers in Physiology

Biophysical modeling of β-cells networks: Realistic architectures and heterogeneity effects

(2019) A. Loppini et al.   BIOPHYSICAL CHEMISTRY

Electrophysiological models of the human pancreatic δ‐cell: From single channels to the firing of action potentials

(2019) Gerardo J. Félix‐Martínez et al.   International Journal for Numerical Methods in Biomedical Engineering

The somatostatin-secreting pancreatic δ-cell in health and disease

(2018) Patrik Rorsman et al.   Nature Reviews Endocrinology

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations

(2018) Chon-Lok Lei et al.   Islets

The α-cell in diabetes mellitus

(2018) Jesper Gromada et al.   Nature Reviews Endocrinology

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin

(2017) L. J. B. Briant et al.   JOURNAL OF PHYSIOLOGY-LONDON

Paracrine regulation of glucagon secretion: the β/α/δ model

(2016) Margaret Watts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Heterogeneity and nearest-neighbor coupling can explain small-worldness and wave properties in pancreatic islets

(2016) Giacomo Cappon et al.   CHAOS

Design Principles of Pancreatic Islets: Glucose-Dependent Coordination of Hormone Pulses

(2016) Danh-Tai Hoang et al.   PLoS One

Progressive glucose stimulation of islet beta cells reveals a transition from segregated to integrated modular functional connectivity patterns

(2015) Rene Markovič et al.   Scientific Reports

Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca2+ Wave Dynamics

(2014) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Dimensionality and Size Scaling of Coordinated Ca2+ Dynamics in MIN6 β-cell Clusters

(2014) Thomas H. Hraha et al.   BIOPHYSICAL JOURNAL

Phase transitions in pancreatic islet cellular networks and implications for type-1 diabetes

(2014) I. J. Stamper et al.   PHYSICAL REVIEW E

Mathematical models of electrical activity of the pancreatic β-cell: A physiological review

(2014) Gerardo J Félix-Martínez et al.   Islets

Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability

(2014) Thomas H. Hraha et al.   PLoS Computational Biology

Mathematical Modeling of Heterogeneous Electrophysiological Responses in Human β-Cells

(2014) Michela Riz et al.   PLoS Computational Biology

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

(2013) J. Li et al.   DIABETOLOGIA

Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

(2013) Andraž Stožer et al.   PLoS Computational Biology

Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin

(2012) A. C. Hauge-Evans et al.   DIABETOLOGIA

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

(2012) Andrei I. Tarasov et al.   PLoS One

Paracrine and autocrine interactions in the human islet: More than meets the eye

(2012) Alejandro Caicedo   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

(2011) Andreas Wiederkehr et al.   Cell Metabolism

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mapping Dynamic Protein Interactions to Insulin Secretory Granule Behavior with TIRF-FRET

(2010) Alice D. Lam et al.   BIOPHYSICAL JOURNAL

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in  -Cells Inhibits Glucagon Secretion From Human Islets

(2010) R. Ramracheya et al.   DIABETES

A mathematical model of β‐cells in an islet of Langerhans sensing a glucose gradient

(2010) Michael Meyer‐Hermann et al.   HFSP Journal

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells

(2009) M. Braun et al.   DIABETOLOGIA

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Systems of pancreatic beta-cells and glucose regulation

(2008) Hyuk Kang   Frontiers in Bioscience-Landmark

Wave-Block Due to a Threshold Gradient Underlies Limited Coordination in Pancreatic Islets

(2008) Morten Gram Pedersen et al.   JOURNAL OF BIOLOGICAL PHYSICS

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells

(2008) Salma T. Hanna et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation

(2008) Aparna Nittala et al.   Theoretical Biology and Medical Modelling