Beta-cell hubs maintain Ca2+ oscillations in human and mouse islet simulations

Investigation of the role of ion channels in human pancreatic β-cell hubs: A mathematical modeling study

(2018) Sajjad Farashi et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin

(2017) L. J. B. Briant et al.   JOURNAL OF PHYSIOLOGY-LONDON

Functional identification of islet cell types by electrophysiological fingerprinting

(2017) Linford J. B. Briant et al.   Journal of the Royal Society Interface

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

(2017) Julie Adam et al.   Cell Reports

Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells

(2017) Marko Gosak et al.   Frontiers in Physiology

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

(2017) Andrew R. Pepper et al.   Stem Cell Reports

Heterogeneity of the Pancreatic Beta Cell

(2017) Giselle Dominguez Gutierrez et al.   Frontiers in Genetics

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Insulin Action/Molecular Metabolism

(2016)   DIABETES

Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset

(2016) Chunguang Chen et al.   DIABETES

Changes in beta cell function occur in prediabetes and early disease in the Lepr db mouse model of diabetes

(2016) Oanh H. Do et al.   DIABETOLOGIA

Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles

(2015) Nora S. Kayton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Type 2 Diabetes–Associated K+Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

(2015) Nicholas C. Vierra et al.   DIABETES

Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca2+ Wave Dynamics

(2014) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Dimensionality and Size Scaling of Coordinated Ca2+ Dynamics in MIN6 β-cell Clusters

(2014) Thomas H. Hraha et al.   BIOPHYSICAL JOURNAL

Defects in  -Cell Ca2+ Dynamics in Age-Induced Diabetes

(2014) L. Li et al.   DIABETES

Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans

(2014) Nikki L. Farnsworth et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

A Conserved Rule for Pancreatic Islet Organization

(2014) Danh-Tai Hoang et al.   PLoS One

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

(2014) Richard K.P. Benninger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mathematical Modeling of Heterogeneous Electrophysiological Responses in Human β-Cells

(2014) Michela Riz et al.   PLoS Computational Biology

Supplements in Human Islet Culture: Human Serum Albumin is Inferior to Fetal Bovine Serum

(2013) Efstathios S. Avgoustiniatos et al.   CELL TRANSPLANTATION

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ

(2013) Jacques-Antoine Haefliger et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

(2013) Andraž Stožer et al.   PLoS Computational Biology

Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice

(2012) C. P. F. Carvalho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

(2012) A. V. Matveyenko et al.   DIABETES

Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

(2012) W. S. Head et al.   DIABETES

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes

(2011) B. A. Menge et al.   DIABETES

Time-dependent changes in membrane excitability during glucose-induced bursting activity in pancreatic β cells

(2011) Chae Young Cha et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ionic mechanisms and Ca2+dynamics underlying the glucose response of pancreatic β cells: a simulation study

(2011) Chae Young Cha et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Biophysical Model of Electrical Activity in Human β -Cells

(2010) Morten Gram Pedersen   BIOPHYSICAL JOURNAL

Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles

(2010) S. C. Collins et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

A Simplified Approach to Human Islet Quality Assessment

(2010) Matthew S. Hanson et al.   TRANSPLANTATION

Quantification of pancreatic islet distribution in situ in mice

(2009) German Kilimnik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

No mantle formation in rodent islets—The prototype of islet revisited

(2009) Michael Kharouta et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Autophagy Regulates Pancreatic Beta Cell Death in Response to Pdx1 Deficiency and Nutrient Deprivation

(2009) Kei Fujimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

(2008) Christophe A. Girard et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell coupling in mouse pancreatic  -cells measured in intact islets of Langerhans

(2008) Q. Zhang et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES