Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state

Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

(2021) Joshua Chiou et al.   NATURE GENETICS

Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states

(2021) Varun Bahl et al.   Molecular Metabolism

Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells

(2020) Vladimir Grubelnik et al.   Royal Society Open Science

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

(2020) Joan Camunas-Soler et al.   Cell Metabolism

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

(2020) Muhmmad Omar-Hmeadi et al.   Nature Communications

CytoMAP: A Spatial Analysis Toolbox Reveals Features of Myeloid Cell Organization in Lymphoid Tissues

(2020) Caleb R. Stoltzfus et al.   Cell Reports

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet

(2020) Joely A. Kellard et al.   Molecular Metabolism

Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

(2020) Katrina Viloria et al.   Cell Reports

ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity

(2020) Ebrahim H. Ghazvini Zadeh et al.   Cell Reports

Single cell transcriptomics of human islet ontogeny defines the molecular basis of β cell dedifferentiation in T2D

(2020) Dana Avrahami et al.   Molecular Metabolism

Repositioning the Alpha Cell in Postprandial Metabolism

(2020) Kimberley El et al.   ENDOCRINOLOGY

Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells

(2020) Tilo Moede et al.   Scientific Reports

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

(2019) Klaus H. Kaestner et al.   DIABETES

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Physiologic Implications of Reactive Oxygen Species Production by Mitochondrial Complex I Reverse Electron Transport

(2019) John O. Onukwufor et al.   Antioxidants

Highly Proliferative α-Cell–Related Islet Endocrine Cells in Human Pancreata

(2018) Carol J. Lam et al.   DIABETES

Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells

(2018) Mahdieh Godazgar et al.   JOURNAL OF PHYSIOLOGY-LONDON

α-cell glucokinase suppresses glucose-regulated glucagon secretion

(2018) Davide Basco et al.   Nature Communications

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

(2018) Jakob G. Knudsen et al.   Cell Metabolism

Functional identification of islet cell types by electrophysiological fingerprinting

(2017) Linford J. B. Briant et al.   Journal of the Royal Society Interface

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

(2016) Hongyan Shuai et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glucose control of glucagon secretion—‘There’s a brand-new gimmick every year’

(2016) Erik Gylfe   UPSALA JOURNAL OF MEDICAL SCIENCES

Glucagon secretion from pancreatic α-cells

(2016) Linford Briant et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types

(2015) Jin Li et al.   EMBO REPORTS

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

(2015) Mourad Ferdaoussi et al.   JOURNAL OF CLINICAL INVESTIGATION

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells

(2014) Xiao-Qing Dai et al.   JOURNAL OF PHYSIOLOGY-LONDON

Na+current properties in islet α- and β-cells reflect cell-specificScn3aandScn9aexpression

(2014) Quan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

(2013) Quan Zhang et al.   Cell Metabolism

UCP2 Regulates the Glucagon Response to Fasting and Starvation

(2013) E. M. Allister et al.   DIABETES

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

New calcium channel agonists as potential therapeutics in Lambert-Eaton myasthenic syndrome and other neuromuscular diseases

(2012) Tyler B. Tarr et al.   Annals of the New York Academy of Sciences

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Electrophysiological identification of mouse islet α-cells: From isolated single α-cells to in situ assessment within pancreas slices

(2011) Ya-Chi Huang et al.   Islets

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles

(2010) S. C. Collins et al.   DIABETES

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in  -Cells Inhibits Glucagon Secretion From Human Islets

(2010) R. Ramracheya et al.   DIABETES

Glucose Suppression of Glucagon Secretion

(2010) Sylvain J. Le Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unperturbed islet α-cell function examined in mouse pancreas tissue slices

(2010) Ya-Chi Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES