Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy

A Microenvironment Dual‐Responsive Nano‐Drug Equipped with PD‐L1 Blocking Peptide Triggers Immunogenic Pyroptosis for Prostate Cancer Self‐Synergistic Immunotherapy

(2023) He Wang et al.   ADVANCED FUNCTIONAL MATERIALS

ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy

(2023) Binbin Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity

(2023) Jing Lin et al.   Nature Communications

Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

(2022) Lisi Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Staggered Stacking Covalent Organic Frameworks for Boosting Cancer Immunotherapy

(2022) Liang Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Semiconducting Polymer Nanoparticles with Intramolecular Motion‐Induced Photothermy for Tumor Phototheranostics and Tooth Root Canal Therapy

(2022) Xingchen Duan et al.   ADVANCED MATERIALS

Glutathione Depletion‐Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor

(2022) Zhanwei Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

(2022) Jamie I. Scott et al.   Nature Communications

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

(2022) Nina Frey et al.   Nature Communications

Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy

(2022) Minglun Liu et al.   Nature Communications

Cu2+ Embedded Three-Dimensional Covalent Organic Framework for Multiple ROS-Based Cancer Immunotherapy

(2022) Xia Zhang et al.   ACS Applied Materials & Interfaces

Biodegradable Ca 2+ Nanomodulators Activate Pyroptosis through Mitochondrial Ca 2+ Overload for Cancer Immunotherapy

(2022) Pan Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy

(2022) Yang Yang et al.   Nature Communications

Activation of pyroptosis by specific organelle-targeting photodynamic therapy to amplify immunogenic cell death for anti-tumor immunotherapy

(2022) Shuang Zeng et al.   Bioactive Materials

Biomineralized Two‐Enzyme Nanoparticles Regulated Tumor Glycometabolism Inducing Tumor Cell Pyroptosis and Robust Anti‐Tumor Immunotherapy

(2022) Sijia Zhang et al.   ADVANCED MATERIALS

Radiofrequency-Activated Pyroptosis of Bi-Valent Gold Nanocluster for Cancer Immunotherapy

(2022) Qingqing Zhang et al.   ACS Nano

NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

(2021) Chencheng Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation

(2021) Min Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoscale Metal–Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy

(2021) Geoffrey T. Nash et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

The role of iron homeostasis in remodeling immune function and regulating inflammatory disease

(2021) Qingdian Mu et al.   Science Bulletin

Renal Clearable Ultrasmall Single-Crystal Fe Nanoparticles for Highly Selective and Effective Ferroptosis Therapy and Immunotherapy

(2021) Huan Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-Dimensional Covalent Organic Frameworks with Cross-Linked Pores for Efficient Cancer Immunotherapy

(2021) Liang Zhang et al.   NANO LETTERS

A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

(2021) Le‐Le Zhou et al.   Small

Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells

(2021) Liang Yan et al.   Frontiers in Pharmacology

Engineering Multienzyme‐Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

(2021) Liang Zhang et al.   ADVANCED MATERIALS

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

(2020) Binbin Ding et al.   ADVANCED MATERIALS

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

(2020) Evelyn Ploetz et al.   ADVANCED MATERIALS

Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

(2020) Shasha He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy

(2020) Yuyan Jiang et al.   Nature Communications

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

(2020) Mausita Karmakar et al.   Nature Communications

A Glycosylated Covalent Organic Framework Equipped with BODIPY and CaCO3 for Synergistic Tumor Therapy

(2020) Yu-Bin Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Na2S2O8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

(2020) Yang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light‐Triggered In Situ Gelation to Enable Robust Photodynamic‐Immunotherapy by Repeated Stimulations

(2019) Zhouqi Meng et al.   ADVANCED MATERIALS

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy

(2019) Liang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

(2018) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dendritic cells in cancer immunotherapy

(2018) Camille M. Le Gall et al.   NATURE MATERIALS

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

A Red Light Activatable Multifunctional Prodrug for Image-Guided Photodynamic Therapy and Cascaded Chemotherapy

(2016) Li-Han Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Aggregation-Induced Emission: Together We Shine, United We Soar!

(2015) Ju Mei et al.   CHEMICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE