A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

(2021) Bettina Weigelin et al.   Nature Communications

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis

(2021) Caterina Veroni et al.   Frontiers in Immunology

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET

(2021) Ning Zhao et al.   ACS Central Science

Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease

(2021) Alexander M. Pallazola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

On the Binding of Congo Red to Amyloid Fibrils

(2020) Alba Espargaró et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

(2020) Marta Canel et al.   eLife

T Cell Dysfunction and Exhaustion in Cancer

(2020) Zhen Zhang et al.   Frontiers in Cell and Developmental Biology

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

(2020) Tomasz Janiszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Near-Infrared Fluorescent Macromolecular Reporters for Real-Time Imaging and Urinalysis of Cancer Immunotherapy

(2020) Shasha He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Functional Chemiluminescent Probe for in vivo Imaging of Natural Killer Cell Activity against Tumours

(2020) Jamie Scott et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activatable Polymeric Nanoprobe for Near‐Infrared Fluorescence and Photoacoustic Imaging of T Lymphocytes

(2020) Yan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease

(2020) R Kalla et al.   Journal of Crohns & Colitis

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry

(2019) Matteo Guerra et al.   ACS Central Science

Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity

(2019) Quoc D. Mac et al.   Nature Biomedical Engineering

Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism

(2019) Clive Yik-Sham Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer

(2018) Takanori Kitamura et al.   Frontiers in Immunology

Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus

(2017) Helena M. Kok et al.   RHEUMATOLOGY

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths

(2016) Wioletta Rut et al.   BIOLOGICAL CHEMISTRY

An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells

(2016) Allegra T. Aron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril

(2016) Andreas Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Polymorphic Prion Protein β1 Peptides Reveal Variable Steric Zipper Conformations

(2015) Lu Yu et al.   BIOCHEMISTRY

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Imaging Granzyme B Activity Assesses Immune-Mediated MyocarditisNovelty and Significance

(2015) Masanori Konishi et al.   CIRCULATION RESEARCH

Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes

(2015) Pierre Mouchacca et al.   IMMUNOLOGY

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of a Series of Near-Infrared Dark Quenchers Based on Si-rhodamines and Their Application to Fluorescent Probes

(2015) Takuya Myochin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8+T-cell proliferation and survival

(2015) Rasha Abu Eid et al.   OncoImmunology

Spatially Resolved Monitoring of Neutrophil Elastase Activity with Ratiometric Fluorescent Reporters

(2012) Stefanie Gehrig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born

(2012) Andreas W. Götz et al.   Journal of Chemical Theory and Computation

In silico prediction of the granzyme B degradome

(2011) Lawrence JK Wee et al.   BMC GENOMICS

Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

(2011) Wei-Ting Hwang et al.   GYNECOLOGIC ONCOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Polyfunctional responses by human T cells result from sequential release of cytokines

(2011) Q. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma

(2009) Wendy Anne Boivin et al.   LABORATORY INVESTIGATION

Analysis of Protein Processing by N-terminal Proteomics Reveals Novel Species-specific Substrate Determinants of Granzyme B Orthologs

(2008) Petra Van Damme et al.   MOLECULAR & CELLULAR PROTEOMICS