Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity

CARD8 is an inflammasome sensor for HIV-1 protease activity

(2021) Qiankun Wang et al.   SCIENCE

Orf Virus ORF120 Protein Positively Regulates the NF-κB Pathway by Interacting with G3BP1

(2021) Yanlong Zhou et al.   JOURNAL OF VIROLOGY

An Orf Virus-based therapeutic vaccine for the treatment of papillomavirus-induced tumors

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Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Killer cells add fire to fuel immunotherapy

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An engineered oncolytic virus expressing PD-L1 inhibitors activates tumor neoantigen-specific T cell responses

(2020) Guan Wang et al.   Nature Communications

Orf Virus-Based Vaccine Vector D1701-V Induces Strong CD8+ T Cell Response against the Transgene but Not against ORFV-Derived Epitopes

(2020) Alena Reguzova et al.   Vaccines

Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis

(2020) Lori Bedient et al.   Viruses-Basel

Identification of in vitro and in vivo oncolytic effect in colorectal cancer cells by Orf virus strain NA1/11

(2020) Daxiang Chen et al.   ONCOLOGY REPORTS

Suppression of CCDC6 sensitizes tumor to oncolytic virus M1

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A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

(2019) Mengjiao Wu et al.   EBioMedicine

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

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Genomic characterization of two Orf virus isolates from Jilin province in China

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Oncolytic Newcastle disease virus reduces growth of cervical cancer cell by inducing apoptosis

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Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

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BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy

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Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

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Newcastle disease virus strain AF2240 as an oncolytic virus: A review

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Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

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Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy

(2018) Marie-Claude Bourgeois-Daigneault et al.   Science Translational Medicine

Novel chimeric parapoxvirus CF189 as an oncolytic immunotherapy in triple-negative breast cancer

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MEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation

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IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Immunogenicity of ORFV- based vectors expressing the rabies virus glycoprotein in livestock species

(2017) Mathias Martins et al.   VIROLOGY

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

(2017) Zuqiang Liu et al.   Nature Communications

A parapoxviral virion protein inhibits NF-κB signaling early in infection

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Microbiota-activated CD103+ DCs stemming from microbiota adaptation specifically drive γδT17 proliferation and activation

(2017) Chris Fleming et al.   Microbiome

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

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Oncolytic reovirus induces intracellular redistribution of Ras to promote apoptosis and progeny virus release

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Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells

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(2011) Caroline J. Breitbach et al.   NATURE

Orf Virus ORFV121 Encodes a Novel Inhibitor of NF- B That Contributes to Virus Virulence

(2010) D. G. Diel et al.   JOURNAL OF VIROLOGY

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

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