Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression

DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres

(2023) Aushaq B Malla et al.   EMBO REPORTS

DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression

(2023) Bismark Appiah et al.   EMBO REPORTS

Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells

(2023) Xin Zhao et al.   NUCLEIC ACIDS RESEARCH

DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome

(2022) Coral K. Wille et al.   Stem Cell Reports

Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains

(2022) Cristiana Bersaglieri et al.   Nature Communications

Mutant NPM1 hijacks transcriptional hub to maintain pathogenic gene programs in acute myeloid leukemia

(2022) Xue Qing David. Wang et al.   Cancer Discovery

Histone methyltransferase DOT1L controls state‐specific identity during B cell differentiation

(2021) Muhammad Assad Aslam et al.   EMBO REPORTS

The potential role of nucleophosmin (NPM1) in the development of cancer

(2021) Fateme Karimi Dermani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An EZH2‐dependent transcriptional complex promotes aberrant epithelial remodelling after injury

(2021) Huy Q Le et al.   EMBO REPORTS

DOT1L complex regulates transcriptional initiation in human erythroleukemic cells

(2021) Aiwei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Chaperone Nucleophosmin Regulates Transcription of Key Genes Involved in Oral Tumorigenesis

(2021) Parijat Senapati et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia

(2020) Yingyu Chen et al.   Therapeutic Advances in Hematology

Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

(2020) Wojciech Michowski et al.   MOLECULAR CELL

A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation

(2020) Yong Chi et al.   Science Advances

Architectural RNA in chromatin organization

(2020) Jitendra Thakur et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation

(2020) Kaixiang Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility

(2020) Francesco Ferrari et al.   Nature Communications

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer

(2020) R. Vatapalli et al.   Nature Communications

Transcriptional suppression of ribosomal DNA with phase separation

(2020) Satoru Ide et al.   Science Advances

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

(2019) Vijayalakshmi Kari et al.   Clinical Epigenetics

Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin

(2019) Anastassiia Vertii et al.   GENOME RESEARCH

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

(2019) Laura Godfrey et al.   Nature Communications

Differential contribution of steady‐state RNA and active transcription in chromatin organization

(2019) A Rasim Barutcu et al.   EMBO REPORTS

Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2

(2019) Long Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

(2018) Mikael S. Lindström et al.   ONCOGENE

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

(2018) Diana M. Mitrea et al.   Nature Communications

Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography

(2018) Gyosuke Sakashita et al.   Scientific Reports

Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing

(2018) Tianbao Li et al.   Genome Medicine

Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

(2018) Wu Zhang et al.   Theranostics

DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex

(2018) Henriette Franz et al.   NUCLEIC ACIDS RESEARCH

Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer

(2017) Xiaoxue Zhang et al.   Journal of Hematology & Oncology

Biological and clinical consequences of NPM1 mutations in AML

(2017) E M Heath et al.   LEUKEMIA

The upstreams and downstreams of H3K79 methylation by DOT1L

(2016) Hanneke Vlaming et al.   CHROMOSOMA

Regulation of Neuronal Survival by Nucleophosmin 1 (NPM1) Is Dependent on Its Expression Level, Subcellular Localization, and Oligomerization Status

(2016) Jason A. Pfister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update

(2016) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia

(2016) M. W. M. Ku hn et al.   Cancer Discovery

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

(2015) Guangchuang Yu et al.   BIOINFORMATICS

DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro

(2015) Deborah Roidl et al.   STEM CELLS

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties

(2015) Iris J. E. Stulemeijer et al.   Scientific Reports

AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

(2014) Aniruddha J. Deshpande et al.   CANCER CELL

DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation

(2014) P Cattaneo et al.   CELL DEATH AND DIFFERENTIATION

Loss of Nucleolar Histone Chaperone NPM1 Triggers Rearrangement of Heterochromatin and Synergizes with a Deficiency in DNA Methyltransferase DNMT3A to Drive Ribosomal DNA Transcription

(2014) Karl Holmberg Olausson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Conformations of Nucleophosmin (NPM1) at a Key Monomer-Monomer Interface Affect Oligomer Stability and Interactions with Granzyme B

(2014) Wei D. Duan-Porter et al.   PLoS One

Structural polymorphism in the N-terminal oligomerization domain of NPM1

(2014) D. M. Mitrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes of the Nucleolus Architecture in Absence of the Nuclear Factor CTCF

(2012) A. Hernández-Hernández et al.   CYTOGENETIC AND GENOME RESEARCH

Formation of nuclear heterochromatin

(2012) Claudio Guetg et al.   Epigenetics

Knockdown of NPM1 by RNA Interference Inhibits Cells Proliferation and Induces Apoptosis in Leukemic Cell Line

(2012) Feng-Xian Qin et al.   International Journal of Medical Sciences

Human Histone H3K79 Methyltransferase DOT1L Methyltransferase Binds Actively Transcribing RNA Polymerase II to Regulate Gene Expression

(2012) Seung-Kyoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Donor Lymphocyte Infusion Induces Polyspecific CD8+T-Cell Responses With Concurrent Molecular Remission in Acute Myeloid Leukemia WithNPM1Mutation

(2012) Susanne Hofmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1

(2011) R. Balusu et al.   BLOOD

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

The CCCTC-Binding Factor (CTCF) of Drosophila Contributes to the Regulation of the Ribosomal DNA and Nucleolar Stability

(2011) Paola A. Guerrero et al.   PLoS One

Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates

(2010) A. Koike et al.   CANCER RESEARCH

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

(2010) N. Buttner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the DOT1L Network: Implications of Diverse Roles for DOT1L

(2010) Geunyeong Park et al.   PROTEIN JOURNAL

Linking Cell Cycle to Histone Modifications: SBF and H2B Monoubiquitination Machinery and Cell-Cycle Regulation of H3K79 Dimethylation

(2009) Julia M. Schulze et al.   MOLECULAR CELL

ES Cell Cycle Progression and Differentiation Require the Action of the Histone Methyltransferase Dot1L

(2009) Evan R. Barry et al.   STEM CELLS

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY

Role of Npm1 in proliferation, apoptosis and differentiation of neural stem cells

(2007) Yang Qing et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES