Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 236, Issue 11, Pages 7832-7852Publisher
WILEY
DOI: 10.1002/jcp.30406
Keywords
cancer; NPM1; nucleophosmin; tumorigenesis; leukemia; solid tumors
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Nucleophosmin (NPM1) is a crucial nucleocytoplasmic shuttling protein involved in various cellular functions, and its dysregulation can contribute to cancer development. Research focuses on the gene and protein structure of NPM1 and its roles in cancer.
Nucleophosmin (NPM1) is a well-known nucleocytoplasmic shuttling protein that performs several cellular functions such as ribosome biogenesis, chromatin remodeling, genomic stability, cell cycle progression, and apoptosis. NPM1 has been identified to be necessary for normal cellular functions, and its altered regulation by overexpression, mutation, translocation, loss of function, or sporadic deletion can lead to cancer and tumorigenesis. In this review, we focus on the gene and protein structure of NPM1 and its physiological roles. Finally, we discuss the association of NPM1 with various types of cancer including solid tumors and leukemia.
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