The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay

(2018) Yakai Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

(2018) Eytan M. Stein et al.   BLOOD

The protective role of DOT1L in UV-induced melanomagenesis

(2018) Bo Zhu et al.   Nature Communications

Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing

(2018) Tianbao Li et al.   Genome Medicine

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

(2016) Vijayalakshmi Kari et al.   EMBO REPORTS

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer

(2015) Jochen Gaedcke et al.   Oncotarget

DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy

(2014) Wei Liu et al.   PLoS One

Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches

(2014) Felix Dietlein et al.   TRENDS IN GENETICS

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

(2013) S. R. Daigle et al.   BLOOD

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo

(2013) Melanie Spitzner et al.   INTERNATIONAL JOURNAL OF CANCER

Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

(2013) Valentyn Oksenych et al.   PLoS Genetics

Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases

(2012) Timothy P Wakeman et al.   EMBO JOURNAL

The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells

(2012) Oleksandra Karpiuk et al.   MOLECULAR CELL

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

The diverse functions of Dot1 and H3K79 methylation

(2011) A. T. Nguyen et al.   GENES & DEVELOPMENT

Genetic and Epigenetic Traits as Biomarkers in Colorectal Cancer

(2011) Marianne Berg et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation

(2011) D. White et al.   MOLECULAR CANCER RESEARCH

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

(2010) M.-J. Chang et al.   CANCER RESEARCH

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics