Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

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SONAR propels endothelin A receptor antagonists to success

(2019) Jennifer S. Pollock et al.   Nature Reviews Nephrology

Deacetylase activity-independent transcriptional activation by HDAC2 during TPA-induced HL-60 cell differentiation

(2018) Hyeonsoo Jung et al.   PLoS One

Blocking TGF-βandβ-Catenin Epithelial Crosstalk Exacerbates CKD

(2017) Stellor Nlandu-Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis

(2017) Hsi-Hua Chi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

(2016) C Dafflon et al.   LEUKEMIA

Plasma Pro-Endothelin-1 Peptide Concentrations Rise in Chronic Kidney Disease and Following Selective Endothelin A Receptor Antagonism

(2015) N. Dhaun et al.   Journal of the American Heart Association

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

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Aqp2-Expressing Cells Give Rise to Renal Intercalated Cells

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Aqp5 Is a New Transcriptional Target of Dot1a and a Regulator of Aqp2

(2013) Hongyu Wu et al.   PLoS One

Endothelin-1 and the kidney - beyond BP

(2012) Neeraj Dhaun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spironolactone Rescues Dot1a-Af9-Mediated Repression of Endothelin-1 and Improves Kidney Injury in Streptozotocin-Induced Diabetic Rats

(2012) Qiaoling Zhou et al.   PLoS One

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

(2012) Wenyu Yu et al.   Nature Communications

Genetics and CKD

(2011) V. Matti Vehaskari   ADVANCES IN CHRONIC KIDNEY DISEASE

Af17 Deficiency Increases Sodium Excretion and Decreases Blood Pressure

(2011) L. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AF17 Facilitates Dot1a Nuclear Export and Upregulates ENaC-Mediated Na+ Transport in Renal Collecting Duct Cells

(2011) Hongyu Wu et al.   PLoS One

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

(2010) M.-J. Chang et al.   CANCER RESEARCH

AF17 Competes with AF9 for Binding to Dot1a to Up-regulate Transcription of Epithelial Na+Channel α

(2009) Mary Rose Reisenauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple loci associated with indices of renal function and chronic kidney disease

(2009) Anna Köttgen et al.   NATURE GENETICS

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Osmotic polyuria: an overlooked mechanism in diabetic nephropathy

(2008) S. Wang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Reversal of proteinuric renal disease and the emerging role of endothelin

(2008) Matthias Barton   Nature clinical practice. Nephrology