Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment

Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump

(2023) Zhemin Zhang et al.   mBio

An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition

(2022) Jerzy Witwinowski et al.   Nature Microbiology

A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice

(2022) Jamie L. Dombach et al.   PLoS Pathogens

Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes

(2022) Joseph A. Villanueva et al.   mBio

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

(2021) Dani A. C. Heesterbeek et al.   PLoS Pathogens

Noc Corrals Migration of FtsZ Protofilaments during Cytokinesis in Bacillus subtilis

(2021) Yuanchen Yu et al.   mBio

Bacterial efflux transporters’ polyspecificity – a gift and a curse?

(2021) Helen I Zgurskaya et al.   CURRENT OPINION IN MICROBIOLOGY

Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of Escherichia coli Thymidylate Kinase In Vivo

(2021) Elizabeth T. Montaño et al.   JOURNAL OF BACTERIOLOGY

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa

(2021) Johanna Ude et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery

(2021) David J. Wooten et al.   Nature Communications

Charting the Fragmented Landscape of Drug Synergy

(2020) Christian T. Meyer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Infection-based chemical screens uncover host–pathogen interactions

(2020) Corrella S Detweiler   CURRENT OPINION IN MICROBIOLOGY

The Min System Disassembles FtsZ Foci and Inhibits Polar Peptidoglycan Remodeling in Bacillus subtilis

(2020) Yuanchen Yu et al.   mBio

Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance

(2020) Meinan Lyu et al.   mBio

Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice

(2020) Toni A. Nagy et al.   ACS Infectious Diseases

Antibiotics and Innate Immunity: A Cooperative Effort Towards the Successful Treatment of Infections

(2020) Andrew Berti et al.   Open Forum Infectious Diseases

A How-To Guide for Mode of Action Analysis of Antimicrobial Peptides

(2020) Ann-Britt Schäfer et al.   Frontiers in Cellular and Infection Microbiology

Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition

(2020) Najwa Taib et al.   Nature Ecology & Evolution

Human guanylate binding proteins: nanomachines orchestrating host defense

(2020) Miriam Kutsch et al.   FEBS Journal

A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids

(2020) Jamie L. Dombach et al.   PLoS Pathogens

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

(2019) Michael J. Ellis et al.   Nature Communications

Quantifying Drug Combination Synergy along Potency and Efficacy Axes

(2019) Christian T. Meyer et al.   Cell Systems

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

(2019) Chih-Chia Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Stoichiometry of FliW-CsrA Governs Flagellin Homeostasis and Cytoplasmic Organization in Bacillus subtilis

(2019) R. T. Oshiro et al.   mBio

Permeability barriers of Gram-negative pathogens

(2019) Helen I. Zgurskaya et al.   Annals of the New York Academy of Sciences

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump

(2019) Chih-Chia Su et al.   mBio

How the Membrane Attack Complex Damages the Bacterial Cell Envelope and Kills Gram‐Negative Bacteria

(2019) Dennis J. Doorduijn et al.   BIOESSAYS

A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load

(2018) Abigail L. Reens et al.   PLoS Pathogens

Crystal structures of theBurkholderia multivoranshopanoid transporter HpnN

(2017) Nitin Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hydrophobic trap—the Achilles heel of RND efflux pumps

(2017) Zachary Aron et al.   RESEARCH IN MICROBIOLOGY

Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division

(2017) Alexandre W. Bisson-Filho et al.   SCIENCE

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump

(2017) Chih-Chia Su et al.   Nature Communications

The Accidental Orthodoxy of Drs. Mueller and Hinton

(2017) Victor Nizet   EBioMedicine

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

(2016) Hanno Sjuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

(2015) Son T. Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

(2014) Jani Reddy Bolla et al.   PLoS One

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

(2013) Timothy J. Opperman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Some Ligands Enhance the Efflux of Other Ligands by the Escherichia coli Multidrug Pump AcrB

(2013) Alfred D. Kinana et al.   BIOCHEMISTRY

The ABC-Type Efflux Pump MacAB Protects Salmonella enterica serovar Typhimurium from Oxidative Stress

(2013) L. M. Bogomolnaya et al.   mBio

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli

(2011) Chih-Chia Su et al.   NATURE

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport

(2010) Feng Long et al.   NATURE

Membrane potential is important for bacterial cell division

(2010) H. Strahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of amine accumulation in, and egress from, lysosomes

(2010) Stephen DB Goldman et al.   Bioanalysis

The Bacterial Cell Envelope

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Role of Ceftiofur in Selection and Dissemination of blaCMY-2-Mediated Cephalosporin Resistance in Salmonella enterica and Commensal Escherichia coli Isolates from Cattle

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Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella

(2009) Kunihiko Nishino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Resistance against antimicrobial peptides is independent of Escherichia coli AcrAB, Pseudomonas aeruginosa MexAB and Staphylococcus aureus NorA efflux pumps

(2008) Siegbert Rieg et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

MinJ (YvjD) is a topological determinant of cell division inBacillus subtilis

(2008) Joyce E. Patrick et al.   MOLECULAR MICROBIOLOGY