A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

(2017) Xuan Wang-Kan et al.   mBio

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump

(2017) Chih-Chia Su et al.   Nature Communications

Interaction of Antibiotics with Innate Host Defense Factors against Salmonella enterica Serotype Newport

(2017) George Sakoulas et al.   mSphere

An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

(2016) Sofia Santos Costa et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA

(2016) Sarah E. McQuate et al.   CELLULAR MICROBIOLOGY

Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages

(2016) Sweta Samantaray et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation

(2016) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

(2016) Hanno Sjuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity

(2016) Mark D. Mathew et al.   PLoS Neglected Tropical Diseases

Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

(2015) Son T. Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Importance of Real-Time Assays To Distinguish Multidrug Efflux Pump-Inhibiting and Outer Membrane-Destabilizing Activities in Escherichia coli

(2015) Rajeev Misra et al.   JOURNAL OF BACTERIOLOGY

Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology

(2015) Jani Reddy Bolla et al.   Nature Communications

Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps

(2015) Chih-Chia Su et al.   Cell Reports

Multidrug Efflux Pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus Bacterial Food Pathogens

(2015) Jody Andersen et al.   International Journal of Environmental Research and Public Health

RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

(2015) Henrietta Venter et al.   Frontiers in Microbiology

Recent advances toward a molecular mechanism of efflux pump inhibition

(2015) Timothy J. Opperman et al.   Frontiers in Microbiology

Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens

(2015) Leo Lin et al.   EBioMedicine

Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

(2014) Attilio V. Vargiu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

(2014) Jan Rybniker et al.   Cell Host & Microbe

Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection

(2014) Claire Maudet et al.   Nature Communications

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

(2013) Timothy J. Opperman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Ferric Enterobactin Transporter Fep Is Required for Persistent Salmonella enterica Serovar Typhimurium Infection

(2013) Toni A. Nagy et al.   INFECTION AND IMMUNITY

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

The ABC-Type Efflux Pump MacAB Protects Salmonella enterica serovar Typhimurium from Oxidative Stress

(2013) L. M. Bogomolnaya et al.   mBio

Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression

(2012) Gernot Fritsche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Microfluidic Device for Simple and Rapid Evaluation of Multidrug Efflux Pump Inhibitors

(2012) Ryota Iino et al.   Frontiers in Microbiology

Systematic error detection in experimental high-throughput screening

(2011) Plamen Dragiev et al.   BMC BIOINFORMATICS

Regulation of Cathelicidin Antimicrobial Peptide Expression by an Endoplasmic Reticulum (ER) Stress Signaling, Vitamin D Receptor-independent Pathway

(2011) Kyungho Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Multidrug Efflux Pump Inhibitors by a New Method Using Microfluidic Channels

(2011) Yoshimi Matsumoto et al.   PLoS One

Optimized Nile Red Efflux Assay of AcrAB-TolC Multidrug Efflux System Shows Competition between Substrates

(2010) J. A. Bohnert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

(2010) Jacqueline Chevalier et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium

(2010) Tsukasa Horiyama et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli

(2010) N. G. Coldham et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase

(2010) Ryan C. Durk et al.   PLoS One

High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling

(2010) Priscille Brodin et al.   PLoS Pathogens

Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents againstHelicobacter pyloriInfection

(2009) Nunilo Cremades et al.   ACS Chemical Biology

Role of Ceftiofur in Selection and Dissemination of blaCMY-2-Mediated Cephalosporin Resistance in Salmonella enterica and Commensal Escherichia coli Isolates from Cattle

(2009) J. B. Daniels et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Regulation and physiological function of multidrug efflux pumps in Escherichia coli and Salmonella

(2009) Kunihiko Nishino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Slc11a1 limits intracellular growth ofSalmonella entericasv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition

(2009) Manfred Nairz et al.   CELLULAR MICROBIOLOGY

Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4

(2009) Londa J. Berghaus et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli

(2009) Laura Paixão et al.   Journal of Biological Engineering

A Small-Molecule Screen Identifies the Antipsychotic Drug Pimozide as an Inhibitor of Listeria monocytogenes Infection

(2008) L. A. Lieberman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES