Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance

Rationale for a Neisseria gonorrhoeae Susceptible–only Interpretive Breakpoint for Azithromycin

(2019) Ellen N Kersh et al.   CLINICAL INFECTIOUS DISEASES

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump

(2019) Chih-Chia Su et al.   mBio

Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein

(2019) Mohsen Chitsaz et al.   mBio

Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant

(2019) Yehuda Halfon et al.   Scientific Reports

Persistence of an outbreak of gonorrhoea with high-level resistance to azithromycin in England, November 2014‒May 2018

(2018) Christa Smolarchuk et al.   Eurosurveillance

Neisseria gonorrhoeae host adaptation and pathogenesis

(2018) Sarah Jane Quillin et al.   NATURE REVIEWS MICROBIOLOGY

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae

(2018) Crista B. Wadsworth et al.   mBio

Mosaic Drug Efflux Gene Sequences from Commensal Neisseria Can Lead to Low-Level Azithromycin Resistance Expressed by Neisseria gonorrhoeae Clinical Isolates

(2018) William M. Shafer   mBio

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus

(2018) Corinne E. Rouquette-Loughlin et al.   mBio

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump

(2017) Chih-Chia Su et al.   Nature Communications

Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB

(2016) Sabine Schuster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate

(2016) Abdessamad Ababou et al.   PLoS One

On the in vivo significance of bacterial resistance to antimicrobial peptides

(2015) Margaret E. Bauer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting

(2015) Lori Newman et al.   PLoS One

Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future

(2014) M. Unemo et al.   CLINICAL MICROBIOLOGY REVIEWS

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

(2014) Hsiang-Ting Lei et al.   PLoS One

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

(2014) Jani Reddy Bolla et al.   PLoS One

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa

(2009) Gaby Sennhauser et al.   JOURNAL OF MOLECULAR BIOLOGY

Clinically relevant mutations that cause derepression of theNeisseria gonorrhoeaeMtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance andin vivofitness

(2008) Douglas M. Warner et al.   MOLECULAR MICROBIOLOGY