Lysosomes in retinal health and disease

Mitochondrial-Derived Vesicles—Link to Extracellular Vesicles and Implications in Cardiovascular Disease

(2023) Jonas Heyn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes

(2023) Vicki J. Swier et al.   Disease Models & Mechanisms

Potential Role of the mTORC1-PGC1α-PPARα Axis under Type-II Diabetes and Hypertension in the Human Heart

(2023) Tianyu Hang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease

(2023) Fahad Mubariz et al.   Frontiers in Neuroscience

Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells

(2023) Kevin R. Zhang et al.   Disease Models & Mechanisms

Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens

(2023) Juan Ignacio Jiménez-Loygorri et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

(2022) Chenglong Xie et al.   Nature Biomedical Engineering

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD

(2022) Urvi Gupta et al.   Autophagy

Autophagy in age-related macular degeneration

(2022) Kai Kaarniranta et al.   Autophagy

Intravitreal gene therapy restores the autophagy-lysosomal pathway and attenuates retinal degeneration in cathepsin D-deficient mice

(2022) Junling Liu et al.   NEUROBIOLOGY OF DISEASE

The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up

(2022) Myoung Sup Shim et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The effect of A2E on lysosome membrane permeability during blue light-induced human RPEs apoptosis

(2022) Yan Xu et al.   BMC Ophthalmology

Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction

(2022) Kimberlee P. Giffen et al.   Science Advances

Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration

(2022) Ignacio Ramírez-Pardo et al.   Autophagy

Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity

(2022) Sayantan Datta et al.   Autophagy

Correction: Hydroxychloroquine Causes Early Inner Retinal Toxicity and Affects Autophagosome–Lysosomal Pathway and Sphingolipid Metabolism in the Retina

(2022) Koushik Mondal et al.   MOLECULAR NEUROBIOLOGY

DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium

(2022) Jiyang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration

(2022) Raquel Gomez-Sintes et al.   Nature Communications

Induction of Autophagy Promotes Clearance of RHOP23H Aggregates and Protects From Retinal Degeneration

(2022) Daniela Intartaglia et al.   Frontiers in Aging Neuroscience

mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases

(2022) Yipin Wang et al.   Antioxidants

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection

(2022) Christopher M. Richards et al.   SCIENCE

Microglia–Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model

(2022) Maeve Boyce et al.   Cells

A vicious cycle of bisretinoid formation and oxidation relevant to recessive Stargardt disease

(2021) Jin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism

(2021) Masaaki Ishii et al.   Frontiers in Immunology

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

(2021) Mathieu Paquette et al.   Autophagy

Common Principles and Specific Mechanisms of Mitophagy from Yeast to Humans

(2021) Rajesh Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysosome biogenesis: Regulation and functions

(2021) Chonglin Yang et al.   JOURNAL OF CELL BIOLOGY

Rapamycin activates mitophagy and alleviates cognitive and synaptic plasticity deficits in a mouse model of Alzheimer’s disease

(2021) Hui Wang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation

(2021) Cansu Karabiyik et al.   Autophagy

HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway

(2021) Lujia Feng et al.   Autophagy

Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy

(2021) Christina G. Towers et al.   DEVELOPMENTAL CELL

Mitochondrial fusion and fission: The fine‐tune balance for cellular homeostasis

(2021) Mary Adebayo et al.   FASEB JOURNAL

Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism

(2021) Xavier Leray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

(2021) Saumil Sethna et al.   Nature Communications

βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells

(2021) Peng Shang et al.   Communications Biology

Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization

(2021) Chendong Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy

(2021) Xi-Yuan Liu et al.   Frontiers in Neuroscience

Emerging Lysosomal Functions for Photoreceptor Cell Homeostasis and Survival

(2021) Manuela Santo et al.   Cells

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

(2020) Jingyue Jia et al.   MOLECULAR CELL

Retinal Degeneration in MPS-IIIA Mouse Model

(2020) Daniela Intartaglia et al.   Frontiers in Cell and Developmental Biology

The Role of Autophagy in Glaucomatous Optic Neuropathy

(2020) Annagrazia Adornetto et al.   Frontiers in Cell and Developmental Biology

Light‐responsive microRNA miR‐211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance

(2020) Federica Naso et al.   EMBO JOURNAL

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

(2020) Kai Kaarniranta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

(2020) Anders P. Mutvei et al.   Nature Communications

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance

(2020) Sinsuk Han et al.   EMBO REPORTS

Pharmacological clearance of misfolded rhodopsin for the treatment of RHO ‐associated retinitis pigmentosa

(2020) Xujie Liu et al.   FASEB JOURNAL

Age related retinal Ganglion cell susceptibility in context of autophagy deficiency

(2020) Katharina Bell et al.   Cell Death Discovery

p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth

(2020) Ada Nowosad et al.   NATURE CELL BIOLOGY

Complement modulation reverses pathology in Y402H ‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function

(2020) Edvinas Cerniauskas et al.   Stem Cells Translational Medicine

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

(2019) Leeanna El-Houjeiri et al.   Cell Reports

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

(2019) Lorena Fernandez-Mosquera et al.   Autophagy

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

(2019) King Faisal Yambire et al.   eLife

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV

(2019) Jin Young Yang et al.   Cell Communication and Signaling

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

(2019) Caterina Collodet et al.   FASEB JOURNAL

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

(2019) Shoji Notomi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype

(2019) Yevgeniya Atiskova et al.   Scientific Reports

Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells

(2019) April Nettesheim et al.   Scientific Reports

Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

(2018) Parisa Lotfi et al.   Autophagy

Mitochondrial cAMP-PKA signaling: What do we really know?

(2018) Yasmine Ould Amer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria

(2018) Matthew T. Sorbara et al.   Cell Host & Microbe

Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling

(2018) Christina M. McGuire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

(2018) Jie Wang et al.   Nature Communications

Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing

(2018) Guang Xu et al.   Autophagy

Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy

(2018) Shuyi Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration

(2018) Gulpreet Kaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

(2018) Szabolcs Felszeghy et al.   Redox Biology

mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy

(2017) Rosa Bartolomeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration

(2017) Sayan Ghosh et al.   JOURNAL OF PATHOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium

(2016) Debasish Sinha et al.   EXPERIMENTAL EYE RESEARCH

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system

(2016) Gian-Luca McLelland et al.   JOURNAL OF CELL BIOLOGY

Molecular basis for photoreceptor outer segment architecture

(2016) Andrew F.X. Goldberg et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Photoreceptor disc shedding in the living human eye

(2016) Omer P. Kocaoglu et al.   Biomedical Optics Express

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Autophagy in axonal degeneration in glaucomatous optic neuropathy

(2015) Yasunari Munemasa et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

(2015) Mario de la Mata et al.   Scientific Reports

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

(2014) Mallika Valapala et al.   Autophagy

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival

(2014) Elite Possik et al.   PLoS Genetics

Fundus Autofluorescence and RPE Lipofuscin in Age-Related Macular Degeneration

(2014) Janet Sparrow et al.   Journal of Clinical Medicine

Balance between autophagic pathways preserves retinal homeostasis

(2013) Natalia Rodríguez-Muela et al.   AGING CELL

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Lipofuscin: formation, effects and role of macroautophagy

(2013) Annika Höhn et al.   Redox Biology

Lysosomal dysfunction in neurodegeneration

(2012) Marija Usenovic et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin

(2012) Emeline F. Nandrot et al.   BIOLOGY OF THE CELL

Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase

(2012) Yingyu Mao et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

(2012) Sang Gyun Kim et al.   MOLECULAR CELL

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Retinitis Pigmentosa: Genes and Disease Mechanisms

(2011) Francesco Parmeggiani et al.   CURRENT GENOMICS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Ezrin Promotes Actin Assembly at the Phagosome Membrane and Regulates Phago-Lysosomal Fusion

(2011) Sabrina Marion et al.   TRAFFIC

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

(2009) Paloma B. Liton et al.   Autophagy

Mitochondrial Ca2+ homeostasis in lysosomal storage diseases

(2008) K KISELYOV et al.   CELL CALCIUM

Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells

(2008) Tuomas Ryhänen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Special delivery from mitochondria to peroxisomes

(2008) Uwe Schumann et al.   TRENDS IN CELL BIOLOGY