Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

(2014) Marie Stampe Ostenfeld et al.   Autophagy

VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy

(2013) Nivetha Ramachandran et al.   ACTA NEUROPATHOLOGICA

It’s a Cell-Eat-Cell World

(2013) Elizabeth A. Oczypok et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

Noncanonical Autophagy Promotes the Visual Cycle

(2013) Ji-Young Kim et al.   CELL

Lipid Droplets, Perilipins and Cytokeratins – Unravelled Liaisons in Epithelium-Derived Cells

(2013) Hans Heid et al.   PLoS One

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

(2013) Johanna Viiri et al.   PLoS One

Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes

(2013) Mallika Valapala et al.   Nature Communications

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts

(2012) M. Tatti et al.   HUMAN MOLECULAR GENETICS

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina

(2012) L. Ruggiero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

βA3/A1-crystallin is required for proper astrocyte template formation and vascular remodeling in the retina

(2012) Debasish Sinha et al.   TRANSGENIC RESEARCH

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

A novel melano-lysosome in the retinal epithelium of rhesus monkeys

(2011) Peter Gouras et al.   EXPERIMENTAL EYE RESEARCH

A competitive hexapeptide inhibitor of annexin A2 prevents hypoxia-induced angiogenic events

(2011) M. Valapala et al.   JOURNAL OF CELL SCIENCE

Mutation in the  A3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat

(2011) J. S. Zigler et al.   JOURNAL OF CELL SCIENCE

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis

(2011) B Ma et al.   Cell Death & Disease

Regulation and Isoform Function of the V-ATPases

(2010) Masashi Toei et al.   BIOCHEMISTRY

Ultra-fast FFT protein docking on graphics processors

(2010) David W. Ritchie et al.   BIOINFORMATICS

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The Retinal Pigment Epithelium in Health and Disease

(2010) J. R. Sparrrow et al.   CURRENT MOLECULAR MEDICINE

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Phagocytosis of Retinal Rod and Cone Photoreceptors

(2010) Brian M. Kevany et al.   PHYSIOLOGY

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina

(2008) Yoshikazu Imanishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal myopathies: An excessive build-up in autophagosomes is too much to handle

(2008) May Christine Malicdan et al.   NEUROMUSCULAR DISORDERS

Regulation of the V-ATPase along the Endocytic Pathway Occurs through Reversible Subunit Association and Membrane Localization

(2008) Céline Lafourcade et al.   PLoS One

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

(2007) John et al.   Frontiers in Bioscience-Landmark

βA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development

(2007) Debasish Sinha et al.   MOLECULAR AND CELLULAR NEUROSCIENCE