Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing

Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia

(2018) Maya Barben et al.   Molecular Neurodegeneration

Epigenetic Control of Autophagy: Nuclear Events Gain More Attention

(2017) Sung Hee Baek et al.   MOLECULAR CELL

Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency

(2017) Megan Mayerle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Mechanisms in Initiating and Terminating Autophagy

(2017) Manuela Antonioli et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mice deficient in the Vici syndrome gene Epg5 exhibit features of retinitis pigmentosa

(2016) Guangyan Miao et al.   Autophagy

Fanconi Anemia Proteins Function in Mitophagy and Immunity

(2016) Rhea Sumpter et al.   CELL

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

Structure and function of the ULK1 complex in autophagy

(2016) Mary G Lin et al.   CURRENT OPINION IN CELL BIOLOGY

Peroxisomal protein PEX13 functions in selective autophagy

(2016) Ming Y Lee et al.   EMBO REPORTS

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Autophagy in the eye: Development, degeneration, and aging

(2016) Patricia Boya et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

(2016) Toshihide Kurihara et al.   eLife

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

BECN1s, a short splice variant of BECN1, functions in mitophagy

(2015) Bing Cheng et al.   Autophagy

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

(2015) Jie Li et al.   Autophagy

BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Ubiquitin-associated Domain-containing Ubiquitin Regulatory X (UBX) Protein UBXN1 Is a Negative Regulator of Nuclear Factor κB (NF-κB) Signaling

(2015) Yu-Bo Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes

(2015) Gabrielle Wheway et al.   NATURE CELL BIOLOGY

RNA mis-splicing in disease

(2015) Marina M. Scotti et al.   NATURE REVIEWS GENETICS

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

(2015) A Sveen et al.   ONCOGENE

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa

(2014) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

(2014) R. M. Ivatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe

(2014) R Mu et al.   Cell Death & Disease

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy

(2013) Valerie Lefebvre et al.   Autophagy

Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins

(2013) Chao Liu et al.   BMC CELL BIOLOGY

Alternative splicing and retinal degeneration

(2013) M M Liu et al.   CLINICAL GENETICS

Chlorogenic Acid and Coffee Prevent Hypoxia-Induced Retinal Degeneration

(2013) Holim Jang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

(2013) Samuel A. Hasson et al.   NATURE

Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway

(2012) Katherine H Fisher et al.   BMC GENOMICS

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

(2012) E. Itakura et al.   JOURNAL OF CELL SCIENCE

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

(2012) Yueguang Rong et al.   NATURE CELL BIOLOGY

A Missense Mutation in PRPF6 Causes Impairment of pre-mRNA Splicing and Autosomal-Dominant Retinitis Pigmentosa

(2011) Goranka Tanackovic et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

Temporal and Tissue Specific Regulation of RP-Associated Splicing Factor Genes PRPF3, PRPF31 and PRPC8—Implications in the Pathogenesis of RP

(2011) Huibi Cao et al.   PLoS One

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait

(2010) Alan F. Wright et al.   NATURE REVIEWS GENETICS

Regulation of human metabolism by hypoxia-inducible factor

(2010) Federico Formenti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autosomal-Dominant Retinitis Pigmentosa Caused by a Mutation in SNRNP200, a Gene Required for Unwinding of U4/U6 snRNAs

(2009) Chen Zhao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hypoxia and Neurodegeneration

(2009) Chris Peers et al.   Annals of the New York Academy of Sciences

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

(2009) Sónia C. Correia et al.   JOURNAL OF NEUROCHEMISTRY

Retinal Artery OcclusionAssociated Systemic and Ophthalmic Abnormalities

(2009) Sohan Singh Hayreh et al.   OPHTHALMOLOGY

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

(2009) B. Chen et al.   SCIENCE

Activation of autophagy in retinal ganglion cells

(2008) Seok Hwan Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE