Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Host-derived mannose glycans trigger a pathogenic γδ T cell/IL-17a axis in autoimmunity

(2023) Inês Alves et al.   Science Translational Medicine

A De Novo Cause of PGM3 Deficiency Treated with Hematopoietic Stem Cell Transplantation

(2022) Andrew Winslow et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Altered IgG glycosylation at COVID‐19 diagnosis predicts disease severity

(2022) Manuel M. Vicente et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glycans as shapers of tumour microenvironment: A sweet driver of T‐cell‐mediated anti‐tumour immune response

(2022) Ângela Fernandes et al.   IMMUNOLOGY

From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis

(2022) Hans Ulrich Scherer et al.   Nature Reviews Rheumatology

Coordinated changes in glycosylation regulate the germinal center through CD22

(2022) Jhon R. Enterina et al.   Cell Reports

Divergent Golgi trafficking limits B cell‐mediated IgG sialylation

(2022) Leandre M. Glendenning et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sialic acids on B cells are crucial for their survival and provide protection against apoptosis

(2022) Alexandra T. Linder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

(2022) Guy Werlen et al.   Nature Communications

A Special Virtual Issue Celebrating the 2022 Nobel Prize in Chemistry for the Development of Click Chemistry and Bioorthogonal Chemistry

(2022) Carolyn Bertozzi   ACS Central Science

SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells

(2021) Conor J. Kearney et al.   Science Advances

SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis

(2021) Inês Alves et al.   JOURNAL OF IMMUNOLOGY

Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis

(2020) Márcia S. Pereira et al.   Clinical and Translational Gastroenterology

N-Glycan Branching Is Required for Development of Mature B Cells

(2020) Christie-Lynn Mortales et al.   JOURNAL OF IMMUNOLOGY

Cosmc controls B cell homing

(2020) Junwei Zeng et al.   Nature Communications

The sialyltransferase ST3Gal-IV guides murine T-cell progenitors to the thymus

(2020) Selina Sitte et al.   Blood Advances

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

(2020) Mads Delbo Larsen et al.   SCIENCE

N ‐linked glycans in the variable domain of ACPA ‐IgG predict the development of rheumatoid arthritis

(2019) Lise Hafkenscheid et al.   Arthritis & Rheumatology

Ablation of core fucosylation attenuates the signal transduction via T cell receptor to suppress the T cell development

(2019) Wei Liang et al.   MOLECULAR IMMUNOLOGY

N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development

(2019) Rochelle D. Vergroesen et al.   Frontiers in Immunology

Metabolic control of T cell immune response through glycans in inflammatory bowel disease

(2018) Ana M. Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of galectin-3 modifies differentially Notch ligands in bone marrow and spleen stromal cells interfering with B cell differentiation

(2018) Felipe Leite de Oliveira et al.   Scientific Reports

Lack of Galectin-3 Disrupts Thymus Homeostasis in Association to Increase of Local and Systemic Glucocorticoid Levels and Steroidogenic Machinery

(2018) Ednéa Oliveira-de-Abreu et al.   Frontiers in Endocrinology

A (glyco)biomarker that predicts failure to standard therapy in Ulcerative Colitis patients

(2018) Márcia S Pereira et al.   Journal of Crohns & Colitis

Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans

(2018) N. Giovannone et al.   Nature Communications

Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells

(2018) Eric E. Irons et al.   Frontiers in Immunology

Multiple Roles of Glycans in Hematological Malignancies

(2018) Xingchen Pang et al.   Frontiers in Oncology

Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans

(2018) Nicholas Giovannone et al.   Frontiers in Immunology

Glycans as Key Checkpoints of T Cell Activity and Function

(2018) Márcia S. Pereira et al.   Frontiers in Immunology

O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

(2017) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanisms of T Cell Selection in the Thymus

(2017) Hiroyuki Takaba et al.   TRENDS IN IMMUNOLOGY

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans

(2016) Lise Hafkenscheid et al.   MOLECULAR & CELLULAR PROTEOMICS

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

B-cell–independent sialylation of IgG

(2016) Mark B. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis

(2016) Haik Mkhikian et al.   eLife

Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man

(2015) Matthew S. Macauley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development

(2015) Yinghui Song et al.   JOURNAL OF IMMUNOLOGY

Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions

(2015) Jeremy Bonzi et al.   Nature Communications

PGM3 Mutations Cause a Congenital Disorder of Glycosylation with Severe Immunodeficiency and Skeletal Dysplasia

(2014) Asbjørg Stray-Pedersen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment

(2014) Yu Zhang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Overview of the Intrathymic Intricacies of T Cell Development

(2014) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca2+ signaling

(2014) Raymond W Zhou et al.   NATURE IMMUNOLOGY

Three Decades of Research on O-GlcNAcylation – A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism

(2014) Gerald W. Hart   Frontiers in Endocrinology

CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling

(2013) J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Functional P-Selectin Glycoprotein Ligand 1 on Hematopoietic Progenitors Is Developmentally Regulated

(2012) D. A. Sultana et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions

(2011) D. Yao et al.   BLOOD

Core Fucosylation of μ Heavy Chains Regulates Assembly and Intracellular Signaling of Precursor B Cell Receptors

(2011) Wenzhe Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Congenital disorders of glycosylation

(2010) Jaak Jaeken   Annals of the New York Academy of Sciences

N-linked glycosylation selectively regulates autonomous precursor BCR function

(2010) Rudolf Übelhart et al.   NATURE IMMUNOLOGY

Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions

(2009) M. Espeli et al.   BLOOD

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

Polysialic acid governs T-cell development by regulating progenitor access to the thymus

(2009) P. M. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of acute lymphopblastic leukemia cells with C-type lectins DC-SIGN and L-SIGN

(2008) Karlijn Gijzen et al.   EXPERIMENTAL HEMATOLOGY

The earliest thymic progenitors for T cells possess myeloid lineage potential

(2008) J. Jeremiah Bell et al.   NATURE