Article
Chemistry, Multidisciplinary
Razie Amraei, Wenqing Yin, Marc A. Napoleon, Ellen L. Suder, Jacob Berrigan, Qing Zhao, Judith Olejnik, Kevin Brown Chandler, Chaoshuang Xia, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, Aaron G. Schmidt, Suryaram Gummuluru, Elke Muehlberger, Vipul Chitalia, Catherine E. Costello, Nader Rahimi
Summary: The study identified CD209L and CD209 as receptors for SARS-CoV-2 entry into human cells. CD209L is prominently expressed in lung and kidney tissues and interacts with ACE2, potentially playing a role in SARS-CoV-2 infection. This finding may have implications for antiviral drug development in tissues where ACE2 expression is low or absent.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Pengwei Zhao, Ling-Dong Xu, Yating Zhang, Hongwei Cao, Ruiai Chen, Bin Wang, Yao-Wei Huang
Summary: The study found that human C-type lectin DC-SIGN/L-SIGN and its porcine homolog pDC-SIGN can promote the cellular entry and propagation of porcine epidemic diarrhea virus (PEDV), providing a new theoretical basis for understanding the infection mechanism of PEDV.
MICROBIAL PATHOGENESIS
(2021)
Review
Biology
Nader Rahimi
Summary: The interaction between the S protein of SARS-CoV-2 and CD209 family proteins plays a crucial role in the virus's transmission and infection process, potentially leading to dysregulation of the host immune response and affecting various organs, including the cardiovascular system. Understanding the mechanisms behind this interaction could provide insights for therapies and vaccine development.
Article
Biochemistry & Molecular Biology
Marije E. E. Kuipers, D. Linh Nguyen, Angela van Diepen, Lynn Mes, Erik Bos, Roman I. I. Koning, Esther N. M. Nolte-'t Hoen, Hermelijn H. H. Smits, Cornelis H. H. Hokke
Summary: Adult schistosome worms release extracellular vesicles (EVs) with a specific glycosylation profile that interacts with the host through different receptors compared to the EVs released by the schistosomula stage, indicating their distinct roles in the parasite's life-stage specific interactions with the host.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Chemistry, Medicinal
Jonathan Cramer, Butrint Aliu, Xiaohua Jiang, Timothy Sharpe, Lijuan Pang, Adrian Hadorn, Said Rabbani, Beat Ernst
Summary: Research has shown that mannose-functionalized poly-L-lysine glycoconjugates efficiently inhibit viral attachment and prevent virus binding to DC-SIGN receptors. After treatment, these polymers can lead to prolonged receptor internalization and inhibition of virus binding for up to 6 hours.
Article
Chemistry, Multidisciplinary
Irene Herrera-Gonzalez, Manuel Gonzalez-Cuesta, Michel Thepaut, Eugenie Laigre, David Goyard, Javier Rojo, Jose M. Garcia Fernandez, Franck Fieschi, Olivier Renaudet, Pedro M. Nieto, Carmen Ortiz Mellet
Summary: The carbohydrate chemical mimicry of sp2-iminosugars enables the synthesis of high-mannose-type oligosaccharide analogs whose solution and lectin bound conformations match those of the natural partners. The ability to finely modulate the binding affinity and selectivity towards specific lectins by incorporating the OMJ sp2-iminosugar caps offers potential applications in various fields.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Microbiology
Lillian F. Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M. Young, Renato L. Santos, Manuela Raffatellu, Brian A. Cobb, Hirotaka Hiyoshi, Andreas J. Baeumler
Summary: Salmonella enterica subspecies enterica serovar Typhi is the causative agent of typhoid fever, and the recent emergence of antibiotic-resistant S. Typhi strains highlights the importance of vaccination. The study identified the human C-type lectin receptor DC-SIGN as the receptor for the Vi capsular polysaccharide, which contributes to the pathogenesis of typhoid fever.
Article
Biochemistry & Molecular Biology
Giacomo Biagiotti, Edvin Puric, Ana Kriselj, Matjaz Weiss, Janez Mravljak, Cristina Gellini, Luigi Lay, Fabrizio Chiodo, Marko Anderluh, Stefano Cicchi, Barbara Richichi, Iztok Urbancic
Summary: The synthesis of glyco-BODIPYs 1 and 2 based on efficient chemical reactions allows for efficient targeting of lectins. Glyco-BODIPY 1, with stable C-mannose residues, is effective in targeting DC-SIGN receptors in immune cells. Super-resolution STED microscopy demonstrates that glyco-BODIPY 1 can be used for tracking lectin-mediated cell internalization in diverse biological settings.
BIOORGANIC CHEMISTRY
(2021)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Microbiology
Lieve E. H. van der Donk, Marta Bermejo-Jambrina, John L. van Hamme, Mette M. W. Volkers, Ad C. van Nuenen, Neeltje A. Kootstra, Teunis B. H. Geijtenbeek
Summary: This study found that SARS-CoV-2 can directly suppress immune responses to bacteria in human dendritic cells, possibly by interacting with DC-SIGN and modulating the Raf-1 pathway. This may explain the higher mortality rates observed in patients with COVID-19 and bacterial superinfections.
Review
Immunology
Charlotte Castenmiller, Brigitte-Carole Keumatio-Doungtsop, Ronald van Ree, Esther C. de Jong, Yvette van Kooyk
Summary: Dendritic cells play key roles in regulating immune responses by inducing either inflammatory or tolerogenic reactions. Research interest is growing in defining tolerance-inducing receptors on DCs for developing new immunotherapeutic strategies. Targeting strategies such as antigen-carbohydrate conjugates and antibody-antigen fusion proteins aim to induce a tolerogenic DC phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Lei Guo, Yan Liang, Heng Li, Huiwen Zheng, Zening Yang, Yanli Chen, Xin Zhao, Jing Li, Binxiang Li, Haijing Shi, Ming Sun, Longding Liu
Summary: Glycosylation of the SARS-CoV-2 spike glycoprotein is crucial for viral entry and immune evasion, with different glycan patterns affecting binding affinities to C-type lectin receptors. Although C-type lectin receptors do not support productive viral infection, they play a significant role in viral trans and cis-infection, especially with virions containing a high-mannose structure at specific glycan sites. This highlights the importance of viral epigenetic glycosylation in authentic viral infection and the co-receptor role of DC&L-SIGN in SARS-CoV-2 infection and prevention.
Article
Chemistry, Multidisciplinary
Robert Wawrzinek, Eike-Christian Wamhoff, Jonathan Lefebre, Mareike Rentzsch, Gunnar Bachem, Gary Domeniconi, Jessica Schulze, Felix F. Fuchsberger, Hengxi Zhang, Carlos Modenutti, Lennart Schnirch, Marcelo A. Marti, Oliver Schwardt, Maria Braeutigam, Monica Guberman, Dirk Hauck, Peter H. Seeberger, Oliver Seitz, Alexander Titz, Beat Ernst, Christoph Rademacher
Summary: Dendritic cells play a crucial role in coordinating immune responses, with new research showing potential for improved targeting of specific dendritic cell subtypes. This discovery has important implications for immunotherapy and anti-infectives.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Ryosuke Wakabayashi, Yasunao Hattori, Shigekuni Hosogi, Yuki Toda, Kazuyuki Takata, Eishi Ashihara
Summary: Compound 31 was identified as an inhibitor of the Wnt/beta-catenin pathway, showing potential as a novel anti-AML agent by suppressing TCF activity, reducing AML cell proliferation, inducing apoptosis, and synergistically inhibiting cell growth when combined with idarubicin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xia Yao, Shuai Gao, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yan
Summary: The study reveals the molecular basis for the physical and pharmacodynamic interaction of sofosbuvir and amiodarone on the scaffold of Cav channels.
Article
Oncology
Steve Boudewijns, Martine Bloemendal, Nienke de Haas, Harm Westdorp, Kalijn F. Bol, Gerty Schreibelt, Erik H. J. G. Aarntzen, W. Joost Lesterhuis, Mark A. J. Gorris, Alexandra Croockewit, Lieke L. van der Woude, Michelle M. van Rossum, Marieke Welzen, Anna de Goede, Stanleyson Hato, Winette T. A. van der Graaf, Cornelis J. A. Punt, Rutger H. T. Koornstra, Winald R. Gerritsen, Carl G. Figdor, I. Jolanda M. de Vries
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Cell Biology
Antoine A. Khalil, Olga Ilina, Angela Vasaturo, Jan-Hendrik Venhuizen, Manon Vullings, Victor Venhuizen, Ab Bilos, Carl G. Figdor, Paul N. Span, Peter Friedl
JOURNAL OF CELL BIOLOGY
(2020)
Article
Oncology
Harm Westdorp, Jeroen H. A. Creemers, Inge M. van Oort, Niven Mehra, Simone M. Hins-de Bree, Carl G. Figdor, J. Alfred Witjes, Gerty Schreibelt, I. Jolanda M. de Vries, Winald R. Gerritsen, Petronella B. Ottevanger
FRONTIERS IN ONCOLOGY
(2020)
Article
Hematology
Giorgia Chiodin, Joel D. Allen, Dean J. Bryant, Philip Rock, Enrica A. Martino, Beatriz Valle-Argos, Patrick J. Duriez, Yasunori Watanabe, Isla Henderson, James S. Blachly, Katy J. McCann, Jonathan C. Strefford, Graham Packham, Teunis B. H. Geijtenbeek, Carl G. Figdor, George W. Wright, Louis M. Staudt, Richard Burack, Thomas A. Bowden, Max Crispin, Freda K. Stevenson, Francesco Forconi
Summary: The glycosylation of the Ig variable region is a rare feature associated with follicular lymphoma, and some DLBCLs acquire N-glycosylation sites selectively in the CDRs of the antigen-binding sites, particularly in the EZB subtype; this contrasts with the activated B-cell-like DLBCL Ig. The acquisition of these sites is associated with mutations of epigenetic regulators and BCL2 translocations, and the oligomannosylated tumor Ig can be a potential therapeutic target against DC-SIGN-expressing M2-polarized macrophages.
Article
Multidisciplinary Sciences
Bettina Weigelin, Annemieke Th den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor, Peter Friedl
Summary: The study demonstrates that sublethal interactions from multiple CTL can accumulate over time and achieve tumor cell killing by additive cytotoxicity. Statistical modeling reveals that delivering three serial hits within decay intervals below 50 minutes can distinguish between tumor cell death or survival after recovery.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Jeroen Slaats, Cindy E. Dieteren, Esther Wagena, Louis Wolf, Tonke K. Raaijmakers, Jeroen A. van der Laak, Carl G. Figdor, Bettina Weigelin, Peter Friedl
Summary: The study introduced a three-dimensional interface coculture model to investigate the mechanisms of CTL cytotoxicity against tumor cells, and identified the crucial role of CRAC channel activity in modulating CTL effector function.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Massis Krekorian, Kimberley R. G. Cortenbach, Milou Boswinkel, Annemarie Kip, Gerben M. Franssen, Andor Veltien, Tom W. J. Scheenen, Rene Raave, Nicolaas Koen van Riessen, Mangala Srinivas, Ingrid Jolanda M. de Vries, Carl G. Figdor, Erik H. J. G. Aarntzen, Sandra Heskamp
Summary: This study successfully demonstrated in vivo tracking of a small number of immune cells using zirconium-89-labeled poly(lactic-co-glycolic acid) nanoparticles, showing potential applications in various disease models.
Article
Oncology
Mark A. J. Gorris, Lieke L. van der Woude, Leonie Kroeze, Kalijn Bol, Kiek Verrijp, Avital L. Amir, Jelena Meek, Johannes Textor, Carl G. Figdor, I. Jolanda M. de Vries
Summary: This study found that TIL density and composition were remarkably similar between different metastatic melanoma lesions within an individual patient, as well as HLA-ABC status. High TMB directly correlated with response to ipilimumab, while lymphocyte density or composition did not show a similar correlation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Lieke L. van der Woude, Mark A. J. Gorris, Inge M. N. Wortel, Jeroen H. A. Creemers, Kiek Verrijp, Kim Monkhorst, Katrien Grunberg, Michel M. van den Heuvel, Johannes Textor, Carl G. Figdor, Berber Piet, Willemijn S. M. E. Theelen, I. Jolanda M. de Vries
Summary: This study found that lymphocyte infiltration in the tumor microenvironment is associated with response to therapy in NSCLC patients, regardless of the specific lymphocyte subset. Additionally, the combination of anti-PD-1 and SBRT induced a higher infiltration of cytotoxic T cells compared to anti-PD-1 monotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Jeroen H. A. Creemers, Ankur Ankan, Kit C. B. Roes, Gijs Schroeder, Niven Mehra, Carl G. Figdor, I. Jolanda M. de Vries, Johannes Textor
Summary: Late-stage cancer immunotherapy trials often result in unique survival curve shapes, and it is crucial to anticipate and adjust the trial design accordingly. This study used simulated trials based on three mathematical models to investigate the survival curve shapes associated with immunotherapies. By simulating different scenarios, the authors demonstrated how trial design choices can be scrutinized and potential pitfalls can be identified. They also provided web-based implementations of their simulation models to facilitate their use by biomedical researchers, doctors, and trialists.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Marjolein Schluck, Loek J. Eggermont, Jorieke Weiden, Carlijn Popelier, Lea Weiss, Bas Pilzecker, Sigrid Kolder, Anne Heinemans, Carla Rodriguez Mogeda, Martijn Verdoes, Carl G. Figdor, Roel Hammink
Summary: In this study, nanosized aAPCs immunofilaments were used to investigate the role of co-stimulatory molecules in T-cell signaling. The findings highlight the importance of CD28 and CD2 signaling in T-cell function and could be used for future design of cancer immunotherapies.
ADVANCED THERAPEUTICS
(2022)
Article
Oncology
Jeroen H. A. Creemers, W. Joost Lesterhuis, Niven Mehra, Winald R. Gerritsen, Carl G. Figdor, I. Jolanda M. de Vries, Johannes Textor
Summary: This study used computational modeling to reveal a strong nonlinear relationship between immune therapy response and patient survival with immunological and tumor-related parameters. It identified a tipping point where patients close to it may benefit from immune therapy while those far from it may not. This finding suggests the importance of combining both types of biomarkers for better treatment selection in cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Meeting Abstract
Immunology
Georgina Florez Grau, Mark A. J. Gorris, Johanna Bodder, Jorge Cuenca Escalona, Camille Le Gall, Jasper J. P. Van Beek, Kevin Bos, Daphne Roelofs, Gerty Schreibelt, Carl G. Figdor, I. Jolanda M. De Vries
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Laia Querol Cano, Oya Tagit, Yusuf Dolen, Anne van Duffelen, Shannon Dieltjes, Sonja Buschow, Toshiro Niki, Mitsuomi Hirashima, Ben Joosten, Koen van den Dries, Alessandra Cambi, Carl G. Figdor, Annemiek B. van Spriel
Review
Medicine, Research & Experimental
Massis Krekorian, Gilbert O. Fruhwirth, Mangala Srinivas, Carl G. Figdor, Sandra Heskamp, Timothy H. Witney, Erik H. J. G. Aarntzen