Mitochondrial regulation in stem cells

The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging

(2023) Chih-Ling Wang et al.   Cell Metabolism

The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy

(2023) Tomoyuki Fukuda et al.   MOLECULAR CELL

Spatial mapping of mitochondrial networks and bioenergetics in lung cancer

(2023) Mingqi Han et al.   NATURE

Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation

(2023) Zhiya Deng et al.   Autophagy

Metabolic determination of cell fate through selective inheritance of mitochondria

(2022) Julia Döhla et al.   NATURE CELL BIOLOGY

ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration

(2022) Terumasa Umemoto et al.   EMBO JOURNAL

Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex

(2022) Xiaoxiang Dong et al.   NATURE NEUROSCIENCE

Ageing and rejuvenation of tissue stem cells and their niches

(2022) Anne Brunet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells

(2022) Nicole Baker et al.   Cell Stem Cell

Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

(2022) Xiaotong Hong et al.   Cell Stem Cell

Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging

(2022) Wesley Wong et al.   Molecular Metabolism

The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease

(2022) Rika Ohkubo et al.   Cell Reports

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

(2021) Koichi Murakami et al.   Cell Reports

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

(2021) Marlies P. Rossmann et al.   SCIENCE

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

(2021) Xuan Sun et al.   Nature Communications

The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals

(2021) Xiaoqiang Sheng et al.   EBioMedicine

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

(2020) Ashwini Hinge et al.   Cell Stem Cell

SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice

(2020) Guo Li et al.   EMBO JOURNAL

Folding the Mitochondrial UPR into the Integrated Stress Response

(2020) Nadine S. Anderson et al.   TRENDS IN CELL BIOLOGY

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

(2020) Shijia Bi et al.   Protein & Cell

A Cellular Mechanism to Detect and Alleviate Reductive Stress

(2020) Andrew G. Manford et al.   CELL

Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

(2020) Els Mansell et al.   Cell Stem Cell

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

(2020) Ryohei Iwata et al.   SCIENCE

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

(2019) Hanzhi Luo et al.   Cell Reports

TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation

(2019) Wenjuan Zhou et al.   Cell Death & Disease

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

(2019) Nicola Vannini et al.   Cell Stem Cell

NAD + supplementation rejuvenates aged gut adult stem cells

(2019) Masaki Igarashi et al.   AGING CELL

Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis

(2019) Rafael Sênos Demarco et al.   NATURE CELL BIOLOGY

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence

(2018) Mary Mohrin et al.   AGING CELL

Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function

(2018) Darren Q. Tan et al.   ANTIOXIDANTS & REDOX SIGNALING

Ca2+–mitochondria axis drives cell division in hematopoietic stem cells

(2018) Terumasa Umemoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

(2018) Karin Golan et al.   Cell Stem Cell

Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin

(2018) Meng-Ju Wu et al.   Cell Metabolism

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells

(2017) Shohei Murakami et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

SIRT3 in Neural Stem Cells Attenuates Microglia Activation-Induced Oxidative Stress Injury Through Mitochondrial Pathway

(2017) De-Qi Jiang et al.   Frontiers in Cellular Neuroscience

ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation

(2017) Suman Das et al.   Cell Reports

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

The mitochondrial metabolic checkpoint and aging of hematopoietic stem cells

(2016) Mary Mohrin et al.   CURRENT OPINION IN HEMATOLOGY

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

(2016) Larry L. Luchsinger et al.   NATURE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

(2016) K. Ito et al.   SCIENCE

Mitochondrial function controls intestinal epithelial stemness and proliferation

(2016) Emanuel Berger et al.   Nature Communications

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

(2013) Wen-Mei Yu et al.   Cell Stem Cell

Nrf2 regulates haematopoietic stem cell function

(2013) Jennifer J. Tsai et al.   NATURE CELL BIOLOGY

Molecular regulation of stem cell quiescence

(2013) Tom H. Cheung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo

(2013) Nathaniel W. Hartman et al.   Cell Reports

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE