ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex

(2021) Jalila Chagraoui et al.   Cell Stem Cell

JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality

(2021) Tata Nageswara Rao et al.   BLOOD

Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions

(2021) Takao Sudo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH

(2020) Mingjun Tan et al.   CELL DEATH AND DIFFERENTIATION

Hematopoietic Stem Cell Metabolism during Development and Aging

(2020) Ayako Nakamura-Ishizu et al.   DEVELOPMENTAL CELL

Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

(2020) Els Mansell et al.   Cell Stem Cell

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses

(2020) Ryan Houston et al.   PLOS BIOLOGY

Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation

(2020) Maiko Sezaki et al.   Frontiers in Immunology

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

(2019) Nicola Vannini et al.   Cell Stem Cell

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

(2019) Nicolas Severe et al.   Cell Stem Cell

Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury

(2019) Qi Chen et al.   Cell Stem Cell

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

Ca2+–mitochondria axis drives cell division in hematopoietic stem cells

(2018) Terumasa Umemoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

(2018) Amir Giladi et al.   NATURE CELL BIOLOGY

Single-cell full-length total RNA sequencing uncovers dynamics of recursive splicing and enhancer RNAs

(2018) Tetsutaro Hayashi et al.   Nature Communications

Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation

(2018) Ayako Nakamura-Ishizu et al.   Cell Reports

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells

(2017) Mina N.F. Morcos et al.   Stem Cell Reports

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

(2016) Nicola Vannini et al.   Nature Communications

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

(2015) Nicola K. Wilson et al.   Cell Stem Cell

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

(2015) Xiongwei Cai et al.   Cell Stem Cell

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

(2015) Shiri Gur-Cohen et al.   NATURE MEDICINE

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis

(2014) Weisheng Wu et al.   GENOME RESEARCH

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin state dynamics during blood formation

(2014) D. Lara-Astiaso et al.   SCIENCE

Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects

(2014) Chelsia Qiuxia Wang et al.   Cell Reports

The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?

(2014) Mohamed Amin Choukrallah et al.   Frontiers in Immunology

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

(2011) Xiongwei Cai et al.   PLoS One

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Runx2 induces acute myeloid leukemia in cooperation with Cbf -SMMHC in mice

(2009) Y.-H. Kuo et al.   BLOOD

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE