Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis

Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis

(2023) Ruzanna Shkhyan et al.   Science Translational Medicine

Matrikines as mediators of tissue remodelling

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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

(2022) Pakorn Kanchanawong et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nebulosa recovers single-cell gene expression signals by kernel density estimation

(2021) Jose Alquicira-Hernandez et al.   BIOINFORMATICS

Shear and Integrin Outside-In Signaling Activates NADPH-Oxidase 2 to Promote Platelet Activation

(2021) Zheng Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structural insights into integrin α5β1 opening by fibronectin ligand

(2021) Stephanie Schumacher et al.   Science Advances

Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin

(2021) Tenghui Tao et al.   Frontiers in Cell and Developmental Biology

14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis

(2021) Wenyu Fu et al.   ANNALS OF THE RHEUMATIC DISEASES

Early-stage symptomatic osteoarthritis of the knee — time for action

(2021) Armaghan Mahmoudian et al.   Nature Reviews Rheumatology

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis

(2021) Tom Hodgkinson et al.   Nature Reviews Rheumatology

Tyrosine kinases regulate chondrocyte hypertrophy: promising drug targets for Osteoarthritis

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Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

(2021) Tal M. Dankovich et al.   Nature Communications

Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation

(2020) Jessica B. Behring et al.   Science Signaling

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

(2020) Nestor N. Jimenez-Vargas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

(2018) Quanbo Ji et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis

(2018) K.M. Fisch et al.   OSTEOARTHRITIS AND CARTILAGE

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

(2018) Dhiren F. Patel et al.   Science Translational Medicine

Integrin trafficking in cells and tissues

(2018) Paulina Moreno-Layseca et al.   NATURE CELL BIOLOGY

Direct cysteine sulfenylation drives activation of the Src kinase

(2018) David E. Heppner et al.   Nature Communications

The extracellular matrix in myocardial injury, repair, and remodeling

(2017) Nikolaos G. Frangogiannis   JOURNAL OF CLINICAL INVESTIGATION

Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs

(2017) Sylvie Ricard-Blum et al.   MATRIX BIOLOGY

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

(2017) Dane D. Jensen et al.   Science Translational Medicine

Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2

(2017) Ryouhei Tsutsumi et al.   Nature Communications

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase

(2016) Nadine Müller-Calleja et al.   ANNALS OF THE RHEUMATIC DISEASES

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly

(2016) Guilherme P. F. Nader et al.   NATURE CELL BIOLOGY

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Enhanced phagocytic capacity endows chondrogenic progenitor cells with a novel scavenger function within injured cartilage

(2016) C. Zhou et al.   OSTEOARTHRITIS AND CARTILAGE

Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints

(2016) Maria Elena Candela et al.   PLoS One

Proteolytic fragments of fibronectin function as matrikines driving the chemotactic affinity of prostate cancer cells to human bone marrow mesenchymal stromal cells via the α5β1 integrin

(2016) Raghav Joshi et al.   Cell Adhesion & Migration

Persistent cell migration and adhesion rely on retrograde transport of β1 integrin

(2015) Massiullah Shafaq-Zadah et al.   NATURE CELL BIOLOGY

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings

(2015) Thomas Pap et al.   Nature Reviews Rheumatology

Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments

(2015) Scott T. Wood et al.   Arthritis & Rheumatology

The matrikine N- -PGP couples extracellular matrix fragmentation to endothelial permeability

(2015) C. S. Hahn et al.   Science Advances

The Basic Biology of Redoxosomes in Cytokine-Mediated Signal Transduction and Implications for Disease-Specific Therapies

(2014) Netanya Y. Spencer et al.   BIOCHEMISTRY

Matricryptins and matrikines: biologically active fragments of the extracellular matrix

(2014) Sylvie Ricard-Blum et al.   EXPERIMENTAL DERMATOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Unlike Bone, Cartilage Regeneration Remains Elusive

(2012) D. J. Huey et al.   SCIENCE

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

A Comparative Study of Fibronectin Cleavage by MMP-1, -3, -13, and -14

(2012) Xiaorong Zhang et al.   Cartilage

MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin

(2011) F. Shi et al.   JOURNAL OF CELL SCIENCE

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Does Cellular Hydrogen Peroxide Diffuse or Act Locally?

(2010) Natalia M. Mishina et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signaling Components of Redox Active Endosomes: The Redoxosomes

(2008) Fredrick D. Oakley et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitogen-activated protein kinases as therapeutic targets in osteoarthritis

(2008) Richard F Loeser et al.   CURRENT OPINION IN RHEUMATOLOGY

The cartilage chondrolytic mechanism of fibronectin fragments involves MAP kinases: comparison of three fragments and native fibronectin

(2008) L. Ding et al.   OSTEOARTHRITIS AND CARTILAGE

Endosomal trafficking of Src tyrosine kinase

(2008) Emma Sandilands et al.   TRENDS IN CELL BIOLOGY