Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin

LncRNA MM2P-induced, exosome-mediated transfer of Sox9 from monocyte-derived cells modulates primary chondrocytes

(2020) Jinyu Bai et al.   Cell Death & Disease

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis

(2019) Yvonn Heun et al.   EBioMedicine

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

(2019) Charlène Niogret et al.   Nature Communications

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

(2019) Song Ho Chang et al.   Nature Communications

Anthocyanins and metabolites from purple rice inhibit IL-1β-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-κB and ERK/MAPK pathway

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Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway

(2018) Kai Li et al.   ANNALS OF THE RHEUMATIC DISEASES

Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

(2018) Yujie Deng et al.   Nature Communications

Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients

(2017) Daimin Xiang et al.   HEPATOLOGY

Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis

(2017) Yachuan Zhou et al.   Current Rheumatology Reports

SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion

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Functions of Shp2 in cancer

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Osteoarthritis

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Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

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Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase

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Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

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Osteoarthritis: A disease of the joint as an organ

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Activation of Wnt/β-Catenin Protein Signaling Induces Mitochondria-mediated Apoptosis in Hematopoietic Progenitor Cells

(2012) Ming Ming et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation

(2012) Ilse Timmerman et al.   MOLECULAR BIOLOGY OF THE CELL

Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma

(2011) L-M Sturla et al.   BRITISH JOURNAL OF CANCER

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

β-catenin, cartilage, and osteoarthritis

(2010) Qiuqian Wu et al.   Annals of the New York Academy of Sciences

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

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Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology