Tyrosine kinases regulate chondrocyte hypertrophy: promising drug targets for Osteoarthritis

Effect of Inflammatory Signaling on Human Articular Chondrocyte Hypertrophy: Potential Involvement of Tissue Repair Macrophages

(2021) Mauricio N. Ferrao Blanco et al.   Cartilage

Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial

(2020) Felix Eckstein et al.   ANNALS OF THE RHEUMATIC DISEASES

MiR-375 Mediates Chondrocyte Metabolism and Oxidative Stress in Osteoarthritis Mouse Models through the JAK2/STAT3 Signaling Pathway

(2020) Li-xue Zou et al.   CELLS TISSUES ORGANS

ROR2 knockdown suppresses breast cancer growth through PI3K/ATK signaling

(2020) Muhong Guo et al.   Aging-US

Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis

(2020) Ching-Heng Chou et al.   Scientific Reports

ROR2 blockade as a therapy for osteoarthritis

(2020) Anne-Sophie Thorup et al.   Science Translational Medicine

Role of NGF-TrkA signaling in calcification of articular chondrocytes

(2019) Yangzi Jiang et al.   FASEB JOURNAL

Efficacy, Safety, and Tolerability of ONO‐4474, an Orally Available Pan‐Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients With Moderate to Severe Osteoarthritis of the Knee: A Randomized, Placebo‐Controlled, Double‐Blind, Parallel‐Group Comparative Study

(2019) Naoki Ishiguro et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Efficacy and safety of intra-articular injection of tropomyosin receptor kinase A inhibitor in painful knee osteoarthritis: a randomized, double-blind and placebo-controlled study

(2019) E. Krupka et al.   OSTEOARTHRITIS AND CARTILAGE

Tropomyosin-related Kinase A (TrkA) Inhibition for the Treatment of Painful Knee Osteoarthritis: Results From a Randomized Controlled Phase 2a Trial

(2019) Fiona Watt et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting Discoidin Domain Receptor 2 for the Development of Disease-Modifying Osteoarthritis Drugs

(2019) Li Xiao et al.   Cartilage

FDA- and EMA-Approved Tyrosine Kinase Inhibitors in Advanced EGFR-Mutated Non-Small Cell Lung Cancer: Safety, Tolerability, Plasma Concentration Monitoring, and Management

(2019) Isabelle Solassol et al.   Biomolecules

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

(2019) Rashmi K. Murthy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

(2018) Quanbo Ji et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy of tivozanib treatment after sorafenib in patients with advanced renal cell carcinoma: crossover of a phase 3 study

(2018) Ana M. Molina et al.   EUROPEAN JOURNAL OF CANCER

Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo

(2018) Cecilie F. Kjelgaard-Petersen et al.   BIOCHEMICAL PHARMACOLOGY

mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis

(2017) H. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Oral Tyrosine Kinase Inhibitor for Neovascular Age-Related Macular Degeneration

(2017) Timothy L. Jackson et al.   JAMA Ophthalmology

A phase I study of MK-0646, a humanized monoclonal antibody against the insulin-like growth factor receptor type 1 (IGF1R) in advanced solid tumor patients in a q2 wk schedule

(2017) M. Hidalgo et al.   JOURNAL OF CLINICAL ONCOLOGY

Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway

(2016) Zhen Cao et al.   BMB Reports

Inhibition of vascular endothelial growth factor with shRNA in chondrocytes ameliorates osteoarthritis

(2016) Xufang Zhang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3

(2016) Hye-Young Seo et al.   KIDNEY INTERNATIONAL

Fibroblast Growth Factor 23 drives MMP13 expression in human osteoarthritic chondrocytes in a Klotho-independent manner

(2016) A. Bianchi et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of ROR1 has prognostic significance in triple negative breast cancer

(2016) Hui-Ping Chien et al.   VIRCHOWS ARCHIV

Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice

(2016) Junzhou Tang et al.   Arthritis & Rheumatology

Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior

(2016) Clare Driscoll et al.   Arthritis & Rheumatology

A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis

(2016) Wei Xu et al.   Scientific Reports

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

(2015) C. K. Domigan et al.   JOURNAL OF CELL SCIENCE

Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

(2015) Jian Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Injecting vascular endothelial growth factor into the temporomandibular joint induces osteoarthritis in mice

(2015) Pei Shen et al.   Scientific Reports

Non-receptor protein tyrosine kinases signaling pathways in normal and cancer cells

(2014) Elzbieta Gocek et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Experimental chondrocyte hypertrophy is promoted by the activation of discoidin domain receptor 2

(2014) SIHAN ZHANG et al.   Molecular Medicine Reports

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis

(2014) Sunday S. Oladipupo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

(2014) A. J. Brooks et al.   SCIENCE

A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint

(2013) Boris Schminke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes

(2013) Chun-Yin Huang et al.   MEDIATORS OF INFLAMMATION

Anti-Angiogenic Effect of Triptolide in Rheumatoid Arthritis by Targeting Angiogenic Cascade

(2013) Xiangying Kong et al.   PLoS One

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

(2013) Yi-Mi Wu et al.   Cancer Discovery

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

(2012) Tujun Weng et al.   ARTHRITIS AND RHEUMATISM

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Dual IGF-I/II-Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

(2011) J. Gao et al.   CANCER RESEARCH

Collagen I regulates the self-renewal of mouse embryonic stem cells through α2β1 integrin- and DDR1-dependent Bmi-1

(2011) Han Na Suh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expression and function of the insulin receptor in normal and osteoarthritic human chondrocytes: modulation of anabolic gene expression, glucose transport and GLUT-1 content by insulin

(2011) S.C. Rosa et al.   OSTEOARTHRITIS AND CARTILAGE

IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway

(2011) Azadeh Montaseri et al.   PLoS One

Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses

(2011) D. C. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes

(2011) Dongyao Yan et al.   ARTHRITIS RESEARCH & THERAPY

C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express sex hormone and insulin receptors—Useful cells in study of cartilage metabolism

(2010) Horst Claassen et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

(2010) Lin Xu et al.   ARTHRITIS AND RHEUMATISM

Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src

(2010) Katherine Kun Lu et al.   CARDIOVASCULAR PATHOLOGY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of β-catenin signaling

(2010) Lai Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation

(2010) Kuan-Liang Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation

(2010) Yan Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line

(2010) M. Li et al.   Microscopy

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics

(2009) Lindsay O. Kirkland et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

(2009) Weihong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes

(2009) Steeve Kwan Tat et al.   ARTHRITIS RESEARCH & THERAPY

The epidermal growth factor receptor family: Biology driving targeted therapeutics

(2008) M. J. Wieduwilt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Factor XIIIA mobilizes transglutaminase 2 to induce chondrocyte hypertrophic differentiation

(2008) K. A. Johnson et al.   JOURNAL OF CELL SCIENCE