Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo

Mechanisms by Which Inducers of Drug Metabolizing Enzymes Alter Thyroid Hormones in Rats

(2022) Nichole R Vansell   DRUG METABOLISM AND DISPOSITION

IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making

(2022) Xiaoqing Chang et al.   Toxics

Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase

(2022) Jennifer H. Olker et al.   AQUATIC TOXICOLOGY

Histopathological, immunohistochemical, and molecular investigation of atrazine toxic effect on some organs of adult male albino rats with a screening of Acacia nilotica as a protective trial

(2022) Zainab Sabry Othman Ahmed et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Advances in computational methods along the exposure to toxicological response paradigm

(2022) Hisham El-Masri et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

(2021) Jill A. Franzosa et al.   npj Systems Biology and Applications

Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals

(2021) Sally A. Mayasich et al.   TOXICOLOGY IN VITRO

Multi Species Analyses Reveal Testicular T3 Metabolism and Signalling as a Target of Environmental Pesticides

(2021) Valeria Nittoli et al.   Cells

Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay

(2020) Angela R. Buckalew et al.   ARCHIVES OF TOXICOLOGY

Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

(2020) Stephan Couderq et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Induction of immunological, hormonal and histological alterations after sublethal exposure of chlorpyrifos in the freshwater fish, Pseudetroplus maculatus (Bloch, 1795)

(2020) K.P. Raibeemol et al.   FISH & SHELLFISH IMMUNOLOGY

Peripheral T3 signaling is target of pesticides in zebrafish larvae and adult liver

(2020) Marco Colella et al.   JOURNAL OF ENDOCRINOLOGY

Anthropogenic stressors impact fish sensory development and survival via thyroid disruption

(2020) Marc Besson et al.   Nature Communications

Adversity Considerations for Thyroid Follicular Cell Hypertrophy and Hyperplasia in Nonclinical Toxicity Studies: Results From the 6th ESTP International Expert Workshop

(2020) Maike Huisinga et al.   TOXICOLOGIC PATHOLOGY

Crosstalk of cholinergic pathway on thyroid disrupting effects of the insecticide chlorpyrifos in zebrafish (Danio rerio)

(2020) Kun Qiao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism

(2020) Mei Ha et al.   SCIENCE OF THE TOTAL ENVIRONMENT

In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase

(2020) Jennifer H. Olker et al.   TOXICOLOGY IN VITRO

The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency

(2019) Russell S Thomas et al.   TOXICOLOGICAL SCIENCES

Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches

(2019) Pamela D. Noyes et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library

(2019) Katie Paul-Friedman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Nuclear receptors are important targets of environmental disrupting compounds

(2019) Lucia Toporova et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Thyroid-disrupting effects of chlorpyrifos in female Wistar rats

(2019) Joice Karina Otênio et al.   DRUG AND CHEMICAL TOXICOLOGY

The effect of chlorpyrifos on salinity acclimation of juvenile rainbow trout ( Oncorhynchus mykiss )

(2018) Bagher Mojazi Amiri et al.   AQUATIC TOXICOLOGY

High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library

(2018) Jun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Differentiating Pathway-Specific From Nonspecific Effects in High-Throughput Toxicity Data: A Foundation for Prioritizing Adverse Outcome Pathway Development

(2018) Kellie A Fay et al.   TOXICOLOGICAL SCIENCES

The US Federal Tox21 Program: A strategic and operational plan for continued leadership

(2018) Russell Thomas   ALTEX-Alternatives to Animal Experimentation

Acute exposure of zebrafish embryo (Danio rerio) to flutolanil reveals its developmental mechanism of toxicity via disrupting the thyroid system and metabolism

(2018) Miaomiao Teng et al.   ENVIRONMENTAL POLLUTION

Endpoint sensitivity in Amphibian Metamorphosis Assay

(2018) ZhiChao Dang   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Evidence for Cross Species Extrapolation of Mammalian-Based High-Throughput Screening Assay Results

(2018) Carlie A. LaLone et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases

(2018) Jennifer H Olker et al.   TOXICOLOGICAL SCIENCES

Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals

(2018) Helen Prior et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters

(2017) Brett R. Blackwell et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin

(2017) Keishi Yamasaki et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Relevance and reliability of experimental data in human health risk assessment of pesticides

(2017) Johanna Kaltenhäuser et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity

(2017) Michael W Hornung et al.   TOXICOLOGICAL SCIENCES

Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS)

(2017) Daniel R. Hallinger et al.   TOXICOLOGY IN VITRO

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

(2017) Antony J. Williams et al.   Journal of Cheminformatics

Fish larval recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos

(2017) Guillaume Holzer et al.   eLife

tcpl: the ToxCast pipeline for high-throughput screening data

(2016) Dayne L. Filer et al.   BIOINFORMATICS

Development and Validation of a Computational Model for Androgen Receptor Activity

(2016) Nicole C. Kleinstreuer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study

(2016) Katie Paul Friedman et al.   CRITICAL REVIEWS IN TOXICOLOGY

A Nonradioactive DEHAL Assay for Testing Substrates, Inhibitors, and Monitoring Endogenous Activity

(2016) Kostja Renko et al.   ENDOCRINOLOGY

Identifying reference chemicals for thyroid bioactivity screening

(2016) Susanna Wegner et al.   REPRODUCTIVE TOXICOLOGY

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

(2016) Richard Judson et al.   TOXICOLOGICAL SCIENCES

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

(2016) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?

(2015) Frances Xin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

(2015) Kostja Renko et al.   THYROID

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening

(2014) Katie B. Paul et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Should oral gavage be abandoned in toxicity testing of endocrine disruptors?

(2014) Laura N Vandenberg et al.   Environmental Health

ENDOCRINE DISRUPTION: Developmental Picture Window

(2014) Julia R. Barrett   ENVIRONMENTAL HEALTH PERSPECTIVES

Protective role of Nigella sativa oil against reproductive toxicity, hormonal alterations, and oxidative damage induced by chlorpyrifos in male rats

(2014) Rachid Mosbah et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program

(2014)   ALTEX-Alternatives to Animal Experimentation

Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat

(2013) Katie B. Paul et al.   TOXICOLOGY

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

(2013) AlberTinka J. Murk et al.   TOXICOLOGY IN VITRO

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of Iopanoic Acid as Substrate of Type 1 Deiodinase by a Novel Nonradioactive Iodide-Release Assay

(2012) Kostja Renko et al.   ENDOCRINOLOGY

Thyroid effects of endocrine disrupting chemicals

(2011) Malene Boas et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Evaluation of EPA’s Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results

(2011) Christopher J. Borgert et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Application of an Integrated Testing Strategy to the U.S. EPA Endocrine Disruptor Screening Program

(2011) Catherine E. Willett et al.   TOXICOLOGICAL SCIENCES

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

(2011) Thomas B. Knudsen et al.   TOXICOLOGY

Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program

(2010) Matthew T. Martin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Characterization of thyroid hormone transporter expression during tissue-specific metamorphic events in Xenopus tropicalis

(2010) Kristin A. Connors et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Role of UDP-Glucuronosyltransferase (UGT) 2B2 in Metabolism of Triiodothyronine: Effect of Microsomal Enzyme Inducers in Sprague Dawley and UGT2B2-Deficient Fischer 344 Rats

(2010) Terrilyn A. Richardson et al.   TOXICOLOGICAL SCIENCES

Assessing Hormone Receptor Activities of Pyrethroid Insecticides and Their Metabolites in Reporter Gene Assays

(2010) Guizhen Du et al.   TOXICOLOGICAL SCIENCES

Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay

(2010) Jaime Freitas et al.   TOXICOLOGY IN VITRO

“ToxRTool”, a new tool to assess the reliability of toxicological data

(2009) Klaus Schneider et al.   TOXICOLOGY LETTERS

The Roles of Nuclear Receptors CAR and PXR in Hepatic Energy Metabolism

(2008) Yoshihiro Konno et al.   Drug Metabolism and Pharmacokinetics

Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors

(2008) Sergei Romanov et al.   NATURE METHODS

Transforming Environmental Health Protection

(2008) Francis S. Collins et al.   SCIENCE