Adversity Considerations for Thyroid Follicular Cell Hypertrophy and Hyperplasia in Nonclinical Toxicity Studies: Results From the 6th ESTP International Expert Workshop

Practical considerations for developmental thyroid toxicity assessments: What's working, what's not, and how can we do better?

(2019) Abby A. Li et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library

(2018) Jun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Use of Severity Grades to Characterize Histopathologic Changes

(2018) Kenneth A. Schafer et al.   TOXICOLOGIC PATHOLOGY

Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop

(2018) B. Lenz et al.   TOXICOLOGIC PATHOLOGY

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

(2018) Annamaria Brändli-Baiocco et al.   Journal of Toxicologic Pathology

Thyroid hormone disruption in the fetal and neonatal rat: Predictive hormone measures and bioindicators of hormone action in the developing cortex

(2018) K L O’Shaughnessy et al.   TOXICOLOGICAL SCIENCES

Directional thyroid hormone distribution via the blood stream to target sites

(2017) Susanne T. Janssen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Image analysis for TSH mRNA in situ hybridization in pituitary glands from rats with thyroid follicular cell hypertrophy after treatment with three different test compounds

(2017) Juergen Funk et al.   RESEARCH IN VETERINARY SCIENCE

2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum

(2017) Erik K. Alexander et al.   THYROID

Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework

(2017) Iman Hassan et al.   TOXICOLOGICAL SCIENCES

Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity

(2017) Michael W Hornung et al.   TOXICOLOGICAL SCIENCES

Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS)

(2017) Daniel R. Hallinger et al.   TOXICOLOGY IN VITRO

Workshop Report: Crystal City VI—Bioanalytical Method Validation for Biomarkers

(2016) Mark E. Arnold et al.   AAPS Journal

Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology

(2016) Bruno Di Jeso et al.   ENDOCRINE REVIEWS

WOMEN IN CANCER THEMATIC REVIEW: Thyroid-stimulating hormone in thyroid cancer: does it matter?

(2016) Hannah Nieto et al.   ENDOCRINE-RELATED CANCER

Underlying Mechanisms of Pituitary–Thyroid Axis Function Disruption by Chronic Iodine Excess in Rats

(2016) Jamile Calil-Silveira et al.   THYROID

Characterizing “Adversity” of Pathology Findings in Nonclinical Toxicity Studies

(2016) Xavier Palazzi et al.   TOXICOLOGIC PATHOLOGY

Editor’s Highlight: Negative Predictors of Carcinogenicity for Environmental Chemicals

(2016) Thomas Hill et al.   TOXICOLOGICAL SCIENCES

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

(2016) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications

(2016) Xiao-Min Ren et al.   TOXICOLOGY

AAPS and US FDA Crystal City VI workshop on bioanalytical method validation for biomarkers

(2016) Steve Lowes et al.   Bioanalysis

Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study

(2016) Tim I M Korevaar et al.   Lancet Diabetes & Endocrinology

Mode of action and human relevance of pronamide-induced rat thyroid tumors

(2015) Sabitha Papineni et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

(2015) Kostja Renko et al.   THYROID

Scientific and Regulatory Policy Committee (SRPC) Points to Consider

(2015) Kevin A. Keane et al.   TOXICOLOGIC PATHOLOGY

Scientific and Regulatory Policy Committee (SRPC) Review*

(2015) Charles E. Wood et al.   TOXICOLOGIC PATHOLOGY

Scientific and Regulatory Policy Committee

(2015) Roy Kerlin et al.   TOXICOLOGIC PATHOLOGY

Iodine deficiency and thyroid disorders

(2015) Michael B Zimmermann et al.   Lancet Diabetes & Endocrinology

Relevance Weighting of Tier 1 Endocrine Screening Endpoints by Rank Order

(2014) Christopher J. Borgert et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Differential effects of fasting vs food restriction on liver thyroid hormone metabolism in male rats

(2014) E M de Vries et al.   JOURNAL OF ENDOCRINOLOGY

Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors

(2014) D. Rouquié et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Perinatal undernutrition programmes thyroid function in the adult rat offspring

(2013) Rosario Ayala-Moreno et al.   BRITISH JOURNAL OF NUTRITION

Metabolic Profiling Provides a System Understanding of Hypothyroidism in Rats and Its Application

(2013) Si Wu et al.   PLoS One

Interpreting Stress Responses during Routine Toxicity Studies

(2013) Nancy E. Everds et al.   TOXICOLOGIC PATHOLOGY

Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance

(2013) G.A. Montoya et al.   TOXICOLOGY LETTERS

Liver Hypertrophy

(2012) A. P. Hall et al.   TOXICOLOGIC PATHOLOGY

Beyond Low Plasma T3: Local Thyroid Hormone Metabolism during Inflammation and Infection

(2011) Anita Boelen et al.   ENDOCRINE REVIEWS

Lack of Action of Exogenously Administered T3 on the Fetal Rat Brain Despite Expression of the Monocarboxylate Transporter 8

(2011) Carmen Grijota-Martínez et al.   ENDOCRINOLOGY

Thyroid hormone regulation by stress and behavioral differences in adult male rats

(2011) Dana L. Helmreich et al.   HORMONES AND BEHAVIOR

Tyrosine Kinase Inhibitors Noncompetitively Inhibit MCT8-Mediated Iodothyronine Transport

(2011) Doreen Braun et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Developmental thyroid hormone disruption: Prevalence, environmental contaminants and neurodevelopmental consequences

(2011) Mary E. Gilbert et al.   NEUROTOXICOLOGY

Hypothesis-driven weight of evidence framework for evaluating data within the US EPA’s Endocrine Disruptor Screening Program

(2011) Christopher J. Borgert et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Characterization of Xenobiotic-Induced Hepatocellular Enzyme Induction in Rats

(2011) Tanja S. Zabka et al.   TOXICOLOGIC PATHOLOGY

Marginal iodide deficiency and thyroid function: Dose–response analysis for quantitative pharmacokinetic modeling

(2011) M.E. Gilbert et al.   TOXICOLOGY

Perinatal Iron and Copper Deficiencies Alter Neonatal Rat Circulating and Brain Thyroid Hormone Concentrations

(2010) Thomas W. Bastian et al.   ENDOCRINOLOGY

Thyroid cancer gender disparity

(2010) Reza Rahbari et al.   Future Oncology

Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

(2008) M.E. Bette Meek   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Neurodevelopmental and Neurophysiological Actions of Thyroid Hormone

(2008) G. R. Williams   JOURNAL OF NEUROENDOCRINOLOGY