Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library

High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library

(2018) Jun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Developmental Thyroid Hormone Insufficiency Induces a Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study

(2018) Katherine L O’Shaughnessy et al.   TOXICOLOGICAL SCIENCES

The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure

(2018) Erin M Kollitz et al.   TOXICOLOGICAL SCIENCES

Effect of Iodothyronines on Thermogenesis: Focus on Brown Adipose Tissue

(2018) Federica Cioffi et al.   Frontiers in Endocrinology

Adult hippocampal neurogenesis is impaired by transient and moderate developmental thyroid hormone disruption

(2017) M.E. Gilbert et al.   NEUROTOXICOLOGY

Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity

(2017) Michael W Hornung et al.   TOXICOLOGICAL SCIENCES

Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8

(2017) Hongyan Dong et al.   TOXICOLOGY IN VITRO

tcpl: the ToxCast pipeline for high-throughput screening data

(2016) Dayne L. Filer et al.   BIOINFORMATICS

Development and Validation of a Computational Model for Androgen Receptor Activity

(2016) Nicole C. Kleinstreuer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of Thyroid Hormone Disruptors among HO-PBDEs: In Vitro Investigations and Coregulator Involved Simulations

(2016) Qinchang Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

(2016) Richard Judson et al.   TOXICOLOGICAL SCIENCES

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

(2016) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Novel cell-based assay for detection of thyroid receptor beta-interacting environmental contaminants

(2016) Diana A. Stavreva et al.   TOXICOLOGY

Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model

(2015) Patience Browne et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Do children with congenital hypothyroidism exhibit abnormal cortical morphology?

(2015) Hayyah Clairman et al.   PEDIATRIC RESEARCH

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor

(2015) Richard S. Judson et al.   TOXICOLOGICAL SCIENCES

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer

(2014) Minghua Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Omacetaxine: A Protein Translation Inhibitor for Treatment of Chronic Myelogenous Leukemia

(2014) V. Gandhi et al.   CLINICAL CANCER RESEARCH

Treatment With Thyroid Hormone

(2014) Bernadette Biondi et al.   ENDOCRINE REVIEWS

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

(2013) AlberTinka J. Murk et al.   TOXICOLOGY IN VITRO

Omacetaxine as an Anticancer Therapeutic: What is Old is New Again

(2011) Meir Wetzler et al.   CURRENT PHARMACEUTICAL DESIGN

In VivoActivity of the Thyroid Hormone Receptor β- and α-Selective Agonists GC-24 and CO23 on Rat Liver, Heart, and Brain

(2011) Carmen Grijota-Martínez et al.   ENDOCRINOLOGY

Suppression of thyroid hormone receptor-mediated transcription and disruption of thyroid hormone-induced cerebellar morphogenesis by the polybrominated biphenyl mixture, BP-6

(2011) Kingsley Ibhazehiebo et al.   NEUROTOXICOLOGY

Developmental thyroid hormone disruption: Prevalence, environmental contaminants and neurodevelopmental consequences

(2011) Mary E. Gilbert et al.   NEUROTOXICOLOGY

Thyromimetics: A journey from bench to bed-side

(2011) Ivan Tancevski et al.   PHARMACOLOGY & THERAPEUTICS

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

(2010) Natasha Thorne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Molecular Aspects of Thyroid Hormone Actions

(2010) Sheue-Yann Cheng et al.   ENDOCRINE REVIEWS

The Thyroid Hormone Receptor α1 Protein Is Expressed in Embryonic Postmitotic Neurons and Persists in Most Adult Neurons

(2010) Karin Wallis et al.   MOLECULAR ENDOCRINOLOGY

Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay

(2010) Jaime Freitas et al.   TOXICOLOGY IN VITRO

Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months

(2009) Yuanbin Li et al.   CLINICAL ENDOCRINOLOGY

Nuclear Hormone Receptor Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated and Methoxylated Metabolites in Transactivation Assays Using Chinese Hamster Ovary Cells

(2009) Hiroyuki Kojima et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes

(2009) Mark D. Miller et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Role of Halogen Bonds in Thyroid Hormone Receptor Selectivity: Pharmacophore-Based 3D-QSSR Studies

(2009) Napoleão F. Valadares et al.   Journal of Chemical Information and Modeling

Gaining ligand selectivity in thyroid hormone receptors via entropy

(2009) L. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of CCR4 and other essential thyroid hormone receptor co-activators by modified yeast synthetic genetic array analysis

(2009) M. Govindan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed Neurobehavioral Development in Children Born to Pregnant Women with Mild Hypothyroxinemia During the First Month of Gestation: The Importance of Early Iodine Supplementation

(2009) Pere Berbel et al.   THYROID

Interference of Endocrine Disrupters with Thyroid Hormone Receptor–Dependent Transactivation

(2009) Peter Josef Hofmann et al.   TOXICOLOGICAL SCIENCES

Electrophilic α-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones

(2008) J.R. Falck et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of the Functional Domain of Thyroid Hormone Receptor Responsible for Polychlorinated Biphenyl–Mediated Suppression of Its Action in Vitro

(2008) Wataru Miyazaki et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neurodevelopmental and Neurophysiological Actions of Thyroid Hormone

(2008) G. R. Williams   JOURNAL OF NEUROENDOCRINOLOGY

Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment

(2008) Robert J. Kavlock et al.   RISK ANALYSIS