Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals

Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay

(2020) Angela R. Buckalew et al.   ARCHIVES OF TOXICOLOGY

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

(2019) Jun Wang et al.   ENVIRONMENT INTERNATIONAL

Protein Stability Effects in Aggregate-Based Enzyme Inhibition

(2019) Hayarpi Torosyan et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library

(2018) Jun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

High-throughput screening and environmental risk assessment: State of the science and emerging applications

(2018) Daniel L. Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases

(2018) Jennifer H Olker et al.   TOXICOLOGICAL SCIENCES

Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity

(2017) Michael W Hornung et al.   TOXICOLOGICAL SCIENCES

Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS)

(2017) Daniel R. Hallinger et al.   TOXICOLOGY IN VITRO

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

(2016) Ann M. Richard et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Exposure to butachlor causes thyroid endocrine disruption and promotion of metamorphosis in Xenopus laevis

(2016) Shuying Li et al.   CHEMOSPHERE

Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems

(2016) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Impact of co-exposure with butachlor and triadimefon on thyroid endocrine system in larval zebrafish

(2016) Chuyan Cao et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

(2016) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

An Aggregation Advisor for Ligand Discovery

(2015) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

(2015) Kostja Renko et al.   THYROID

Assessment of serum biomarkers in rats after exposure to pesticides of different chemical classes

(2015) Virginia C. Moser et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Enhancing Protein Expression in HEK-293 Cells by Lowering Culture Temperature

(2015) Chi-Yen Lin et al.   PLoS One

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening

(2014) Katie B. Paul et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus)

(2014) Lifei Zhu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

(2014) U. Schweizer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colloidal Aggregation Causes Inhibition of G Protein-Coupled Receptors

(2013) Maria F. Sassano et al.   JOURNAL OF MEDICINAL CHEMISTRY

SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins

(2013) Marco Mariotti et al.   NUCLEIC ACIDS RESEARCH

Identification of Iopanoic Acid as Substrate of Type 1 Deiodinase by a Novel Nonradioactive Iodide-Release Assay

(2012) Kostja Renko et al.   ENDOCRINOLOGY

CYP450-Dependent Biotransformation of the Insecticide Fipronil into Fipronil Sulfone Can Mediate Fipronil-Induced Thyroid Disruption in Rats

(2012) Béatrice B. Roques et al.   TOXICOLOGICAL SCIENCES

Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio)

(2011) Juhua Chang et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Optimization of gene delivery methods in Xenopus laevis kidney (A6) and Chinese hamster ovary (CHO) cell lines for heterologous expression of Xenopus inner ear genes

(2011) Daniel Ramirez-Gordillo et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

(2010) Natasha Thorne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Toxicity Data Landscape for Environmental Chemicals

(2008) Richard Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Xenopus laevis as a model for studying thyroid hormone signalling: From development to metamorphosis

(2008) Ghislaine Morvan-Dubois et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Thyroid Hormone-Inactivating Deiodinase Functions as a Homodimer

(2008) G. D. Vivek Sagar et al.   MOLECULAR ENDOCRINOLOGY

Fipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes

(2008) Julien Leghait et al.   TOXICOLOGY