Promiscuous Effects of Some Phenolic Natural Products on Inflammation at Least in Part Arise from Their Ability to Modulate the Expression of Global Regulators, Namely microRNAs

Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin 2 in Murine Model of Gut Inflammation

(2016) Beng San Yeoh et al.   AMERICAN JOURNAL OF PATHOLOGY

Extract of acai-berry inhibits osteoclast differentiation and activity

(2016) C. Brito et al.   ARCHIVES OF ORAL BIOLOGY

Curcuma longapolyphenols improve insulin-mediated lipid accumulation and attenuate proinflammatory response of 3T3-L1 adipose cells during oxidative stress through regulation of key adipokines and antioxidant enzymes

(2016) Axelle Septembre-Malaterre et al.   BIOFACTORS

Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation

(2016) H.-Y. Xue et al.   BIOSCIENCE REPORTS

Synthesis and Biological Evaluation of Novel Resveratrol-NSAID Derivatives as Anti-inflammatory Agents

(2016) Wei Peng et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Curcumin alleviates renal dysfunction and suppresses inflammation by shifting from M1 to M2 macrophage polarization in daunorubicin induced nephrotoxicity in rats

(2016) Vengadeshprabhu Karuppagounder et al.   CYTOKINE

Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism

(2016) Ayman M. Mahmoud et al.   EUROPEAN JOURNAL OF NUTRITION

Antifungal curcumin promotes chitin accumulation associated with decreased virulence of Sporothrix schenckii

(2016) Lilin Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases

(2016) Nayely Leyva-López et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?

(2016) Feng Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective role of terpenes and polyphenols from three species of Oregano (Lippia graveolens, Lippia palmeri and Hedeoma patens) on the suppression of lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells

(2016) Nayely Leyva-López et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin Blocks Naproxen-Induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats

(2016) Jeong-Hwan Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)

(2016) Jonathan B. Baell   JOURNAL OF NATURAL PRODUCTS

Consumption of Quercetin and Quercetin-Containing Apple and Cherry Extracts Affects Blood Glucose Concentration, Hepatic Metabolism, and Gene Expression Patterns in Obese C57BL/6J High Fat–Fed Mice

(2016) Sarah M Snyder et al.   JOURNAL OF NUTRITION

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

(2016) Brian Collins et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation

(2016) Inhae Kang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anthocyanins as inflammatory modulators and the role of the gut microbiota

(2016) Carina Almeida Morais et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo

(2016) Hyemee Kim et al.   MOLECULAR CARCINOGENESIS

Pterostilbene-induced changes in gut microbiota composition in relation to obesity

(2016) Usune Etxeberria et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Comparison of anti-inflammatory mechanisms of mango (Mangifera IndicaL.) and pomegranate (Punica GranatumL.) in a preclinical model of colitis

(2016) Hyemee Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice

(2016) Sae Im Jeong et al.   NEUROBIOLOGY OF AGING

Involvement of miR-Let7A in inflammatory response and cell survival/apoptosis regulated by resveratrol in THP-1 macrophage

(2016) Juhyun Song et al.   Nutrition Research and Practice

Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review

(2016) M. J. Amiot et al.   Obesity Reviews

The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress

(2016) Olga Krupkova et al.   Oxidative Medicine and Cellular Longevity

Phytochemical screening and anti-inflammatory properties of AlgerianHertia cheirifoliamethanol extract

(2016) Hamama Bouriche et al.   PHARMACEUTICAL BIOLOGY

Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials

(2016) Amirhossein Sahebkar et al.   PHARMACOLOGICAL RESEARCH

Preventive activity of banana peel polyphenols on CCl4-induced experimental hepatic injury in Kunming mice

(2016) RUI WANG et al.   Experimental and Therapeutic Medicine

The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium

(2016) Monica Benvenuto et al.   Nutrients

Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans

(2016) Luis Goya et al.   Nutrients

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

(2016) Tugba Ozdal et al.   Nutrients

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling

(2016) Gang Wang et al.   Oncotarget

Intrahippocampal Administration of Ibotenic Acid Induced Cholinergic Dysfunction via NR2A/NR2B Expression: Implications of Resveratrol against Alzheimer Disease Pathophysiology

(2016) Chennakesavan Karthick et al.   Frontiers in Molecular Neuroscience

Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium

(2016) Sule Caglayan Sozmen et al.   PeerJ

The inhibitory activity of cocoa phenolic extract against pro-inflammatory mediators secretion induced by lipopolysaccharide in RAW 264.7 cells

(2016) Yazan Ranneh et al.   SpringerPlus

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

The Role of Dietary Polyphenols in the Management of Inflammatory Bowel Disease

(2015) Mohammad Farzaei et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review

(2015) Aleksandra Duda-Chodak et al.   EUROPEAN JOURNAL OF NUTRITION

ERK1/2 and HIF1αAre Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis

(2015) Alejandro Cuevas et al.   Evidence-based Complementary and Alternative Medicine

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

(2015) Shatadal Ghosh et al.   FOOD AND CHEMICAL TOXICOLOGY

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

The Intestinal Microbiota in Inflammatory Bowel Disease

(2015) Christoph Becker et al.   ILAR JOURNAL

Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

(2015) Jonathan Bisson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic and Microbial Modulation of the Large Intestine Ecosystem by Non-Absorbed Diet Phenolic Compounds: A Review

(2015) Juana Mosele et al.   MOLECULES

Anti-Proliferative Effects of Polyphenols from Pomegranate Rind (Punica granatumL.) on EJ Bladder Cancer Cells Via Regulation of p53/miR-34a Axis

(2015) Benhong Zhou et al.   PHYTOTHERAPY RESEARCH

Polyphenolic extracts from cowpea (Vigna unguiculata) protect colonic myofibroblasts (CCD18Co cells) from lipopolysaccharide (LPS)-induced inflammation – modulation of microRNA 126

(2015) Leonnard O. Ojwang et al.   Food & Function

Considering Maternal Dietary Modulators for Epigenetic Regulation and Programming of the Fetal Epigenome

(2015) Abalo Chango et al.   Nutrients

Quaking and miR-155 interactions in inflammation and leukemogenesis

(2015) Esmerina Tili et al.   Oncotarget

Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner

(2015) Dimiter B. Avtanski et al.   Oncotarget

A Survey of Modulation of Gut Microbiota by Dietary Polyphenols

(2015) Montserrat Dueñas et al.   Biomed Research International

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

(2015) Laura Marín et al.   Biomed Research International

Green tea polyphenols and their potential role in health and disease

(2015) M. Afzal et al.   INFLAMMOPHARMACOLOGY

Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer

(2015) Hong Zhou et al.   BMC GENOMICS

Identification of microRNAs involved in the modulation of pro-angiogenic factors in atherosclerosis by a polyphenol-rich extract from propolis

(2014) Alejandro Cuevas et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2

(2014) Emanuel Kronski et al.   Molecular Oncology

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Quercetin Inhibits Intestinal Iron Absorption and Ferroportin Transporter Expression In Vivo and In Vitro

(2014) Marija Lesjak et al.   PLoS One

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels

(2014) Chikako Shibata et al.   VIROLOGY

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR

(2013) N. Banerjee et al.   CARCINOGENESIS

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

(2013) Joao Tomé-Carneiro et al.   CURRENT PHARMACEUTICAL DESIGN

MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer

(2013) Esmerina Tili et al.   IMMUNOLOGICAL REVIEWS

Resveratrol repressed viability of U251 cells by miR-21 inhibiting of NF-κB pathway

(2013) Hongxiu Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells

(2013) L. Baselga-Escudero et al.   NUCLEIC ACIDS RESEARCH

Curcumin Intake Affects miRNA Signature in Murine Melanoma with mmu-miR-205-5p Most Significantly Altered

(2013) Indra N. Dahmke et al.   PLoS One

Role of miR-181 family in regulating vascular inflammation and immunity

(2013) Xinghui Sun et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice

(2013) Motoko Ohno et al.   Scientific Reports

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

(2012) João Tomé-Carneiro et al.   AMERICAN JOURNAL OF CARDIOLOGY

The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state

(2012) E. Tili et al.   BLOOD

Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation

(2012) Nivedita Banerjee et al.   BREAST CANCER RESEARCH AND TREATMENT

miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma

(2012) A. L. Kasinski et al.   CANCER RESEARCH

A Novel Regulator of Macrophage Activation

(2012) Guoqing Zhuang et al.   CIRCULATION

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Expression and function of micro RNAs in immune cells during normal or disease state

(2012) Esmerina Tili et al.   International Journal of Medical Sciences

Control of MicroRNA Expression as a New Way for Resveratrol To Deliver Its Beneficial Effects

(2012) Allan Lançon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Grape seed proanthocyanidins repress the hepatic lipid regulators miR-33 and miR-122 in rats

(2012) Laura Baselga-Escudero et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial

(2012) Joao Tomé-Carneiro et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Overexpression of miR-7-1 Increases Efficacy of Green Tea Polyphenols for Induction of Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-DZ Cells

(2012) Mrinmay Chakrabarti et al.   NEUROCHEMICAL RESEARCH

Red wine polyphenolics reduce the expression of inflammation markers in human colon-derived CCD-18Co myofibroblast cells: Potential role of microRNA-126

(2012) Gabriela Angel-Morales et al.   Food & Function

Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells

(2012) Nobuyoshi Kosaka et al.   Frontiers in Genetics

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1 

(2011) H. Wang et al.   CARCINOGENESIS

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

(2011) Lin Zhang et al.   CELL RESEARCH

A trio of microRNAs that control Toll-like receptor signalling

(2011) S. R. Quinn et al.   INTERNATIONAL IMMUNOLOGY

Resveratrol in human cancer chemoprevention - Choosing the ‘right’ dose

(2011) Edwina Scott et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metabolites and tissue distribution of resveratrol in the pig

(2011) María Azorín-Ortuño et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Therapeutic applications of compounds in the Magnolia family

(2011) Young-Jung Lee et al.   PHARMACOLOGY & THERAPEUTICS

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

(2011) E. Tili et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs in autoimmunity and inflammatory bowel disease: Crucial regulators in immune response

(2010) Marisa Iborra et al.   AUTOIMMUNITY REVIEWS

Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells

(2010) Esmerina Tili et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

(2010) Esmerina Tili et al.   CARCINOGENESIS

Involvement of Breast Cancer Resistance Protein (BCRP1/ABCG2) in the Bioavailability and Tissue Distribution oftrans-Resveratrol in Knockout Mice

(2010) Irene Alfaras et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand

(2010) Danish Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Attenuates Behavioral Impairments and Reduces Cortical and Hippocampal Loss in a Rat Controlled Cortical Impact Model of Traumatic Brain Injury

(2010) Richard H. Singleton et al.   JOURNAL OF NEUROTRAUMA

Multidrug Resistance Proteins Restrain the Intestinal Absorption of trans-Resveratrol in Rats

(2010) M. Emília Juan et al.   JOURNAL OF NUTRITION

GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGFβ effectors, Drosha and microRNAs with opposite oncogenic potentials

(2010) Esmerina Tili et al.   NUCLEIC ACIDS RESEARCH

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

(2010) R.H.X. Wong et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The role of microRNA in modulating myocardial ischemia-reperfusion injury

(2010) Yumei Ye et al.   PHYSIOLOGICAL GENOMICS

Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein   are targeted by miR-155 in B cells of E -MiR-155 transgenic mice

(2009) S. Costinean et al.   BLOOD

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

(2009) Ariadne Androulidaki et al.   IMMUNITY

miR-155: On the Crosstalk Between Inflammation and Cancer

(2009) Esmerina Tili et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

Hypoxia response and microRNAs: no longer two separate worlds

(2008) Mircea Ivan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Advances in microRNAs: implications for immunity and inflammatory diseases

(2008) E. Sonkoly et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol

(2008) K. van de Wetering et al.   MOLECULAR PHARMACOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Small non-coding RNAs in animal development

(2008) Giovanni Stefani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNAs, the immune system and rheumatic disease

(2008) Esmerina Tili et al.   Nature clinical practice. Rheumatology