Multivalent Carbohydrate-Lectin Interactions: How Synthetic Chemistry Enables Insights into Nanometric Recognition

Galectins and Immune Responses—Just How Do They Do Those Things They Do?

(2016) Sandra Thiemann et al.   Annual Review of Immunology

Sweet complementarity: the functional pairing of glycans with lectins

(2016) H.-J. Gabius et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB–Regulated Gene Network

(2016) Stefan Toegel et al.   JOURNAL OF IMMUNOLOGY

Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet

(2016) Pablo F. Hockl et al.   PHARMACOLOGICAL RESEARCH

Onion-like glycodendrimersomes from sequence-defined Janus glycodendrimers and influence of architecture on reactivity to a lectin

(2016) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes

(2016) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting Molecular Aspects of Cell Interactions Using Glycodendrimersomes with Programmable Glycan Presentation and Engineered Human Lectins

(2015) Shaodong Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code

(2015) Dolores Solís et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Thio- and selenoglycosides as ligands for biomedically relevant lectins: Valency–activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides

(2015) Sabine André et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity

(2015) Michael D. Swanson et al.   CELL

Glyconanosynthons as powerful scaffolds and building blocks for the rapid construction of multifaceted, dense and chiral dendrimers

(2015) René Roy et al.   CHEMICAL SOCIETY REVIEWS

Combining Crystallography and Hydrogen-Deuterium Exchange to Study Galectin-Ligand Complexes

(2015) Federico M. Ruiz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Comparative lectinology: Delineating glycan-specificity profiles of the chicken galectins using neoglycoconjugates in a cell assay

(2015) E. M. Rapoport et al.   GLYCOBIOLOGY

Glycan microarrays of fluorescently-tagged natural glycans

(2015) Xuezheng Song et al.   GLYCOCONJUGATE JOURNAL

Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context

(2015) Sabine André et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Glycodendrimersomes from Sequence-Defined Janus Glycodendrimers Reveal High Activity and Sensor Capacity for the Agglutination by Natural Variants of Human Lectins

(2015) Shaodong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lectins: Getting Familiar with Translators of the Sugar Code

(2015) Sabine André et al.   MOLECULES

Do plant cell walls have a code?

(2015) Eveline Q.P. Tavares et al.   PLANT SCIENCE

Multifaceted glycodendrimers with programmable bioactivity through convergent, divergent, and accelerated approaches using polyfunctional cyclotriphosphazenes

(2015) Leïla Abbassi et al.   Polymer Chemistry

A fast track strategy toward highly functionalized dendrimers with different structural layers: an “onion peel approach”

(2015) Rishi Sharma et al.   Polymer Chemistry

Unraveling functional significance of natural variations of a human galectin by glycodendrimersomes with programmable glycan surface

(2015) Shaodong Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sugar coating: bacterial protein glycosylation and host–microbe interactions

(2015) Felicia Y.Y. Tan et al.   TRENDS IN BIOCHEMICAL SCIENCES

The magic of the sugar code

(2015) Hans-Joachim Gabius   TRENDS IN BIOCHEMICAL SCIENCES

The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function

(2015) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

The multi-tasked life of GM1 ganglioside, a true factotum of nature

(2015) Robert W. Ledeen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glycan variation and evolution in the eukaryotes

(2015) Anthony P. Corfield et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gangliosides: glycosphingolipids essential for normal neural development and function

(2015) Cara-Lynne Schengrund   TRENDS IN BIOCHEMICAL SCIENCES

Glycan microarrays: new angles and new strategies

(2014) Boglarka Donczo et al.   ANALYST

Human chimera-type galectin-3: Defining the critical tail length for high-affinity glycoprotein/cell surface binding and functional competition with galectin-1 in neuroblastoma cell growth regulation

(2014) Jürgen Kopitz et al.   BIOCHIMIE

Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)

(2014) Sabine André et al.   CARBOHYDRATE RESEARCH

Defining the Potential of Aglycone Modifications for Affinity/Selectivity Enhancement against Medically Relevant Lectins: Synthesis, Activity Screening, and HSQC-Based NMR Analysis

(2014) Subhash R. Rauthu et al.   CHEMBIOCHEM

A highly versatile convergent/divergent “onion peel” synthetic strategy toward potent multivalent glycodendrimers

(2014) Rishi Sharma et al.   CHEMICAL COMMUNICATIONS

Chemistry of natural glycan microarrays

(2014) Xuezheng Song et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Glycan arrays as tools for infectious disease research

(2014) Andreas Geissner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells

(2014) Federico M. Ruiz et al.   FEBS Journal

Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration

(2014) Stefan Toegel et al.   HISTOCHEMISTRY AND CELL BIOLOGY

“Onion peel” dendrimers: a straightforward synthetic approach towards highly diversified architectures

(2014) Rishi Sharma et al.   Polymer Chemistry

Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

(2013) Yoann M. Chabre et al.   CHEMICAL SOCIETY REVIEWS

Copy-number variation of functional galectin genes: Studying animal galectin-7 (p53-induced gene 1 in man) and tandem-repeat-type galectins-4 and -9

(2013) Herbert Kaltner et al.   GLYCOBIOLOGY

Modular Synthesis of Amphiphilic Janus Glycodendrimers and Their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins

(2013) Virgil Percec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity

(2013) Paul Murphy et al.   MOLECULES

Aromatic thioglycoside inhibitors against the virulence factor LecA from Pseudomonas aeruginosa

(2013) Jacques Rodrigue et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1

(2012) Robert W. Ledeen et al.   Annals of the New York Academy of Sciences

Galectins in acute and chronic inflammation

(2012) Fu-Tong Liu et al.   Annals of the New York Academy of Sciences

Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: Association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population

(2012) Zsuzsanna Pál et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Tumour suppressor p16INK4a- anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

(2012) Maho Amano et al.   FEBS Journal

Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9

(2012) Olga A Vokhmyanina et al.   GLYCOBIOLOGY

Evolution of Siglec-11 and Siglec-16 Genes in Hominins

(2012) Xiaoxia Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity

(2012) Guan-Nan Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibitory potential of chemical substitutions at bioinspired sites of β-d-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins

(2011) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons

(2011) Sabine André et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

(2011) Sabine André et al.   CHEMICAL COMMUNICATIONS

Inhibition of Galectins with Small Molecules

(2011) Christopher T. Öberg et al.   CHIMIA

Galectin-8-N-domain Recognition Mechanism for Sialylated and Sulfated Glycans

(2011) Hiroko Ideo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells

(2011) Sabine André et al.   JOURNAL OF PEPTIDE SCIENCE

From lectin structure to functional glycomics: principles of the sugar code

(2011) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human galectin-3 (Mac-2 antigen): Defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

(2010) Mickaël Krzeminski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin

(2010) H Sanchez-Ruderisch et al.   CELL DEATH AND DIFFERENTIATION

Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

(2010) Hugo Sanchez-Ruderisch et al.   FEBS Journal

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

(2010) Huan Cao et al.   IMMUNOLOGY

Selenoglycosides in silico: ab initio-derived reparameterization of MM4, conformational analysis using histo-blood group ABH antigens and lectin docking as indication for potential of bioactivity

(2010) Francesco Strino et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Hexaphenylbenzene as a Rigid Template for the Straightforward Syntheses of “Star-Shaped” Glycodendrimers

(2010) Yoann M. Chabre et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and screening of a small glycomimetic library for inhibitory activity on medically relevant galactoside-specific lectins in assays of increasing biorelevance

(2010) Sabine André et al.   NEW JOURNAL OF CHEMISTRY

Lectin Microarrays for Glycomic Analysis

(2010) Garima Gupta et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Ultrasound-assisted synthesis of C-glycosides

(2010) Dilip V. Jarikote et al.   TETRAHEDRON LETTERS

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans

(2009) Sabine André et al.   BIOLOGICAL CHEMISTRY

Synthesis of Bivalent Lactosides Based on Terephthalamide,N,N′-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins

(2009) Rosaria Leyden et al.   JOURNAL OF ORGANIC CHEMISTRY

Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles

(2009) Sabine André et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of stable and selective inhibitors of human galectins-1 and -3

(2008) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Calix[n]arene‐Based Glycoclusters: Bioactivity of Thiourea‐Linked Galactose/Lactose Moieties as Inhibitors of Binding of Medically Relevant Lectins to a Glycoprotein and Cell‐Surface Glycoconjugates and Selectivity among Human Adhesion/Growth‐Regulatory Galectins

(2008) Sabine André et al.   CHEMBIOCHEM

Dimeric Galectin-8 Induces Phosphatidylserine Exposure in Leukocytes through Polylactosamine Recognition by the C-terminal Domain

(2008) Sean R. Stowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens

(2008) Sean R. Stowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expeditive Synthesis of Glycodendrimer Scaffolds Based on Versatile TRIS and Mannoside Derivatives

(2008) Yoann M. Chabre et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent Advances on Cyclopeptide-Based Glycoclusters

(2008) Olivier Renaudet   MINI-REVIEWS IN ORGANIC CHEMISTRY