The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

(2013) Karel Smetana et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1

(2012) Robert W. Ledeen et al.   Annals of the New York Academy of Sciences

Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: Different structural alterations upon oxidation and ligand binding

(2012) Antonia Göhler et al.   BIOCHIMIE

Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins

(2012) Samy Cecioni et al.   CARBOHYDRATE RESEARCH

Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour-Associated Galectins

(2012) Marco Bartoloni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tumour suppressor p16INK4a- anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

(2012) Maho Amano et al.   FEBS Journal

Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9

(2012) Olga A Vokhmyanina et al.   GLYCOBIOLOGY

Developmental diseases caused by impaired nucleotide sugar transporters

(2012) Li Liu et al.   GLYCOCONJUGATE JOURNAL

Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations

(2012) Ursula Schlötzer-Schrehardt et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Strained cyclophane natural products: Macrocyclization at its limits

(2012) Tanja Gulder et al.   NATURAL PRODUCT REPORTS

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ganglioside GM1/Galectin-Dependent Growth Regulation in Human Neuroblastoma Cells: Special Properties of Bivalent Galectin-4 and Significance of Linker Length for Ligand Selection

(2012) Jürgen Kopitz et al.   NEUROCHEMICAL RESEARCH

Bi- to tetravalent glycoclusters: synthesis, structure–activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity

(2012) Guan-Nan Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Why nature chose phosphate to modify proteins

(2012) T. Hunter   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Modifications of Glycans: Biological Significance and Therapeutic Opportunities

(2011) Saddam M. Muthana et al.   ACS Chemical Biology

Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy

(2011) Antonia Göhler et al.   ANALYST

Toward Comprehensive Analysis of the Galectin Network in Chicken: Unique Diversity of Galectin-3 and Comparison of its Localization Profile in Organs of Adult Animals to the Other Four Members of this Lectin Family

(2011) Herbert Kaltner et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Inhibitory potential of chemical substitutions at bioinspired sites of β-d-galactopyranose on neoglycoprotein/cell surface binding of two classes of medically relevant lectins

(2011) Denis Giguère et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons

(2011) Sabine André et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes

(2011) Sabine André et al.   CHEMICAL COMMUNICATIONS

Ganglioside GM1 Deficiency in Effector T Cells From NOD Mice Induces Resistance to Regulatory T-Cell Suppression

(2011) G. Wu et al.   DIABETES

Fucose, placental evolution and the glycocode

(2011) J. D. Aplin et al.   GLYCOBIOLOGY

Structural aspects of binding of α-linked digalactosides to human galectin-1

(2011) Michelle C Miller et al.   GLYCOBIOLOGY

Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy

(2011) Felix A. Habermann et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential

(2011) Myriam Remmelink et al.   HISTOPATHOLOGY

Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells

(2011) Sabine André et al.   JOURNAL OF PEPTIDE SCIENCE

Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins

(2011) Sonsoles Martín-Santamaría et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Post-translation modification of proteins; methodologies and applications in plant sciences

(2011) A.E. Bond et al.   PHYTOCHEMISTRY

From lectin structure to functional glycomics: principles of the sugar code

(2011) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

The How and Why of Ca2+ Involvement in Lectin Activity

(2011) Hans-Joachim Gabius   TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY

Human galectin-3 (Mac-2 antigen): Defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

(2010) Mickaël Krzeminski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metathesis and Macrocycles with Embedded Carbohydrates

(2010) Dilip Venkatrao Jarikote et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model

(2010) Hugo Sanchez-Ruderisch et al.   FEBS Journal

N-domain of human adhesion/growth-regulatory galectin-9: Preference for distinct conformers and non-sialylated N-glycans and detection of ligand-induced structural changes in crystal and solution

(2010) Dolores Solís et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: Case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane

(2010) Jürgen Kopitz et al.   IUBMB LIFE

Exploring genomes for glycosyltransferases

(2010) Sara Fasmer Hansen et al.   Molecular BioSystems

Synthesis and screening of a small glycomimetic library for inhibitory activity on medically relevant galactoside-specific lectins in assays of increasing biorelevance

(2010) Sabine André et al.   NEW JOURNAL OF CHEMISTRY

Unique Chicken Tandem-Repeat-Type Galectin: Implications of Alternative Splicing and a Distinct Expression Profile Compared to Those of the Three Proto-Type Proteins

(2009) Herbert Kaltner et al.   BIOCHEMISTRY

Carbamate-Linked Lactose: Design of Clusters and Evidence for Selectivity to Block Binding of Human Lectins to (Neo)Glycoproteins with Increasing Degree of Branching and to Tumor Cells

(2009) Sabine André et al.   BIOCONJUGATE CHEMISTRY

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans

(2009) Sabine André et al.   BIOLOGICAL CHEMISTRY

Carbohydrate analysis throughout the development of a protein therapeutic

(2009) Elizabeth Higgins   GLYCOCONJUGATE JOURNAL

Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Synthesis of Bivalent Lactosides Based on Terephthalamide,N,N′-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins

(2009) Rosaria Leyden et al.   JOURNAL OF ORGANIC CHEMISTRY

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles

(2009) Sabine André et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Galectin-4-Regulated Delivery of Glycoproteins to the Brush Border Membrane of Enterocyte-Like Cells

(2009) Laurence Stechly et al.   TRAFFIC

Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

(2008) Herbert Kaltner et al.   BIOCHEMICAL JOURNAL

Characterization of Mouse Sialyltransferase Genes: Their Evolution and Diversity

(2008) Shou TAKASHIMA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Calix[n]arene‐Based Glycoclusters: Bioactivity of Thiourea‐Linked Galactose/Lactose Moieties as Inhibitors of Binding of Medically Relevant Lectins to a Glycoprotein and Cell‐Surface Glycoconjugates and Selectivity among Human Adhesion/Growth‐Regulatory Galectins

(2008) Sabine André et al.   CHEMBIOCHEM

Galectin-1 Is a Novel Functional Receptor for Tissue Plasminogen Activator in Pancreatic Cancer

(2008) Oriol Roda et al.   GASTROENTEROLOGY

Dimeric Galectin-8 Induces Phosphatidylserine Exposure in Leukocytes through Polylactosamine Recognition by the C-terminal Domain

(2008) Sean R. Stowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Advances on Cyclopeptide-Based Glycoclusters

(2008) Olivier Renaudet   MINI-REVIEWS IN ORGANIC CHEMISTRY