Article
Biotechnology & Applied Microbiology
Dencil Basumatary, Shilpa Saikia, Hardeo Singh Yadav, Meera Yadav
Summary: This study utilized a bioinformatics approach to investigate the structural and functional aspects of luffa peroxidase (LPrx) from Luffa acutangula. The evolutionary relationship of LPrx with other class III peroxidases was studied through constructing a phylogenetic tree. The results of this study have significant implications in proteomics, biochemistry, biotechnology, and the potential applications of peroxidases in the biotransformations of organic compounds.
Article
Immunology
Aleksei Parshenkov, Thierry Hennet
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bohdana Kokhanyuk, Viola Bagone Vantus, Balazs Radnai, Eszter Vamos, Gyula Kajner, Gabor Galbacs, Elek Telek, Maria Meszaros, Maria A. Deli, Peter Nemeth, Peter Engelmann
Summary: This study compares the mechanisms of silver nanoparticle uptake in human immune cells and earthworm immune cells. It reveals different endocytosis pathways utilized by these cells and provides insights into the localization of silver nanoparticles in the cells as well as their impact on mitochondrial respiration.
Article
Biochemistry & Molecular Biology
Cindy Y. Kok, Lauren M. MacLean, Renuka Rao, Shinya Tsurusaki, Eddy Kizana
Summary: The study aimed to identify a gene that can be delivered to the heart to protect against cancer therapy-induced cardiotoxicity. By replacing the CMV promoter with the cardiac-specific NCX1 promoter, a lentiviral vector capable of inducing the expression of cardioprotective gene Bcl-2 was successfully produced.
Article
Biochemistry & Molecular Biology
Eugenia Rita Lauriano, Alessio Alesci, Marialuisa Aragona, Simona Pergolizzi, Anthea Miller, Kristina Zuwala, Michal Kuciel, Giacomo Zaccone, Antonino Germana, Maria Cristina Guerrera
Summary: This study characterizes the leukocytes present in the gut-associated lymphoid tissue (GALT) of H. niloticus for the first time using confocal immuno-fluorescence techniques. The results show massive aggregates of immune cells in the submucosal thickness, forming oval-shaped structures similar to isolated lymphoid follicles found in birds and mammals. This expands our understanding of intestinal immunity in this fish.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Kamel Atrouz, Ratiba Bousba, Francesco Paolo Marra, Annalisa Marchese, Francesca Luisa Conforti, Benedetta Perrone, Hamza Harkat, Amelia Salimonti, Samanta Zelasco
Summary: Genetic characterization studies of Algerian olive accessions provide insights into the diversification process of olives in the Mediterranean basin. The research also reveals genetic relationships among olive germplasm in the Central-Western Mediterranean area and highlights new synthesis cases and recent admixture events.
Article
Integrative & Complementary Medicine
Luo Yu, Zeng Lin-Jie, Liu Xiao-Qin, Li Lu, Zeng Qi-Yan
Summary: In this study, a novel lectin AHL was isolated from Artocarpus hypargyreus Hance and its immunomodulatory and antitumor activities were demonstrated. AHL showed strong binding affinity to cell membrane and inhibited cell proliferation through apoptosis pathway, with involvement of ERK and p38 signaling pathways.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Dayane Correia Gomes, Marcela Rodrigues Barros, Thais Meira Menezes, Jorge Luiz Neves, Patricia Maria Guedes Paiva, Teresinha Goncalves da Silva, Thiago Henrique Napoleao, Marilia Cavalcanti Coriolano, Maria Tereza dos Santos Correia
Summary: EgviL is a cytotoxic protein from Egletes viscosa plant, with toxic effect on leukemic cells and ability to bind to galactose and glucose.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Infectious Diseases
Patrizia Cavadini, Stefano Molinari, Francesca Merzoni, Alice Vismarra, Annika Posautz, Vanesa Alzaga Gil, Mario Chiari, Francesca Giannini, Lorenzo Capucci, Antonio Lavazza
Summary: The Lagovirus genus includes pathogenic viruses like European brown hare syndrome virus and rabbit hemorrhagic disease viruses, as well as non-pathogenic agents like rabbit calicivirus and hare calicivirus. A study conducted in multiple European countries found that the non-pathogenic hare calicivirus (HaCV) has been circulating widely in Europe, with a relatively high level of genetic variation within the cluster.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Review
Cell Biology
Huldani Huldani, Ahmed Ibraheem Rashid, Khikmatulla Negmatovich Turaev, Maria Jade Catalan Opulencia, Walid Kamal Abdelbasset, Dmitry Olegovich Bokov, Yasser Fakri Mustafa, Moaed E. Al-Gazally, Ali Thaeer Hammid, Mustafa M. Kadhim, Seyed Hossein Ahmadi
Summary: Concanavalin A (ConA) is a potent anti-neoplastic agent that can induce autophagy and apoptosis in various cancer cell types. It modulates signaling cascades and immune cell function, with the most studied host receptor being MT1-MMP. However, liver injury is the most significant side effect of ConA.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Bruno Rafael Barboza, Sandra Maria de Oliveira Thomaz, Airton de Carvalho, Enilza Maria Espreafico, Jackson Gabriel Miyamoto, Alexandre Keiji Tashima, Mauricio Frota Camacho, Andre Zelanis, Maria Cristina Roque-Barreira, Thiago Aparecido da Silva
Summary: ArtinM, a lectin protein, binds to N-glycans on immune cell receptors and induces apoptosis in B cells derived from non-Hodgkin's lymphoma through its interaction with TLR2/CD14 N-glycans and CD3 gamma N-glycans. This cytotoxic effect is regulated by the phosphatase CD45 and the Src family protein kinases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xianghan Mei, Chun Li, Peilin Peng, Jue Wang, Enxi He, Zhiyong Qiu, Dingguo Xia, Qiaoling Zhao, Dongxu Shen
Summary: In this study, a C-type lectin gene called BmIML-2 was identified from the silkworm Bombyx mori. It was found that BmIML-2 can inhibit the proliferation of the BmNPV virus by facilitating cell apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yang He, Tao Zhao, Fang Chen, Changchun Song, Chongchao Zhong, Zhi Luo
Summary: This study identified the effects of zinc on the promoter regions of Bcl-2 and Cycs in yellow catfish, revealing MTF-1 and HNF-1 alpha as key transcription factors regulating the activity of these promoters. The findings suggest a novel mechanism by which zinc influences apoptosis in vertebrates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Eliana Dell'Olmo, Pasquale Tripodi, Massimo Zaccardelli, Loredana Sigillo
Summary: Climate change has caused the spread of plant pathogens in new environments, resulting in crop losses and economic damage. The study focuses on Macrophomina, a fungal family that can infect various hosts. The research identifies Macrophomina as the pathogen responsible for crown charcoal rot in chickpeas in Italy and utilizes a multidisciplinary approach to characterize and test its pathogenicity.
Article
Anatomy & Morphology
Joachim C. Manning, Gabriel Garcia Caballero, Clemens Knospe, Herbert Kaltner, Hans-Joachim Gabius
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2018)
Review
Cell Biology
Herbert Kaltner, Gabriel Garcia Caballero, Anna-Kristin Ludwig, Joachim C. Manning, Hans-Joachim Gabius
HISTOCHEMISTRY AND CELL BIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Joachim C. Manning, Gabriel Garcia Caballero, Federico M. Ruiz, Antonio Romero, Herbert Kaltner, Hans-Joachim Gabius
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY
(2018)
Article
Cell Biology
Gabriel Garcia Caballero, Sebastian Schmidt, Martina Schnoelzer, Ursula Schloetzer-Schrehardt, Clemens Knospe, Anna-Kristin Ludwig, Joachim C. Manning, Paul Muschler, Herbert Kaltner, Juergen Kopitz, Hans-Joachim Gabius
CELL AND TISSUE RESEARCH
(2019)
Article
Cell Biology
Gabriel Garcia Caballero, Sebastian Schmidt, Joachim C. Manning, Malwina Michalak, Ursula Schloetzer-Schrehardt, Anna-Kristin Ludwig, Herbert Kaltner, Fred Sinowatz, Martina Schnoelzer, Juergen Kopitz, Hans-Joachim Gabius
CELL AND TISSUE RESEARCH
(2020)
Article
Cell Biology
Gabriel Garcia Caballero, Donella Beckwith, Nadezhda Shilova, Adele Gabba, Tanja J. Kutzner, Anna-Kristin Ludwig, Joachim C. Manning, Herbert Kaltner, Fred Sinowatz, Mare Cudic, Nicolai Bovin, Paul Murphy, Hans-Joachim Gabius
HISTOCHEMISTRY AND CELL BIOLOGY
(2020)
Article
Anatomy & Morphology
Joachim C. Manning, Gabriel Garcia Caballero, Anna-Kristin Ludwig, Herbert Kaltner, Fred Sinowatz, Hans-Joachim Gabius
Summary: The study comprehensively characterized galectin expression during chicken nephrogenesis using immunohistochemistry and mapping binding sites. Differences between plant lectins and galectins were revealed, showing selectivity in binding to beta-galactosides. The presence and complexity of beta-galactosides and galectins during organogenesis provide guidelines for functional assays using supramolecular tools.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2021)
Review
Cell Biology
Felix A. Habermann, Herbert Kaltner, Alonso M. Higuero, Gabriel Garcia Caballero, Anna-Kristin Ludwig, Joachim C. Manning, Jose Abad-Rodriguez, Hans-Joachim Gabius
Summary: Biochemical 'symbols' like sugars play a crucial role in cell communication and biological processes, with their interactions with lectins dictating important biological functions. By studying glycophenotyping and lectin expression in cells and tissues, researchers can uncover important correlations related to cell adhesion, apoptosis, autophagy, growth regulation, and targeted delivery of glycoproteins. The ultimate goal is to decipher the sugar code by compiling a dictionary that translates each oligosaccharide message into its corresponding biological response.
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2021)
Article
Cell Biology
Anna-Kristin Ludwig, Malwina Michalak, Adele Gabba, Tanja J. Kutzner, Donella M. Beckwith, Forrest G. FitzGerald, Gabriel Garcia Caballero, Joachim C. Manning, Mark Kriegsmann, Herbert Kaltner, Paul Murphy, Mare Cudic, Juergen Kopitz, Hans-Joachim Gabius
Summary: Wild-type lectins have distinct modular designs. This study explores the effects of homodimers and heterodimers of galectins on cell binding properties and activities. The results show that heterodimers exhibit altered properties, with the arrangement of lectin domains and linker length affecting effector activity.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Biographical-Item
Cell Biology
Herbert Kaltner, Joachim C. Manning, Jurgen Kopitz, Anthony Corfield
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Malwina Michalak, Viola Golde, Dominik Helm, Herbert Kaltner, Johannes Gebert, Jurgen Kopitz
Summary: In this study, the researchers explored the function of tumor suppressor protein Gal4 in colorectal cancer (CRC) and found that Gal4 can influence nucleic acid-binding proteins in the nucleus and regulate the expression and activity of proteins involved in transcriptional and translational control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joachim C. Manning, Veronica Baldoneschi, Laura L. Romero-Hern, Katharina M. Pichler, Gabriel GarcIa Caballero, Sabine Andr, Tanja J. Kutzner, Anna-Kristin Ludwig, Valerio Zullo, Barbara Richichi, Reinhard Windhager, Herbert Kaltner, Stefan Toegel, Hans-Joachim Gabius, Paul V. Murphy, Cristina Nativi
Summary: Pairing glycans with tissue lectins can regulate multiple effector pathways in (patho)physiology, and it is particularly important in the progression of osteoarthritis. Designing inhibitors that can block galectin binding and matrix metalloproteinases (MMPs) has the potential to dissect the roles of lectins and proteolytic enzymes. Testing these inhibitors on clinical material has shown promising results in reducing galectin binding to osteoarthritis specimens.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Matus Coma, Joachim C. Manning, Herbert Kaltner, Peter Gal
Summary: Understanding the molecular and cellular processes involved in skin wound healing is important for developing innovative therapeutic tools. Galectins are involved in various cell-cell and cell-matrix interactions, and play a role in different phases of skin repair. Engineering galectins may produce new tools with multiple applications.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Review
Cell Biology
Gabriel Garcia Caballero, Herbert Kaltner, Tanja J. Kutzner, Anna-Kristin Ludwig, Joachim C. Manning, Sebastian Schmidt, Fred Sinowatz, Hans-Joachim Gabius
HISTOLOGY AND HISTOPATHOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Tanja J. Kutzner, Adele Gabba, Forrest G. FitzGerald, Nadezhda Shilova, Gabriel Garcia Caballero, Anna-Kristin Ludwig, Joachim C. Manning, Clemens Knospe, Herbert Kaltner, Fred Sinowatz, Paul Murphy, Mare Cudic, Nicolai Bovin, Hans-Joachim Gabius