Clinical and Treatment Considerations for the Pediatric and Aging Patients with Multiple Sclerosis

Gene–environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures

(2023) Zahra Nasr et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria

(2023) Brenda Banwell et al.   LANCET NEUROLOGY

Deviation From Normative Whole Brain and Deep Gray Matter Growth in Children With MOGAD, MS, and Monophasic Seronegative Demyelination

(2023) Giulia Fadda et al.   NEUROLOGY

Association of Higher Ocrelizumab Exposure With Reduced Disability Progression in Multiple Sclerosis

(2023) Stephen L. Hauser et al.   Neurology-Neuroimmunology & Neuroinflammation

Gene–environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution

(2022) Amin Ziaei et al.   Multiple Sclerosis Journal

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

(2022) Kjetil Bjornevik et al.   SCIENCE

Exercise-induced increase in blood-based brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis: A systematic review and meta-analysis of exercise intervention trials

(2022) Parnian Shobeiri et al.   PLoS One

Disease correlates of rim lesions on quantitative susceptibility mapping in multiple sclerosis

(2022) Melanie Marcille et al.   Scientific Reports

A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial

(2022) Riley Bove et al.   Multiple Sclerosis and Related Disorders

Physical and Mental Health-Related Quality of Life Trajectories Among People With Multiple Sclerosis

(2022) Julia O'Mahony et al.   NEUROLOGY

Bruton’s Tyrosine Kinase Inhibitors in Multiple Sclerosis: Pioneering the Path Towards Treatment of Progression?

(2022) Anastasia Geladaris et al.   CNS DRUGS

Bruton’s Tyrosine Kinase Inhibition in Multiple Sclerosis

(2022) Raphael Schneider et al.   Current Neurology and Neuroscience Reports

Ageing and multiple sclerosis

(2022) Jennifer S Graves et al.   LANCET NEUROLOGY

A new look at cognitive functioning in pediatric MS

(2022) Lauren B Krupp et al.   Multiple Sclerosis Journal

Multiple sclerosis progression: time for a new mechanism-driven framework

(2022) Tanja Kuhlmann et al.   LANCET NEUROLOGY

Identifying the Distinct Cognitive Phenotypes in Multiple Sclerosis

(2021) Ermelinda De Meo et al.   JAMA Neurology

Paediatric multiple sclerosis and antibody-associated demyelination: clinical, imaging, and biological considerations for diagnosis and care

(2021) Giulia Fadda et al.   LANCET NEUROLOGY

Leukocyte Telomere Length in Patients with Multiple Sclerosis and Its Association with Clinical Phenotypes

(2021) Michael Hecker et al.   MOLECULAR NEUROBIOLOGY

Stopping disease-modifying therapy in relapsing and progressive multiple sclerosis

(2021) Hans-Peter Hartung et al.   CURRENT OPINION IN NEUROLOGY

Clinical Features of Late-Onset Multiple Sclerosis: a Systematic Review and Meta-analysis

(2021) Amirreza Naseri et al.   Multiple Sclerosis and Related Disorders

Effects of Menopause in Women With Multiple Sclerosis: An Evidence-Based Review

(2021) Riley Bove et al.   Frontiers in Neurology

Gene-Environment Interactions in Multiple Sclerosis

(2021) Benjamin Meir Jacobs et al.   Neurology-Neuroimmunology & Neuroinflammation

Safety and efficacy of teriflunomide in paediatric multiple sclerosis (TERIKIDS): a multicentre, double-blind, phase 3, randomised, placebo-controlled trial

(2021) Tanuja Chitnis et al.   LANCET NEUROLOGY

Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis

(2021) Susana Otero-Romero et al.   Multiple Sclerosis Journal

Health Disparities, Inequities, and Social Determinants of Health in Multiple Sclerosis and Related Disorders in the US

(2021) Lilyana Amezcua et al.   JAMA Neurology

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

(2020) Jeremy Chataway et al.   LANCET NEUROLOGY

Real‐World Effectiveness of Initial Disease‐Modifying Therapies in Pediatric Multiple Sclerosis

(2020) Kristen M. Krysko et al.   ANNALS OF NEUROLOGY

Impact of Age on Multiple Sclerosis Disease Activity and Progression

(2020) Burcu Zeydan et al.   Current Neurology and Neuroscience Reports

Association between shorter leukocyte telomeres and multiple sclerosis

(2020) Raneem Habib et al.   JOURNAL OF NEUROIMMUNOLOGY

Exercise and lifestyle physical activity recommendations for people with multiple sclerosis throughout the disease course

(2020) Rosalind Kalb et al.   Multiple Sclerosis Journal

SeXX Matters in Multiple Sclerosis

(2020) Francesca Gilli et al.   Frontiers in Neurology

Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships

(2020) Ruth Geraldes et al.   BRAIN

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Bruce A C Cree et al.   LANCET NEUROLOGY

Epidemiology of pediatric multiple sclerosis: A systematic literature review and meta-analysis

(2020) Kevin Yan et al.   Multiple Sclerosis and Related Disorders

The effects of aging and disease duration on cognition in multiple sclerosis

(2020) Tremblay Alexandra et al.   BRAIN AND COGNITION

Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry

(2019) Calvin Chi et al.   PLoS Genetics

The prevalence of MS in the United States

(2019) Mitchell T. Wallin et al.   NEUROLOGY

Benefits of Physical Activity for Depression and Fatigue in Multiple Sclerosis: A Longitudinal Analysis

(2019) Samantha Stephens et al.   JOURNAL OF PEDIATRICS

Epidemiology and treatment of multiple sclerosis in elderly populations

(2019) Caila B. Vaughn et al.   Nature Reviews Neurology

Age and the risks of high-efficacy disease modifying drugs in multiple sclerosis

(2019) Finja Schweitzer et al.   CURRENT OPINION IN NEUROLOGY

Impact of natural menopause on multiple sclerosis: a multicentre study

(2019) Damiano Baroncini et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Early effective treatment may protect from cognitive decline in paediatric multiple sclerosis

(2019) A. Johnen et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Telomere Length Is Associated with Disability Progression in Multiple Sclerosis

(2019) Kristen M. Krysko et al.   ANNALS OF NEUROLOGY

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

(2019) Björn Neumann et al.   Cell Stem Cell

Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis

(2019) Eleftheria Theodoropoulou et al.   Epigenomics

Therapies for mobility disability in persons with multiple sclerosis

(2018) Jessica F. Baird et al.   Expert Review of Neurotherapeutics

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk

(2018) Amy M Lavery et al.   Multiple Sclerosis Journal

Discontinuation of disease-modifying therapy in patients with multiple sclerosis over age 60

(2018) Le H Hua et al.   Multiple Sclerosis Journal

Therapies for mobility disability in persons with multiple sclerosis

(2018) Jessica F. Baird et al.   Expert Review of Neurotherapeutics

The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk

(2018) Amy M Lavery et al.   Multiple Sclerosis Journal

Discontinuation of disease-modifying therapy in patients with multiple sclerosis over age 60

(2018) Le H Hua et al.   Multiple Sclerosis Journal

The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults

(2018) Jennifer S. Graves et al.   Multiple Sclerosis and Related Disorders

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

(2018) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis

(2018) Tanuja Chitnis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry

(2018) Allan MacKenzie-Graham et al.   Brain and Behavior

Brain activity pattern changes after adaptive working memory training in multiple sclerosis

(2018) Laura Bonzano et al.   Brain Imaging and Behavior

Age-dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross-sectional study

(2018) Andrei Miclea et al.   CNS Neuroscience & Therapeutics

Age is a critical determinant in recovery from multiple sclerosis relapses

(2018) Brittani L Conway et al.   Multiple Sclerosis Journal

Ocrelizumab reduces progression of upper extremity impairment in patients with primary progressive multiple sclerosis: Findings from the phase III randomized ORATORIO trial

(2018) Edward J Fox et al.   Multiple Sclerosis Journal

Body mass index, but not vitamin D status, is associated with brain volume change in MS

(2018) Ellen M. Mowry et al.   NEUROLOGY

Puberty onset and pediatric multiple sclerosis activity in boys

(2018) Brenda Young et al.   Multiple Sclerosis and Related Disorders

Genetic variation in the geneLRP2increases relapse risk in multiple sclerosis

(2017) Yuan Zhou et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis

(2017) Saeedeh Azary et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genetic risk factors for pediatric-onset multiple sclerosis

(2017) Milena A Gianfrancesco et al.   Multiple Sclerosis Journal

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

(2017) Juliana Redondo et al.   Multiple Sclerosis Journal

Diet quality is associated with disability and symptom severity in multiple sclerosis

(2017) Kathryn C. Fitzgerald et al.   NEUROLOGY

Ovarian aging is associated with gray matter volume and disability in women with MS

(2017) Jennifer S. Graves et al.   NEUROLOGY

Maternal and Perinatal Exposures Are Associated With Risk for Pediatric-Onset Multiple Sclerosis

(2017) Jennifer S. Graves et al.   PEDIATRICS

Genetic risk factors for pediatric-onset multiple sclerosis

(2017) Milena A Gianfrancesco et al.   Multiple Sclerosis Journal

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

(2017) Juliana Redondo et al.   Multiple Sclerosis Journal

Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial

(2016) Rhonda R Voskuhl et al.   LANCET NEUROLOGY

Genetic predictors of relapse rate in pediatric MS

(2016) Jennifer S Graves et al.   Multiple Sclerosis Journal

Pediatric multiple sclerosis

(2016) Maria Pia Amato et al.   NEUROLOGY

Environmental and genetic factors in pediatric inflammatory demyelinating diseases

(2016) Emmanuelle Waubant et al.   NEUROLOGY

Characteristics of Children and Adolescents With Multiple Sclerosis

(2016) A. L. Belman et al.   PEDIATRICS

Genetic predictors of relapse rate in pediatric MS

(2016) Jennifer S Graves et al.   Multiple Sclerosis Journal

Menarche increases relapse risk in pediatric multiple sclerosis

(2015) Sabeen Lulu et al.   Multiple Sclerosis Journal

Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort

(2015) Riley Bove et al.   Multiple Sclerosis Journal

Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis

(2015) Stephanie A. Grover et al.   NEUROLOGY

Menarche increases relapse risk in pediatric multiple sclerosis

(2015) Sabeen Lulu et al.   Multiple Sclerosis Journal

Exploration of changes in disability after menopause in a longitudinal multiple sclerosis cohort

(2015) Riley Bove et al.   Multiple Sclerosis Journal

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

(2015) Karen Ann Ribbons et al.   PLoS One

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Epstein–Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis

(2014) Michael P Pender et al.   Multiple Sclerosis Journal

Low testosterone is associated with disability in men with multiple sclerosis

(2014) R Bove et al.   Multiple Sclerosis Journal

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Management of lower urinary tract dysfunction in multiple sclerosis: A systematic review and Turkish consensus report

(2013) Bülent Çetinel et al.   NEUROUROLOGY AND URODYNAMICS

Non-Hormonal Treatment Strategies for Vasomotor Symptoms

(2011) Elise Hall et al.   DRUGS

Common viruses associated with lower pediatric multiple sclerosis risk

(2011) E. Waubant et al.   NEUROLOGY

Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?

(2011) Ulrik Dalgas et al.   Therapeutic Advances in Neurological Disorders

Multiple Sclerosis in the Elderly Patient

(2010) Amer Awad et al.   DRUGS & AGING

Cortical lesions in multiple sclerosis

(2010) Massimiliano Calabrese et al.   Nature Reviews Neurology

Increased Relapse Rate in Pediatric-Onset Compared With Adult-Onset Multiple Sclerosis

(2009) Mark P. Gorman et al.   ARCHIVES OF NEUROLOGY