Review
Clinical Neurology
Nastaran Karimi, Helia Ashourizadeh, Boshra Akbarzadeh Pasha, Maryam Haghshomar, Tahmineh Jouzdani, Parnian Shobeiri, Antonio L. Teixeira, Nima Rezaie
Summary: This study found that patients with multiple sclerosis have significantly lower blood levels of BDNF compared to controls, with differences observed in both serum and plasma levels. Disease duration and male proportion are significantly correlated with BDNF levels.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Review
Clinical Neurology
Gen Li, Qiuping You, Xiao Hou, Shiyan Zhang, Liwen Du, Yuanyuan Lv, Laikang Yu
Summary: Through a systematic review and meta-analysis, it was found that exercise has a significant improvement on cognitive function in patients with multiple sclerosis (MS), especially in memory function. It is recommended that MS patients participate in at least three multicomponent training sessions per week, with each session lasting up to 60 minutes, and achieve a weekly exercise goal of 180 minutes. Exercise lasting 8 or 10 weeks has the best improvement on cognitive function. Furthermore, patients with a worse basal MS status or older age have a greater effect on cognitive function.
JOURNAL OF NEUROLOGY
(2023)
Review
Psychology, Multidisciplinary
Chang Sheng Zhang, Liang Cheng, Xiaoan Chen, Yi Wang, Shuguang Wei, Jinxiu Sun
Summary: This study aimed to investigate the effect of exercise intervention on adolescent depression through a meta-analysis of randomized controlled trials. The results showed that exercise intervention had a moderate and sustained positive effect on reducing depression in adolescents.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Biology
Zhiqiang Liang, Zheng Zhang, Shuo Qi, Jinglun Yu, Zhen Wei
Summary: Brain-derived neurotrophic factor (BDNF) plays an important role in brain health, morphology, and function. A single bout of endurance exercise triggers the expression of BDNF in peripheral blood, making it a useful indicator for assessing the impact of exercise on brain health. Our study investigated the effects of a single bout of endurance exercise on BDNF in humans and analyzed its impact on peripheral BDNF levels in different age groups. The results showed that endurance exercise had a moderate effect on BDNF expression. Serum BDNF was found to be a sensitive factor for evaluating the effects of exercise, regardless of age.
Review
Clinical Neurology
Larissa L. da Cunha, Natan Feter, Ricardo Alt, Airton J. Rombaldi
Summary: This study reviewed the chronic effect of exercise on blood biomarkers and its association with changes in depressive symptoms. The results showed that exercise training can increase circulating BDNF and kynurenine levels, and decrease depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Behavioral Sciences
Kareen Heinze, Jennifer Cumming, Amrita Dosanjh, Sophia Palin, Shannen Poulton, Andrew P. Bagshaw, Matthew R. Broome
Summary: The study aimed to investigate the potential neurobiological mechanisms linking longer-term physical activity interventions to mental health and cognitive outcomes in children, adolescents, and young adults. Results showed that most studies reported improvements in mental health and cognition outcomes following longer-term physical activity interventions, which were associated with neurobiological alterations. Future research should consider measures of pre-existing fitness levels and target individuals who would benefit the most from such interventions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Bo Ning, Teng Ge, Yongqing Wu, Yuting Wang, Mingjun Zhao
Summary: This article reviews the correlation between brain-derived neurotrophic factor (BDNF) and anxiety or depression after percutaneous coronary intervention (PCI), and focuses on the latest research progress of the mechanism of BDNF in anxiety or depression after PCI. It includes the specific mechanisms by which BDNF regulates the levels of inflammatory factors, reduces oxidative stress damage, and mediates multiple signaling pathways. Additionally, this review summarizes the therapeutic potential of BDNF as a potential biomarker for anxiety or depression after PCI.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sahar Foshati, Masoumeh Akhlaghi, Siavash Babajafari
Summary: Interest in supplementation with pro-/synbiotics for brain and mental health is growing. Animal studies have shown that pro-/synbiotic administration can increase levels of brain-derived neurotrophic factor (BDNF), a key regulator of neuronal function. However, human studies have produced inconsistent and conflicting results. In this systematic review and meta-analysis of randomized controlled trials (RCTs), it was found that pro-/synbiotic supplementation significantly increased BDNF concentrations compared to placebo. Subgroup analysis suggested that factors such as target population, ethnicity, age, probiotic strains, administration form, and duration of supplementation were potential sources of heterogeneity between RCTs.
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Review
Clinical Neurology
Davy Vancampfort, Carlos Pelayo Ramos Sanchez, Mats Hallgren, Felipe Schuch, Joseph Firth, Simon Rosenbaum, Tine Van Damme, Brendon Stubbs
Summary: Exercise is well tolerated by individuals with anxiety and stress-related disorders, and dropout rates in randomized controlled trials are comparable to control conditions. When exercise interventions are supervised by fitness experts and autonomous motivation strategies are applied, dropout rates are lower.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Anna Maria Szota, Beata Kowalewska, Malgorzata Cwiklinska-Jurkowska, Wiktor Drozdz
Summary: The main aim of this systematic review and meta-analysis is to investigate the correlation between the level of brain-derived neurotrophic factor (BDNF) and electroconvulsive therapy (ECT) treatment in patients with schizophrenia. The findings showed a statistically significant increase in BDNF levels after ECT treatment in two studies, but not in four other studies.This meta-analysis suggests that ECT therapy and antipsychotic medication may increase serum BDNF levels in patients with drug-resistant schizophrenia, although the effect is not statistically significant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Behavioral Sciences
David Ruiz-Gonzalez, Alba Hernandez-Martinez, Pedro L. Valenzuela, Javier S. Morales, Alberto Soriano-Maldonado
Summary: Exercise interventions significantly increase plasma BDNF levels in individuals with neurodegenerative disorders, with particularly notable effects in multiple sclerosis and Parkinson's disease; irrespective of exercise type, weekly exercise volume, and intervention length, BDNF levels showed significant increases.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Medicine, Research & Experimental
Helia Mojtabavi, Zoha Shaka, Sara Momtazmanesh, Atra Ajdari, Nima Rezaei
Summary: The study confirms that stroke significantly decreases BDNF levels, affecting cognition, affect, and motor function. Patients with depression have lower BDNF levels. Physical training has a short-term positive effect on BDNF levels, while the long-term effects are unclear. Repeated transcranial magnetic stimulation has no effect on BDNF levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Virology
Amene Saghazadeh, Nima Rezaei
Summary: An immunocompromised status increases the risk of monkeypox virus infection and severe disease, highlighting the importance of immune competence for controlling and clearing the virus. Studies have shown various effects of monkeypox virus on the immune system, including stimulation, modulation, and memory, affecting immune cells and molecules such as natural killer cells, macrophages, neutrophils, lymphocytes, cytokines, interferons, chemokines, and complement.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Geraldine Martorella, Hongyu Miao, Duo Wang, Lindsey Park, Kenneth Mathis, JuYoung Park, Julia Sheffler, Lisa Granville, Antonio L. Teixeira, Paul E. Schulz, Hyochol Ahn
Summary: This pilot study aimed to assess the feasibility, acceptability, and preliminary efficacy of transcranial direct current stimulation (tDCS) on chronic pain in older adults with Alzheimer's disease and related dementias (ADRD). The study found that after 5 sessions of 20-minute home-based tDCS, patients in the active tDCS group experienced significant reductions in pain intensity, suggesting that tDCS is a feasible and acceptable intervention for pain in ADRD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Arash Kamali, Sofia Milosavljevic, Anusha Gandhi, Kinsey R. Lano, Parnian Shobeiri, Farzaneh Ghazi Sherbaf, Haris I. Sair, Roy F. Riascos, Khader M. Hasan
Summary: The Papez circuit, proposed in 1937, is believed to control memory and emotions, consisting of several brain regions such as the cingulate cortex, hippocampus, hypothalamus, and thalamus. Recent advances in diffusion-weighted tractography techniques have expanded our knowledge of the limbic system, revealing additional connections between the prefrontal/orbitofrontal cortex, septum, amygdalae, and anterior temporal lobes. This review summarizes the anatomy of the limbic system and provides an updated understanding of its circuitry based on published literature.
Article
Hematology
Azalea M. Thomson, Theresa A. McHugh, Assaf P. Oron, Corey Teply, Nikhil Lonberg, Victor M. Vilchis Tella, Lauren B. Wilner, Kia Fuller, Hailey Hagins, Richard Gyan Aboagye, Melka Biratu Aboye, Eman Abu-Gharbieh, Ahmed Abu-Zaid, Isaac Yeboah Addo, Bright Opoku Ahinkorah, Aqeel Ahmad, Saif Aldeen S. AlRyalat, Hubert Amu, Aleksandr Y. Aravkin, Judie Arulappan, Maha Moh'd Wahbi Atout, Ashish D. Badiye, Sara Bagherieh, Maciej Banach, Morteza Banakar, Mainak Bardhan, Amadou Barrow, Deriba Abera Bedane, Isabela M. Bensenor, Akshaya Srikanth Bhagavathula, Pankaj Bhardwaj, Prarthna Bhardwaj, Ajay Nagesh Bhat, Zulfiqar A. Bhutta, Mariah Malak Bilalaga, Jessica Devin Bishai, Saeid Bitaraf, Archith Boloor, Muhammad Hammad Butt, Vijay Kumar Chattu, Dinh-Toi Chu, Omid Dadras, Xiaochen Dai, Bardia Danaei, Anh Kim Dang, Fitsum Wolde Demisse, Meghnath Dhimal, Daniel Diaz, Shirin Djalalinia, Deepa Dongarwar, Muhammed Elhadi, Mohamed A. Elmonem, Christopher Imokhuede Esezobor, Farshid Etaee, Oghenowede Eyawo, Adeniyi Francis Fagbamigbe, Ali Fatehizadeh, Lisa M. Force, William M. Gardner, Kazem Ghaffari, Paramjit Singh Gill, Mahaveer Golechha, Pouya Goleij, Vivek Kumar Gupta, Hamidreza Hasani, Treska S. Hassan, Mohammed Bheser Hassen, Segun Emmanuel Ibitoye, Adalia I. Ikiroma, Chidozie C. D. Iwu, Peter Bai James, Shubha Jayaram, Rime Jebai, Ravi Prakash Jha, Nitin Joseph, Farnaz Kalantar, Himal Kandel, Ibraheem M. Karaye, Woldeteklehaymanot Dagne Kassahun, Imteyaz A. Khan, Shaghayegh Khanmohammadi, Adnan Kisa, Farzad Kompani, Kewal Krishan, Ivan Landires, Stephen S. Lim, Preetam Bhalchandra Mahajan, Soleiman Mahjoub, Azeem Majeed, Bishnu P. Marasini, Haftu Asmerom Meresa, Tomislav Mestrovic, Sonica Minhas, Awoke Misganaw, Ali H. Mokdad, Lorenzo Monasta, Ghulam Mustafa, Tapas Sadasivan Nair, Sreenivas Narasimha Swamy, Hasan Nassereldine, Zuhair S. Natto, Muhammad Naveed, Biswa Prakash Nayak, Jean Jacques Noubiap, Taylor Noyes, Chisom Adaobi Nri-ezedi, Vincent Ebuka Nwatah, Chimezie Igwegbe Nzoputam, Ogochukwu Janet Nzoputam, Osaretin Christabel Okonji, Adeyinka Omoniyi Onikan, Mayowa O. Owolabi, Jay Patel, Siddhartha Pati, Shrikant Pawar, Ionela-Roxana Petcu, Frederic B. Piel, Ibrahim Qattea, Mehran Rahimi, Mosiur Rahman, Salman Rawaf, Elrashdy Moustafa Mohamed Redwan, Nazila Rezaei, Basema Saddik, Umar Saeed, Fatemeh Saheb Sharif-Askari, Abdallah M. Samy, Austin E. Schumacher, Elaheh Shaker, Adithi Shetty, Migbar Mekonnen Sibhat, Jasvinder A. Singh, Muhammad Suleman, Dev Ram Sunuwar, Mindy D. Szeto, Jacques J. L. Lukenze Tamuzi, Nathan Y. Tat, Birhan Tsegaw Taye, Mohamad-Hani Temsah, Muhammad Umair, Sahel Valadan Tahbaz, Cong Wang, Nuwan Darshana Wickramasinghe, Arzu Yigit, Vahit Yigit, Ismaeel Yunusa, Burhan Abdullah Zaman, Moein Zangiabadian, Peng Zheng, Simon Hay, Mohsen Naghavi, Christopher J. L. Murray, Nicholas J. Kassebaum
Summary: This study provides a comprehensive global assessment of the prevalence and mortality burden of sickle cell disease. It reveals a strikingly high contribution of sickle cell disease to overall mortality, especially in children. Comprehensive strategies are needed to address the morbidity and mortality associated with sickle cell disease.
LANCET HAEMATOLOGY
(2023)
Review
Immunology
Soren Nooraei, Alireza Sarkar Lotfabadi, Milad Akbarzadehmoallemkolaei, Nima Rezaei
Summary: Vaccination is the most effective method for preventing and reducing the impact of infectious diseases in animals and humans. Adjuvants are substances that enhance the immune response and can improve the body's immune reactions. Nanoparticles have shown promise as more effective adjuvants due to their ability to target antigen-presenting cells and easily cross biological barriers.
Article
Neurosciences
Karina Braga Gomes, Ramon Goncalves Pereira, Alexandre Alberto Braga, Henrique Cerqueira Guimaraes, Elisa de Paula Franca Resende, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Wagner Meira Junior, Maria das Gracas Carvalho, Paulo Caramelli
Summary: This study used machine learning algorithms to assess the ability of routine laboratory variables in predicting cognitive and functional decline in older adults. The random forest model was found to be the most accurate in predicting cognitive decline, including variables such as triglycerides, glucose, and hemoglobin. For functional decline, platelet count, hemoglobin, and cortisol were identified as important features. The findings suggest that routine laboratory variables can be used to predict cognitive and functional decline in older populations using machine learning algorithms.
Review
Rheumatology
Parnian Shobeiri, Saba Maleki, Mobina Amanollahi, Amirhossein Habibzadeh, Antonio L. Teixeira, Nima Rezaei
Summary: This study aimed to investigate the blood BDNF levels in patients with SLE. The meta-analysis of 8 studies showed no significant differences in blood BDNF concentrations between SLE patients and healthy controls. Further high-quality studies are needed to explore the potential role and relevance of BDNF in SLE.
ADVANCES IN RHEUMATOLOGY
(2023)
Review
Oncology
Sara Mahdiabadi, Sara Momtazmanesh, Amirali Karimi, Nima Rezaei
Summary: This study conducted a meta-analysis of randomized controlled trials to evaluate the efficacy of immune checkpoint inhibitors (ICIs) for metastatic melanoma. The results showed that ICIs are associated with improved overall survival and can assist clinicians in choosing the optimal treatment approach.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Virology
Hanie Karimi, Vahid Mansouri, Nima Rezaei
Summary: This paper discusses the hypothesis of antibody transmission through the placenta and breast milk following SARS-CoV-2 infection or vaccination, while considering the potential harm and benefits to the fetus/infant.
Article
Public, Environmental & Occupational Health
Seyed Farzad Maroufi, Parnian Shobeiri, Esmaeil Mohammadi, Sina Azadnajafabad, Mohammad-Reza Malekpour, Erfan Ghasemi, Mohammad-Mahdi Rashidi, Sahar Saeedi Moghaddam, Nazila Rezaei, Yeganeh Sharifnejad Tehrani, Sahar Mohammadi Fateh, Naser Ahmadi, Yosef Farzi, Negar Rezaei, Bagher Larijani
Summary: This study evaluated the quality of care given to multiple sclerosis (MS) patients in different regions and countries using the Quality of Care Index (QCI) measure. The study found that countries with higher socioeconomic status had higher QCI, possibly due to better healthcare access and early detection in these regions.
Article
Oncology
Amanda Ramos da Cunha, Kelly Compton, Rixing Xu, Rashmi Mishra, Mark Thomas Drangsholt, Jose Leopoldo Ferreira Antunes, Alexander R. Kerr, Alistair R. Acheson, Dan Lu, Lindsey E. Wallace, Jonathan M. Kocarnik, Weijia Fu, Frances E. Dean, Alyssa Pennini, Hannah Jacqueline Henrikson, Tahiya Alam, Emad Ababneh, Sherief Abd-Elsalam, Meriem Abdoun, Hassan Abidi, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Tigist Demssew Adane, Isaac Yeboah Addo, Aqeel Ahmad, Sajjad Ahmad, Tarik Ahmed Rashid, Maxwell Akonde, Hanadi Al Hamad, Fares Alahdab, Yousef Alimohamadi, Vahid Alipour, Sadeq Ali Al-Maweri, Ubai Alsharif, Alireza Ansari-Moghaddam, Sumadi Lukman Anwar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Aleksandr Y. Aravkin, Raphael Taiwo Aruleba, Malke Asaad, Tahira Ashraf, Seyyed Shamsadin Athari, Sameh Attia, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Muhammad Badar, Nayereh Baghcheghi, Maciej Banach, Mainak Bardhan, Hiba Jawdat Barqawi, Nasir Z. Bashir, Azadeh Bashiri, Habib Benzian, Eduardo Bernabe, Devidas S. Bhagat, Vijayalakshmi S. Bhojaraja, Tone Bjorge, Souad Bouaoud, Dejana Braithwaite, Nikolay Ivanovich Briko, Daniela Calina, Giulia Carreras, Promit Ananyo Chakraborty, Vijay Kumar Chattu, Akhilanand Chaurasia, Meng Xuan Chen, William C. S. Cho, Dinh-Toi Chu, Isaac Sunday Chukwu, Eunice Chung, Natalia Cruz-Martins, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, Reza Darvishi Cheshmeh Soltani, Aso Mohammad Darwesh, Sisay Abebe Debela, Meseret Derbew Molla, Fikadu Nugusu Dessalegn, Mostafa Dianati-Nasab, Lankamo Ena Digesa, Shilpi Gupta Dixit, Abhinav Dixit, Shirin Djalalinia, Iman El Sayed, Maha El Tantawi, Daniel Berhanie Enyew, Daniel Asfaw Erku, Rana Ezzeddini, Adeniyi Francis Fagbamigbe, Luca Falzone, Getahun Fetensa, Takeshi Fukumoto, Piyada Gaewkhiew, Silvano Gallus, Mesfin Gebrehiwot, Ahmad Ghashghaee, Paramjit Singh Gill, Mahaveer Golechha, Pouya Goleij, Ricardo Santiago Gomez, Giuseppe Gorini, Andre Luiz Sena Guimaraes, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Arvin Haj-Mirzaian, Esam S. Halboub, Rabih Halwani, Asif Hanif, Ninuk Hariyani, Mehdi Harorani, Hamidreza Hasani, Abbas M. Hassan, Soheil Hassanipour, Mohammed Bheser Hassen, Simon I. Hay, Khezar Hayat, Brenda Yuliana Herrera-Serna, Ramesh Holla, Nobuyuki Horita, Mehdi Hosseinzadeh, Salman Hussain, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Gaetano Isola, Abhishek Jaiswal, Chinmay T. Jani, Tahereh Javaheri, Umesh Jayarajah, Shubha Jayaram, Nitin Joseph, Vidya Kadashetti, Eswar Kandaswamy, Shama D. Karanth, Ibraheem M. Karaye, Joonas H. Kauppila, Harkiran Kaur, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Javad Khanali, Mahalaqua Nazli Khatib, Hamid Reza Khayat Kashani, Mohammad Amin Khazeei Tabari, Min Seo Kim, Farzad Kompani, Hamid Reza Koohestani, G. Anil Kumar, Om P. Kurmi, Carlo La Vecchia, Dharmesh Kumar Lal, Ivan Landires, Savita Lasrado, Caterina Ledda, Yo Han Lee, Massimo Libra, Stephen S. Lim, Stefan Listl, Platon D. Lopukhov, Ahmad R. Mafi, Rashidul Alam Mahumud, Ahmad Azam Malik, Manu Raj Mathur, Sazan Qadir Maulud, Jitendra Kumar Meena, Entezar Mehrabi Nasab, Tomislav Mestrovic, Reza Mirfakhraie, Awoke Misganaw, Sanjeev Misra, Prasanna Mithra, Yousef Mohammad, Mokhtar Mohammadi, Esmaeil Mohammadi, Ali H. Mokdad, Mohammad Ali Moni, Paula Moraga, Shane Douglas Morrison, Hamid Reza Mozaffari, Sumaira Mubarik, Christopher J. L. Murray, Tapas Sadasivan Nair, Sreenivas Narasimha Swamy, Aparna Ichalangod Narayana, Hasan Nassereldine, Zuhair S. Natto, Biswa Prakash Nayak, Serban Mircea Negru, Haruna Asura Nggada, Hasti Nouraei, Virginia Nunez-Samudio, Bogdan Oancea, Andrew T. Olagunju, Ahmed Omar Bali, Alicia Padron-Monedero, Jagadish Rao Padubidri, Anamika Pandey, Shahina Pardhan, Jay Patel, Raffaele Pezzani, Zahra Zahid Piracha, Navid Rabiee, Venkatraman Radhakrishnan, Raghu Anekal Radhakrishnan, Amir Masoud Rahmani, Vahid Rahmanian, Chythra R. Rao, Sowmya J. Rao, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Nazila Rezaei, Negar Rezaei, Nima Rezaei, Aziz Rezapour, Abanoub Riad, Thomas J. Roberts, Esperanza Romero-Rodriguez, Gholamreza Roshandel, S. Manjula, S. N. Chandan, Basema Saddik, Mohammad Reza Saeb, Umar Saeed, Mohsen Safaei, Maryam Sahebazzamani, Amirhossein Sahebkar, Amir Salek Farrokhi, Abdallah M. Samy, Milena M. Santric-Milicevic, Brijesh Sathian, Maheswar Satpathy, Mario Sekerija, Subramanian Senthilkumaran, Allen Seylani, Omid Shafaat, Hamid R. Shahsavari, Erfan Shamsoddin, Mequannent Melaku Sharew, Javad Sharifi-Rad, Jeevan K. Shetty, K. M. Shivakumar, Parnian Shobeiri, Seyed Afshin Shorofi, Sunil Shrestha, Sudeep K. Siddappa Malleshappa, Paramdeep Singh, Jasvinder A. Singh, Garima Singh, Dhirendra Narain Sinha, Yonatan Solomon, Muhammad Suleman, Rizwan Suliankatchi Abdulkader, Yasaman Taheri Abkenar, Iman M. Talaat, Ker-Kan Tan, Abdelghani Tbakhi, Arulmani Thiyagarajan, Amir Tiyuri, Marcos Roberto Tovani-Palone, Bhaskaran Unnikrishnan, Bay Vo, Simona Ruxandra Volovat, Cong Wang, Ronny Westerman, Nuwan Darshana Wickramasinghe, Hong Xiao, Chuanhua Yu, Deniz Yuce, Ismaeel Yunusa, Vesna Zadnik, Iman Zare, Zhi-Jiang Zhang, Mohammad Zoladl, Lisa M. Force, Fernando N. Hugo
Summary: Lip, oral, and pharyngeal cancers are significant contributors to the global cancer burden. This study analyzed their total and risk-attributable burden across different regions and identified disparities based on Socio-demographic Index (SDI). The findings highlight the substantial impact of tobacco and alcohol use on these types of cancers.
Article
Geriatrics & Gerontology
Natalia P. Rocha, Antonio L. Teixeira, Gabriela D. Colpo, Michelle A. Babicz, Jennifer L. Thompson, Steven Paul Woods
Summary: This study found a significant association between plasma levels of neurofilament light chain (NfL) and HIV-associated neurocognitive disorders (HANDs), suggesting that NfL may serve as a promising biomarker for assessing cognitive function in people living with HIV.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2023)
Review
Neurosciences
Ghazaleh Ghaffaripour Jahromi, Sepideh Razi, Nima Rezaei
Summary: This comprehensive review explores the pathophysiological models of depression and the relationship between NLRP3 inflammasome activation and depression. By adopting the inflammatory theory, the central role of NLRP3 inflammasome activation in depression is explained and supported by evidence from human studies and animal models. The activation of the inflammasome is not limited to the central nervous system, but extends to the gut and peripheral immune systems, affecting the balance of the microbiota-gut-brain axis.
Article
Clinical Neurology
Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibanez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Pina-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suarez, Bernardo Barra, Maria Isabel Behrens, SoniaM. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farias, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nunez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula Franca Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Summary: Limited knowledge on dementia biomarkers in Latin American and Caribbean countries due to lack of funding, infrastructure, and training. However, the region holds great potential to advance dementia biomarkers research and it is crucial to expand research in this field.
ALZHEIMERS & DEMENTIA
(2023)
