Article
Clinical Neurology
Ruth Leadbetter, Michael MacAskill, Daniell J. Myall, Bruce Taylor, Purwa Joshi, Deborah F. Mason
Summary: A long-term study on multiple sclerosis patients in New Zealand found that their median survival age is 7.2 years lower than the general population and they have twice the mortality risk. The survival gap is greater for those with an early age of onset and progressive-onset disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Katharine Elizabeth Harding, Gillian Ingram, Emma Clare Tallantyre, Fady Joseph, Mark Wardle, Trevor P. Pickersgill, Mark D. Willis, Valentina Tomassini, Owen Rhys Pearson, Neil P. Robertson
Summary: This study provides a detailed contemporary model of disability outcomes in a representative population-based MS cohort. The results support a trend of increasing time to disability milestones compared with historical reference populations, and document disability variation with the use of transitional matrices. This study has important implications for patient counseling, clinical trial design, and assessment of therapeutic interventions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Malthe Faurschou Wandall-Holm, Mathias Due Buron, Tine Iskov Kopp, Karsten Thielen, Finn Sellebjerg, Melinda Magyari
Summary: Initiating treatment early reduces the risk of disability pension in patients with RRMS. This finding highlights the importance of early diagnosis and treatment on a patient-centered, socioeconomic disability milestone.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Jeff Rodgers, Tim Friede, Frederick W. Vonberg, Cris S. Constantinescu, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, Helen Ford, Lennora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin McDonnell, Brendan McLean, Owen R. Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Heather C. Wilson, David Ford, Rod M. Middleton, Richard Nicholas
Summary: The negative impact of smoking in multiple sclerosis is well documented, but there is limited evidence on the benefits of smoking cessation for disease progression. This study found that current smokers had higher disability scores compared to those who had never smoked, and there was no improvement in scores with increasing time since quitting. However, when smokers quit, the rate of motor disability deterioration slowed down to match that of non-smokers. This suggests that smoking cessation is beneficial for people with multiple sclerosis.
Review
Clinical Neurology
M. Puthenparampil, P. Perini, R. Bergamaschi, M. Capobianco, M. Filippi, P. Gallo
Summary: Italy is considered a high-risk country for multiple sclerosis (MS), with the incidence and prevalence gradually increasing over the past years. Research suggests that environmental factors may better explain this trend than genetic heterogeneity.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Torbjorn Akerstedt, Tomas Olsson, Lars Alfredsson, Anna Karin Hedstroem
Summary: Insufficient sleep and low sleep quality may increase the risk of developing multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Friederike Neuss, Felix von Podewils, Zhong Irene Wang, Marie Suesse, Uwe Klaus Zettl, Matthias Grothe
Summary: This study described a cohort of patients with both MS and epileptic seizures, finding that a significant percentage of MS patients with seizures had competing causes at the time of the first seizure. A detailed diagnostic setup including patient history, EEG, and MRI is recommended for evaluation and treatment decisions.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Elisa Longinetti, Simon Englund, Joachim Burman, Katharina Fink, Anna Fogdell-Hahn, Martin Gunnarsson, Jan Hillert, Annette Magdalene Langer-Gould, Jan Lycke, Petra Nilsson, Jonatan Salzer, Anders Svenningsson, Johan Mellergard, Tomas Olsson, Fredrik Piehl, Thomas Frisell
Summary: This study analyzed a Swedish nationwide observational study on RRMS to identify trajectories of processing speed and physical disability after DMT start. The results showed that patients' processing speed remained stable over time, while those with moderate physical disability experienced deterioration in physical function. However, there was a strong association between processing speed and disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Niklas Frahm, Melanie Peters, Jorg Baetzing, David Ellenberger, Manas K. Akmatov, Judith Haas, Paulus S. Rommer, Alexander Stahmann, Uwe K. Zettl, Jakob Holstiege
Summary: This study is the largest in terms of both the size of the source population (87% of German children aged <18 years) and the study period (2009-2018) worldwide. The analysis showed an increase in MS prevalence over the past 10 years, with a higher proportion of female patients in the 15-17 age group in 2018.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Matthias Grothe, David Ellenberger, Paulus S. Rommer, Alexander Stahmann, Uwe K. Zettl
Summary: This study analyzed the data of 30,713 multiple sclerosis patients and found that patients with epileptic seizures at onset had a faster disease progression. Among them, patients with polysymptomatic onset had a more severe progression.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Review
Immunology
Ruth Ann Marrie, John D. Fisk, Kathryn Fitzgerald, Kaarina Kowalec, Colleen Maxwell, Dalia Rotstein, Amber Salter, Helen Tremlett
Summary: Comorbid conditions commonly affect people with multiple sclerosis (MS) and have significant impacts on their disease course and outcomes. Studies have shown that people with MS have higher incidence rates of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and psychiatric disorders compared to those without MS. Comorbidities are associated with higher relapse rates, greater physical and cognitive impairments, lower quality of life, and increased mortality among MS patients. Additionally, comorbidity is linked to increased healthcare utilization, costs, and work impairment at the societal level. The management of comorbidities should be integrated into MS care, and optimal care models need to be determined.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Kelsi A. Smith, Fredrik Piehl, Tomas Olsson, Lars Alfredsson, Jan Hillert, Ingrid Kockum, Pernilla Strid, Scott Montgomery
Summary: This study aimed to describe spasticity treatment patterns among people with multiple sclerosis (MS). The results showed that younger patients were more likely to receive baclofen treatment and had high discontinuation rates. This highlights the need for more tolerable and effective spasticity treatments and monitoring of spasticity among people with MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Melinda Magyari, Nils Koch-Henriksen
Summary: There are sex differences in the activity and severity of multiple sclerosis, with women experiencing more inflammatory disease activity and men being more susceptible to the neurodegenerative component.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Soonwook Kwon, Se Young Jung, Kyung-do Han, Jin Hyung Jung, Yohwan Yeo, Eun Bin Cho, Jong Hyeon Ahn, Dong Wook Shin, Ju-Hong Min
Summary: This study found that patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have an increased risk of developing Parkinson's disease (PD), especially in MS patients. Sex, age, diabetes, hypertension, and dyslipidemia did not significantly affect the risk of PD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Gauruv Bose, Brian C. Healy, Christian Barro, Bonnie Glanz, Hrishikesh A. Lokhande, Mariann Polgar-Turcsanyi, Charles R. G. Guttmann, Rohit Bakshi, Howard L. Weiner, Tanuja Chitnis
Summary: For patients with multiple sclerosis (MS) who have a disease duration of more than 10 years, an earlier age at onset is associated with worse outcomes at age 50, including higher disability, increased risk of secondary-progressive MS, more brain lesions, worse brain parenchymal fraction, and higher likelihood of unemployment due to MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Letter
Clinical Neurology
Ruth Ann Marrie, John D. Fisk, Randy Walld, James M. Bolton, Jitender Sareen, Scott B. Patten, Alexander Singer, Lisa M. Lix, Carol A. Hitchon, Renee El-Gabalawy, Alan Katz, James J. Marriott, Charles N. Bernstein
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Floriane Calocer, Huah Shin Ng, Feng Zhu, Yinshan Zhao, Olivier Dejardin, Emmanuelle Leray, Gilles Defer, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett
Summary: The study found that lower socioeconomic status is associated with a higher mortality risk in persons with multiple sclerosis (PwMS).
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Endocrinology & Metabolism
Wajd Alkabbani, Colleen J. Maxwell, Ruth Ann Marrie, Suzanne L. Tyas, Iliana C. Lega, John-Michael Gamble
Summary: This study reveals that both mid- and late-life hypoglycemia are associated with a doubled risk of dementia. Patients who experienced severe hypoglycemic events in mid- and late-life have a higher risk of developing dementia compared to those without hypoglycemia.
Article
Clinical Neurology
Julia O'Mahony, Brenda Banwell, Audrey Laporte, Adalsteinn Brown, Lady Bolongaita, Amit Bar-Or, E. Ann Yeh, Ruth Ann Marrie
Summary: Understanding the factors that influence the relationship between a child's MS diagnosis and parental HRQoL can help improve interventions for both parents and children with MS. The study found that the combination of a child's MS diagnosis with a family health condition or low SEP has a synergistic effect on parental HRQoL. Parents of children with MS who also have other family health conditions or a low SEP are at higher risk for low HRQoL.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Endocrinology & Metabolism
Wajd Alkabbani, Colleen J. J. Maxwell, Ruth Ann Marrie, Suzanne L. L. Tyas, Iliana C. C. Lega, John-Michael Gamble
Summary: This study reevaluates the association between insulin use and dementia risk in type 2 diabetes patients, considering confounding factors. The results showed no significant association between insulin use and all-cause dementia in patients previously treated with two noninsulin antihyperglycemic medications.
Article
Gastroenterology & Hepatology
Ruth Ann Marrie, John D. Fisk, Casandra Dolovich, Lisa M. Lix, Lesley A. Graff, Scott B. Patten, Charles N. Bernstein
Summary: This study compared the psychometric properties of multiple fatigue scales in individuals with inflammatory bowel disease (IBD). The Fatigue Impact Scale (FIS), Modified Fatigue Impact Scale-IBD (MFIS-IBD), and Daily Fatigue Impact Scale (DFIS) showed adequate validity and reliability for assessing fatigue in IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Clinical Neurology
Alyssa N. Nylander, Jessica Singh, Shane Poole, Annika Anderson, Ruth Ann Marrie, Hope Rugo, Riley Bove
Summary: In this study, a case series of multiple sclerosis (MS) patients diagnosed with breast cancer was analyzed retrospectively to understand the clinical characteristics and treatment strategies. The study found that the relapse rate of MS during breast cancer treatment was low, and the neurologic function scores of the patients remained stable. This study provides valuable information for understanding the clinical management of patients with concurrent MS and breast cancer.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Colm Elliott, David A. Rudko, Douglas L. Arnold, Dumitru Fetco, Ahmed M. Elkady, David Araujo, Bing Zhu, Arie Gafson, Zhe Tian, Shibeshih Belachew, Daniel P. Bradley, Elizabeth Fisher
Summary: This study aimed to assess the lesion-level concordance between paramagnetic rim lesions (PRLs) and slowly expanding lesions (SELs) in chronic active lesions (CALs) of multiple sclerosis (MS), and to characterize changes in brain tissue integrity in CALs. The results showed that co-localization of PRLs and SELs was associated with rapid expansion and worsening of microstructural damage over time, and both SELs with and without co-localization with PRLs showed ongoing tissue damage. Therefore, the coexistence of PRLs and SELs is associated with severe accumulation of tissue damage.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Medicine, General & Internal
Carol A. Hitchon, Christine Mesa, Charles N. Bernstein, Ruth Ann Marrie, Catherine Card, Sheila F. O'Brien, John Kim
Summary: This study compared antibody responses and disease activity/states in individuals with immune-mediated inflammatory diseases (IMIDs) who received SARS-CoV-2 vaccines. The results showed that heterologous vaccination improved seroconversion rates and did not lead to disease flare. Therefore, IMID patients benefit from receiving at least three doses of the vaccine.
Article
Medicine, General & Internal
Shaza Almweisheer, Charles N. Bernstein, Lesley A. Graff, Scott B. Patten, James Bolton, John D. Fisk, Carol A. Hitchon, James J. Marriott, Ruth Ann Marrie
Summary: This study aimed to assess the mental health of individuals with immune-mediated inflammatory diseases (IMID) and compare the differences across different types of diseases. The study found that over half of the participants with multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) reported flourishing mental health, with similar levels across the disease groups.
Article
Clinical Neurology
Amber Salter, Alexander Keenan, Hoa H. Le, Kavita Gandhi, Maria Ait-Tihyaty, Samantha Lancia, Gary R. Cutter, Robert J. Fox, Ruth Ann Marrie
Summary: Fatigue is commonly experienced by multiple sclerosis patients, with a majority reporting worsening of fatigue over time. Factors associated with fatigue worsening include lower income, higher disability, lower initial fatigue level, use of injectable disease-modifying therapies, and increased levels of depression.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Clinical Neurology
Elisa Colato, Ferran Prados, Jonathan Stutters, Alessia Bianchi, Sridar Narayanan, Douglas L. Arnold, Claudia Wheeler-Kingshott, Frederik Barkhof, Olga Ciccarelli, Declan T. Chard, Arman Eshaghi
Summary: Network-based measures of white and grey matter damage can predict disability progression and cognitive worsening in multiple sclerosis (MS). This study has important implications for identifying patients at risk of disease worsening and for stratifying cohorts in treatment trials.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Fardowsa L. A. Yusuf, Ayesha Asaf, Ruth Ann Marrie, Ping Li, Kyla McKay, Yinshan Zhao, Feng Zhu, Colleen Maxwell, Helen Tremlett
Summary: Canada has one of the highest rates of paediatric-onset multiple sclerosis (PoMS) globally, and the prevalence, but not incidence, has increased over time. Allocation of resources to support the growing youth population with MS should be a priority.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Dhruv Jain, Charles N. Bernstein, Lesley A. Graff, Scott B. Patten, James M. Bolton, John D. Fisk, Carol Hitchon, James J. Marriott, Ruth Ann Marrie
Summary: This study compared the prevalence of pain and the association between pain and pain interference, as well as social participation, in different subtypes of multiple sclerosis. The results showed that pain was common among all participants, with no differences between subtypes. However, individuals with progressive multiple sclerosis reported higher pain interference and lower social participation compared to those with relapsing-remitting multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Letter
Endocrinology & Metabolism
Wajd Alkabbani, Colleen J. Maxwell, Ruth Ann Marrie, Suzanne L. Tyas, Iliana C. Lega, John-Michael Gamble
DIABETES OBESITY & METABOLISM
(2023)
