Article
Sport Sciences
Hege Wilson Landgraff, Amund Riiser, Maren Lihagen, Marius Skei, Svein Leirstein, Jostein Hallen
Summary: The study investigated the effects of high-volume endurance training on maximal oxygen uptake in physically active 12-15 year old boys and girls, finding that in growing active children during puberty, high volumes of systematic endurance training did not have an additional effect on VO2max compared with similar volume of training mainly aiming at developing motor skills.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Public, Environmental & Occupational Health
Zhonghai Zhu, Christopher R. Sudfeld, Yue Cheng, Qi Qi, Shaoru Li, Mohamed Elhoumed, Wenfang Yang, Suying Chang, Michael J. Dibley, Lingxia Zeng, Wafaie W. Fawzi
Summary: This study found that anemia is present among adolescents in rural western China, with factors such as gender, maternal education level, household wealth, puberty status, and dietary habits being associated with anemia risk. The results indicate the need for interventions targeting these determinants to reduce anemia prevalence in this population.
Review
Biochemistry & Molecular Biology
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Oana Aurelia Vladacenco, Eugenia Roza, Radu-Stefan Perjoc, Daniel Mihai Teleanu
Summary: Multiple sclerosis (MS) is a chronic immune-mediated neurodegenerative disease of the central nervous system, which usually begins around the age of 20-30. However, in recent years, MS has been increasingly recognized among children, with distinct characteristics compared to adult-onset disease. The etiology and mechanisms of the disease are not well understood, leading to uncertain efficacy and safety of MS treatment options in pediatric patients. This review aims to provide insight into the progress in therapeutic strategies for children and adolescents with MS, discussing etiology, risk factors, comorbidities, diagnosis possibilities, treatment strategies, clinical trials, and emerging alternatives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Raphael Hirtz, Lars Libuda, Anke Hinney, Manuel Focker, Judith Buehlmeier, Paul -Martin Holterhus, Alexandra Kulle, Cordula Kiewert, Ronny Kuhnert, Caroline Cohrdes, Triinu Peters, Johannes Hebebrand, Corinna Grasemann
Summary: This study investigated the relationship between depression severity and pubertal development, as well as gonadal/adrenal hormones in girls with significant depressive symptoms. The findings suggest that age at menarche is important for adolescent depression, and it could be considered a prognostic factor for assessing the risk of depression in adolescents. Efforts should be made to address risk factors that contribute to an earlier age at menarche.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Duriel Hardy, Tanuja Chitnis, Emmanuelle Waubant, Brenda Banwell
Summary: Pediatric-onset multiple sclerosis is a relapsing-remitting neuroinflammatory disease characterized by frequent relapses and high lesion burden on MRI. Current treatment focuses on early initiation of disease-modifying therapies to prevent relapses and slow disability progression. Studying the pediatric MS population allows exploration of early-life exposures that contribute to MS development, including perinatal and environmental risk factors.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Gerhard Binder, Theresa J. Lehrian, Elisa Hoffmann, Gunnar Blumenstock, Abdelkader Rahmaoui, Benjamin Trzaskoma, Thomas Reinehr
Summary: CDGP is a tempo variant often mistaken for GHD, where patients have a faster growth rate compared to those with GHD. Previous model estimations underestimated the height velocity of CDGP patients.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Elfa Jonsdottir-Lewis, Amalia Feld, Ryan Ciarlo, Erica Denhoff, Henry A. Feldman, Yee-Ming Chan
Summary: The decision to treat delayed puberty in children with sex steroids relies on patient, family, and provider preference. A retrospective cohort study found that constitutional delay was the most common cause in children with delayed puberty, with a broad age range observed for pubertal entry in some children who were prepubertal at one or more visits. Discussions with patients and families about management should factor in the possibility of a significant wait period for some children before puberty starts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Elfa Jonsdottir-Lewis, Amalia Feld, Ryan Ciarlo, Erica Denhoff, Henry A. Feldman, Yee-Ming Chan
Summary: The study reviewed medical records of 392 girls and 683 boys evaluated for delayed puberty at a large academic medical center between 2000 and 2015. A subcohort of girls and boys showed a broad age range for entering puberty.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pediatrics
Lauren Martin, Barbara J. McMorris, G. Nic Rider
Summary: This study found that about 1.2% of boys reported trading sex, and these boys were more likely to identify as Black or Indigenous, have a marginalized gender identity or sexual expression, have engaged in sexual intercourse, and have experienced various forms of destabilizing circumstances including homelessness, food insecurity, foster care, and substance treatment. These findings challenge assumptions and stereotypes and open up new avenues for research, intervention, and prevention.
Article
Clinical Neurology
Arlette L. Bruijstens, Sandy Molenaar, Yu Yi M. Wong, Robert Kraaij, Rinze F. Neuteboom
Summary: This study investigated the gut microbiota composition and functional pathways in pediatric-onset multiple sclerosis (MS) patients and found that obese children had lower microbiota diversity and higher abundance of certain microbes and functional pathways.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ermelinda De Meo, Raffaello Bonacchi, Lucia Moiola, Bruno Colombo, Francesca Sangalli, Chiara Zanetta, Maria Pia Amato, Vittorio Martinelli, Maria Assunta Rocca, Massimo Filippi
Summary: This study assessed early predictors of 9-year disability in pediatric patients with multiple sclerosis. Factors such as optic nerve lesions and high-efficacy treatment exposure were found to predict time to first relapse. Changes in disease progression at different time points also influenced long-term disability outcomes.
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Pauline Milles, Gianpaolo De Filippo, Helene Maurey, Thomas Tully, Kumaran Deiva
Summary: This study examined the relationship between childhood BMI and pediatric-onset multiple sclerosis (POMS) occurrence, as well as compared clinical-radiologic-biological characteristics within the MS population. Results showed higher BMI in boys with POMS compared to controls, with boys displaying increased inflammation markers in prepubertal patients. Female patients did not show significant differences in BMI compared to controls, but vitamin D levels were lower in boys with higher BMI. Overweight and obesity were more commonly observed in boys with POMS at diagnosis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Environmental Sciences
Carmen Freire, Francesca Castiello, Maria-Jose Lopez-Espinosa, Andrea Beneito, Aitana Lertxundi, Alba Jimeno-Romero, Martine Vrijheid, Maribel Casas
Summary: Prenatal exposure to certain phthalates is associated with pubertal development, particularly earlier puberty in boys with normal weight and girls with overweight/obesity.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Laura Kariola, Tero Varimo, Hanna Huopio, Sirpa Tenhola, Raimo Voutilainen, Silja Kosola, Jorma Toppari, Harri Sintonen, Paeivi J. Miettinen, Taneli Raivio, Matti Hero
Summary: The study found that satisfaction with the appearance in boys with CDGP was lower than their peers, but improved significantly after treatment for one year, with no clear difference in other HRQoL dimensions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ana Pereira, Alexander S. Busch, Fernanda Solares, Ingrid Baier, Camila Corvalan, Veronica Mericq
Summary: The study found an association between BMI and obesity with pubertal timing and precocious gonadarche in Chilean boys. As children grow, BMI, prevalence of total obesity, and central obesity all increased.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Zahra Ghadimi Korka, Shohreh Noorizadeh Dehkordi, Soheil Mansour Sohani, Marzieh Yassin
Summary: The Trunk Impairment Scale (TIS) in Persian has been found to be a relevant and reliable tool for assessing trunk abnormalities in Persian-speaking people with multiple sclerosis (PWMS).
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Maddalena Sparaco, Elisabetta Maida, Floriana Bile, Renato Vele, Luigi Lavorgna, Giuseppina Miele, Simona Bonavita
Summary: The SDQ was translated into Italian and validated for use in pwMS to detect swallowing disturbances. The 14-item SDQ demonstrated high internal consistency, good accuracy, and reliability in pwMS, making it a readily applicable tool for investigating dysphagia in MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
Leticia Rodrigues Gomes, Benito Pereira Damasceno, Brunno Machado de Campos, Alfredo Damasceno
Summary: This study found that patients with multiple sclerosis (MS) have more frequent work restrictions and impairment in money management and driving abilities compared to controls. Cognitive function, physical disability, and MS lesion burden are strongly associated with work restrictions, and social cognition can influence financial capacity. Cognitive and brain reserve can help retain some of these daily occupations.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Letter
Clinical Neurology
Kaitlin E. Riegler, John Beauvais, Lindsay O. Neto, Elizabeth S. Gromisch
Summary: This study examined the differences in resilience levels among individuals with multiple sclerosis (PwMS) who had sleep disorders, sleep problems, and no sleep disorders/problems. The results showed that PwMS with sleep disorders had significantly lower resilience, with the difference being driven by the support from family and friends. These findings highlight the connection between sleep and resilience in PwMS, emphasizing the importance of social support.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Article
Clinical Neurology
A. Maunula, S. Atula, Sm Laakso, Pj Tienari
Summary: This study aimed to investigate the frequency and risk factors of FTY rebound in a hospital district in Southern Finland. The results showed that 10.5% of patients experienced a rebound, and 28% of patients had relapses of any severity after discontinuing FTY. Younger age at diagnosis, longer exposure to FTY, lower lymphocyte count, and higher neutrophil to lymphocyte ratio after discontinuation were identified as risk factors for a rebound.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)