Article
Clinical Neurology
Ruth Leadbetter, Michael MacAskill, Daniell J. Myall, Bruce Taylor, Purwa Joshi, Deborah F. Mason
Summary: A long-term study on multiple sclerosis patients in New Zealand found that their median survival age is 7.2 years lower than the general population and they have twice the mortality risk. The survival gap is greater for those with an early age of onset and progressive-onset disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Katharine Elizabeth Harding, Gillian Ingram, Emma Clare Tallantyre, Fady Joseph, Mark Wardle, Trevor P. Pickersgill, Mark D. Willis, Valentina Tomassini, Owen Rhys Pearson, Neil P. Robertson
Summary: This study provides a detailed contemporary model of disability outcomes in a representative population-based MS cohort. The results support a trend of increasing time to disability milestones compared with historical reference populations, and document disability variation with the use of transitional matrices. This study has important implications for patient counseling, clinical trial design, and assessment of therapeutic interventions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Xin Lin, Yuanhao Yang, Valery Fuh-Ngwa, Xianyong Yin, Steve Simpson-Yap, Ingrid van der Mei, Simon A. Broadley, Anne-Louise Ponsonby, Kathryn P. Burdon, Bruce Taylor, Yuan Zhou
Summary: This study identifies serine as a potential biomarker for the onset and disability progression of multiple sclerosis (MS) through Mendelian randomisation methods.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Malthe Faurschou Wandall-Holm, Mathias Due Buron, Tine Iskov Kopp, Karsten Thielen, Finn Sellebjerg, Melinda Magyari
Summary: Initiating treatment early reduces the risk of disability pension in patients with RRMS. This finding highlights the importance of early diagnosis and treatment on a patient-centered, socioeconomic disability milestone.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Jeff Rodgers, Tim Friede, Frederick W. Vonberg, Cris S. Constantinescu, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, Helen Ford, Lennora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin McDonnell, Brendan McLean, Owen R. Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Heather C. Wilson, David Ford, Rod M. Middleton, Richard Nicholas
Summary: The negative impact of smoking in multiple sclerosis is well documented, but there is limited evidence on the benefits of smoking cessation for disease progression. This study found that current smokers had higher disability scores compared to those who had never smoked, and there was no improvement in scores with increasing time since quitting. However, when smokers quit, the rate of motor disability deterioration slowed down to match that of non-smokers. This suggests that smoking cessation is beneficial for people with multiple sclerosis.
Article
Biochemistry & Molecular Biology
Adela Gonzalez-Jimenez, Pilar Lopez-Cotarelo, Teresa Agudo-Jimenez, Marisa Martinez-Gines, Jose Manuel Garcia-Dominguez, Elena Urcelay, Laura Espino-Paisan
Summary: The study found that the polymorphism rs7923837 near the HHEX gene is significantly lower in lymphocytes of multiple sclerosis (MS) patients and shows divergent subcellular distributions compared to controls. It also suggests a perturbed reciprocal regulation between HHEX and BCL6 in MS patients. Furthermore, MS carriers of the homozygous mutant genotype exhibited distinct metabolic profiles and increased glycolytic rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
M. Puthenparampil, P. Perini, R. Bergamaschi, M. Capobianco, M. Filippi, P. Gallo
Summary: Italy is considered a high-risk country for multiple sclerosis (MS), with the incidence and prevalence gradually increasing over the past years. Research suggests that environmental factors may better explain this trend than genetic heterogeneity.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Zahra Nasr, Vinicius Andreoli Schoeps, Amin Ziaei, Akash Virupakshaiah, Cameron Adams, T. Charles Casper, Michael Waltz, John Rose, Moses Rodriguez, Jan-Mendelt Tillema, Tanuja Chitnis, Jennifer S. Graves, Leslie Benson, Mary Rensel, Lauren Krupp, Amy T. Waldman, Bianca Weinstock-Guttman, Tim Lotze, Benjamin Greenberg, Gregory Aaen, Soe Mar, Teri Schreiner, Janace Hart, Steve Simpson-Yap, Clementina Mesaros, Lisa F. Barcellos, Emmanuelle Waubant
Summary: Using a case-control study, the researchers estimated the gene-environment interaction between exposure to household chemicals and genotypes for risk of paediatric-onset multiple sclerosis. The study found associations between exposure to insect repellents, weed control products, and plant/tree insect or disease control products and an increased risk of paediatric-onset multiple sclerosis. Additionally, significant interactions were found between weed control products and the NFKB1 SNP GG genotype, as well as between plant or disease control products and absence of the HLA-A*02 genotype.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Torbjorn Akerstedt, Tomas Olsson, Lars Alfredsson, Anna Karin Hedstroem
Summary: Insufficient sleep and low sleep quality may increase the risk of developing multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Arlette L. Bruijstens, Sandy Molenaar, Yu Yi M. Wong, Robert Kraaij, Rinze F. Neuteboom
Summary: This study investigated the gut microbiota composition and functional pathways in pediatric-onset multiple sclerosis (MS) patients and found that obese children had lower microbiota diversity and higher abundance of certain microbes and functional pathways.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Rosario Vasta, Ruth Chia, Bryan J. Traynor, Adriano Chio
Summary: This review discusses the role of genetic and environmental factors in motor neuron degeneration and suggests that gene-environment interactions may contribute to the unknown etiology of ALS. Climate is the underlying basis for multiple environmental factors, and the impact of global temperature increase on gene-environment interactions should be monitored.
Article
Biochemistry & Molecular Biology
Julia Horjus, Tineke van Mourik-Banda, Marco A. P. Heerings, Marina Hakobjan, Ward De Witte, Dorothea J. Heersema, Anne J. Jansen, Eva M. M. Strijbis, Brigit A. de Jong, Astrid E. J. Slettenaar, Esther M. P. E. Zeinstra, Erwin L. J. Hoogervorst, Barbara Franke, Wiebe Kruijer, Peter J. Jongen, Leo J. Visser, Geert Poelmans
Summary: This study identified 12 rare genetic variants associated with multiple sclerosis through whole exome sequencing and co-segregation analysis, highlighting the involvement of various biological processes related to (de-/re-)myelination and auto-immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Huijun Wang, Feifan Xiao, Yanyan Qian, Bingbing Wu, Xinran Dong, Yulan Lu, Guoqiang Cheng, Laishuan Wang, Kai Yan, Lin Yang, Liping Chen, Wenqing Kang, Long Li, Xinnian Pan, Qiufen Wei, Deyi Zhuang, Dongmei Chen, Zhaoqing Yin, Ling Yang, Qi Ni, Renchao Liu, Gang Li, Ping Zhang, Xu Li, Xiaomin Peng, Yao Wang, Huiyao Chen, Xiaojing Ma, Fang Liu, Yun Cao, Guoying Huang, Wenhao Zhou
Summary: This study is the largest cohort study to explore the genetic spectrum of patients with CHD in the NICU in China, and the findings may benefit future work on improving genetic screening and counseling for NICU patients with CHD.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Clinical Neurology
Friederike Neuss, Felix von Podewils, Zhong Irene Wang, Marie Suesse, Uwe Klaus Zettl, Matthias Grothe
Summary: This study described a cohort of patients with both MS and epileptic seizures, finding that a significant percentage of MS patients with seizures had competing causes at the time of the first seizure. A detailed diagnostic setup including patient history, EEG, and MRI is recommended for evaluation and treatment decisions.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Elisa Longinetti, Simon Englund, Joachim Burman, Katharina Fink, Anna Fogdell-Hahn, Martin Gunnarsson, Jan Hillert, Annette Magdalene Langer-Gould, Jan Lycke, Petra Nilsson, Jonatan Salzer, Anders Svenningsson, Johan Mellergard, Tomas Olsson, Fredrik Piehl, Thomas Frisell
Summary: This study analyzed a Swedish nationwide observational study on RRMS to identify trajectories of processing speed and physical disability after DMT start. The results showed that patients' processing speed remained stable over time, while those with moderate physical disability experienced deterioration in physical function. However, there was a strong association between processing speed and disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Jessica Edstorp, Yuxia Wei, Emma Ahlqvist, Lars Alfredsson, Valdemar Grill, Leif Groop, Bahareh Rasouli, Elin P. Sorgjerd, Per M. Thorsby, Tiinamaija Tuomi, Bjorn O. Asvold, Sofia Carlsson
Summary: The study reveals that smoking and snus use are associated with a higher risk of LADA and type 2 diabetes, and smoking acts synergistically with HLA high-risk genotypes in the development of LADA.
Article
Clinical Neurology
Cristina M. Gaudioso, Soe Mar, T. Charles Casper, Rachel Codden, Adam Nguyen, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Carla Francisco, Mark P. Gorman, Manu S. Goyal, Jennifer Graves, Benjamin M. Greenberg, Janace Hart, Lauren Krupp, Timothy Lotze, Sona Narula, Sean J. Pittock, Mary Rensel, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, Yolanda Wheeler, Emmanuelle Waubant, Eoin P. Flanagan
Summary: This study aims to determine the frequency of MOG-IgG and AQP4-IgG in pediatric-onset multiple sclerosis (POMS) patients and healthy controls, evaluate the fulfillment of diagnostic criteria in seropositive cases, compare characteristics and outcomes between POMS and MOGAD, and identify clinical features associated with final diagnosis.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Lauren B. Krupp, Emmanuelle Waubant, Michael Waltz, T. Charles Casper, Anita Belman, Yolanda Wheeler, Jayne Ness, Jennifer Graves, Mark Gorman, Leslie Benson, Soe Mar, Manu Goyal, Teri Schreiner, Bianca Weinstock-Guttman, Moses Rodriguez, Jan-Mendelt Tillema, Timothy Lotze, Greg Aaen, Mary Rensel, John Rose, Tanuja Chitinis, Allan George, Leigh E. Charvet
Summary: The cognitive differences between pediatric and adult multiple sclerosis (MS) are not well understood. This study compared cognitive performances in pediatric MS, adult MS, and pediatric healthy controls, and found that pediatric MS patients perform better than adults with MS on cognitive screens.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Kelsi A. Smith, Fredrik Piehl, Tomas Olsson, Lars Alfredsson, Jan Hillert, Ingrid Kockum, Pernilla Strid, Scott Montgomery
Summary: This study aimed to describe spasticity treatment patterns among people with multiple sclerosis (MS). The results showed that younger patients were more likely to receive baclofen treatment and had high discontinuation rates. This highlights the need for more tolerable and effective spasticity treatments and monitoring of spasticity among people with MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Ibrahim Abdollahpour, Yahya Salimi, Saharnaz Nedjat, Maryam Nazemipour, Mohammad Ali Mansournia, Bianca Weinstock-Guttman
Summary: The study found that there is an additive interaction between Dietary Inflammatory Index (DII) and drug abuse, gender, and history of depression in multiple sclerosis (MS). However, there is no evidence of multiplicative interaction between DII and other risk factors of MS.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Chiara Starvaggi Cucuzza, Elisa Longinetti, Nicolas Ruffin, Bjoern Evertsson, Ingrid Kockum, Maja Jagodic, Faiez Al Nimer, Thomas Frisell, Fredrik Piehl
Summary: This study aimed to determine the clinical and neuroradiologic disease activity, as well as B-cell repopulation dynamics, after implementing extended rituximab dosing in RRMS. The results showed that extended dosing intervals did not increase the risk of relapse in RRMS, and the dynamics of total B-cell and memory B-cell repopulation varied considerably.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Immunology
Dejan Jakimovski, Svetlana P. Eckert, Omid Mirmosayyeb, Sangharsha Thapa, Penny Pennington, David Hojnacki, Bianca Weinstock-Guttman
Summary: This study aimed to determine the real-world efficacy of tixagevimab and cilgavimab (Evusheld (TM)) in preventing breakthrough COVID-19 infections in immunosuppressed persons with neuroinflammatory diseases (pwNID). The results showed that pwNID treated with tixagevimab and cilgavimab had a significantly lower rate of COVID-19 infections and milder severity compared to the control group.
Article
Medicine, General & Internal
Nicholas Young, Robert Zivadinov, Michael G. Dwyer, Niels Bergsland, Bianca Weinstock-Guttman, Dejan Jakimovski
Summary: This study found that people with multiple sclerosis (pwMS) have fewer retinal blood vessels compared to healthy controls (HCs). Over time, pwMS experience a decrease in retinal vessel number while HCs experience an increase. Furthermore, there is a correlation between lower RNFL thickness and fewer retinal vessel number and smaller diameter in pwMS.
Article
Clinical Neurology
Mary K. Horton, Joan E. Shim, Amelia Wallace, Jennifer S. Graves, Gregory Aaen, Benjamin Greenberg, Soe Mar, Yolanda Wheeler, Bianca Weinstock-Guttman, Amy Waldman, Teri Schreiner, Moses Rodriguez, Jan-Mendelt Tillema, Tanuja Chitnis, Lauren Krupp, T. Charles Casper, Mary Rensel, Janace Hart, Hong L. Quach, Diana L. Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F. Barcellos
Summary: Rare genetic variants play an important role in pediatric-onset multiple sclerosis (POMS). Specifically, genes associated with adult-onset MS risk (PRF1, PRKRA, NLRP8, and HDAC7) and 52 major histocompatibility complex (MHC) genes are also associated with POMS. These findings highlight the benefits of investigating rare genetic variation in complex diseases.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Caila B. Vaughn, Katelyn S. Kavak, Dejan Jakimovski, Natasha Qutab, Robin Avila, Megan Vignos, Bianca Weinstock-Guttman
Summary: A large retrospective study found that patient-reported limitations in physical and mental symptoms can predict future disability worsening in multiple sclerosis (MS) patients treated with intramuscular interferon-beta medication. The study also identified lower extremities limitations and fatigue as the most predictive factors for disability worsening.
NEURODEGENERATIVE DISEASE MANAGEMENT
(2023)
Article
Clinical Neurology
Marianne Hahn, Eyad Hayani, Lynn Bitar, Sonja Groeschel, Falk Steffen, Maria Protopapa, Ahmed Othman, Stefan Bittner, Frauke Zipp, Klaus Groeschel, Timo Uphaus
Summary: This study investigates the association between strict achievement of a blood pressure target of <= 160/90 mmHg and the extent of neuronal loss and functional outcome. The results suggest that strict blood pressure control may lead to increased neuronal injury and poor functional outcome, potentially indicating hypotension-induced neuronal loss during the post-MT phase.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Dejan Jakimovski, Taylor R. Wicks, Niels Bergsland, Michael G. Dwyer, Bianca Weinstock-Guttman, Robert Zivadinov
Summary: This study found that patient-reported outcomes (PROs) are associated with concurrent and future impairments in persons with multiple sclerosis (pwMS). The structural and pathological relationships with PROs in pwMS have not been elucidated.
DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE
(2023)
Article
Clinical Neurology
Daniel Jons, Viktor Grut, Tomas Bergstrom, Henrik Zetterberg, Martin Bistroem, Martin Gunnarsson, Magnus Vrethem, Nicole Brenner, Julia Butt, Kaj Blennow, Staffan Nilsson, Ingrid Kockum, Tomas Olsson, Tim Waterboer, Peter Sundstrom, Oluf Andersen
Summary: The study found that seroreactivity against latent and lytic EBV antigens, as well as ANO2, could be detected around a decade before clinical MS onset, with a gradual increase in axonal injury levels. These findings support the hypothesis of latent EBV involvement in the pathogenesis of MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Meeting Abstract
Clinical Neurology
Catharina C. Gross, Andreas Schulte-Mecklenbeck, Olga V. Steinberg, Timo Wirth, Sarah Lauks, Sergio E. Baranzini, Stefan Bittner, Judith Bellmann-Strobl, Nora Buenger, Eva Eilers, Maria Eveslage, Vinzenz Fleischer, Barbara Gisevius, Sergiu Groppa, Juergen Haas, Martin Kerschensteiner, Lucienne Kirstein, Catharina Korsukewitz, Lisa Lohmann, Jan Luenemann, Felix Luessi, Gerd Meyerzu Hoerste, Jeremias Motte, Tobias Ruck, Nicholas Schwab, Sven G. Meuth, Friedemann Paul, Brigitte Wildemann, Tania Kuempfel, Ralf Gold, Frauke Zipp, Luisa Klotz, Heinz Wiendl
