Systemic sclerosis interstitial lung disease: unmet needs and potential solutions

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

(2023) Christina Bergmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Recent innovations in the screening and diagnosis of systemic sclerosis-associated interstitial lung disease

(2023) Ashima Makol et al.   Expert Review of Clinical Immunology

Effects of Ruxolitinib on fibrosis in preclinical models of systemic sclerosis

(2023) Nessrine Bellamri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Lung Ultrasound in Systemic Sclerosis

(2023) Miguel Gomes Guerra et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Phosphodiesterase 4B inhibition: a potential novel strategy for treating pulmonary fibrosis

(2023) Martin Kolb et al.   European Respiratory Review

Pulmonary Ultrasonography in Systemic Sclerosis-Induced Interstitial Lung Disease—A Systematic Review and Meta-Analysis

(2023) Mislav Radić et al.   Diagnostics

Peripheral blood gene expression profiling shows predictive significance for response to mycophenolate in systemic sclerosis-related interstitial lung disease

(2022) Shervin Assassi et al.   ANNALS OF THE RHEUMATIC DISEASES

Dyspnoea and cough in patients with systemic sclerosis-associated interstitial lung disease in the SENSCIS trial

(2022) Elizabeth R Volkmann et al.   RHEUMATOLOGY

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2022) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Continued treatment with nintedanib in patients with systemic sclerosis-associated interstitial lung disease: data from SENSCIS-ON

(2022) Yannick Allanore et al.   ANNALS OF THE RHEUMATIC DISEASES

Interstitial lung diseases

(2022) Marlies Wijsenbeek et al.   LANCET

The Role of B Cells in Scleroderma Lung Disease Pathogenesis

(2022) Stamatis-Nick C. Liossis et al.   Frontiers in Medicine

Cohort enrichment strategies for progressive interstitial lung disease in systemic sclerosis from EUSTAR

(2022) Anna-Maria Hoffmann-Vold et al.   CHEST

Extent of fibrosis and lung function decline in patients with systemic sclerosis and interstitial lung disease: data from the SENSCIS trial

(2022) Christopher P Denton et al.   RHEUMATOLOGY

Systemic sclerosis-associated interstitial lung disease in the EUSTAR database: analysis by region

(2022) Alain Lescoat et al.   RHEUMATOLOGY

Clinical Predictors of Lung-Function Decline in Systemic-Sclerosis-Associated Interstitial Lung Disease Patients with Normal Spirometry

(2022) Tamas Nagy et al.   Biomedicines

Systemic sclerosis

(2022) Elizabeth R Volkmann et al.   LANCET

Association of symptoms of gastroesophageal reflux, esophageal dilation and progression of systemic sclerosis‐related interstitial lung disease

(2022) Elizabeth R. Volkmann et al.   ARTHRITIS CARE & RESEARCH

Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial

(2022) Toby M Maher et al.   Lancet Respiratory Medicine

Efficacy and safety of rituximab on lung and skin involvement in systemic sclerosis: a systematic review and metaanalysis

(2021) Sasimon Borrirukwisitsak et al.   CLINICAL RHEUMATOLOGY

Targeting human plasmacytoid dendritic cells through BDCA2 prevents skin inflammation and fibrosis in a novel xenotransplant mouse model of scleroderma

(2021) Rebecca L Ross et al.   ANNALS OF THE RHEUMATIC DISEASES

Tocilizumab Prevents Progression of Early Systemic Sclerosis Associated Interstitial Lung Disease

(2021) David Roofeh et al.   Arthritis & Rheumatology

Endothelial‐to‐mesenchymal transition in systemic sclerosis

(2021) P. Di Benedetto et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease

(2021) Eleanor Valenzi et al.   Frontiers in Immunology

Bortezomib Inhibits Lung Fibrosis and Fibroblast Activation Without Proteasome Inhibition

(2021) Loka Raghu Kumar Penke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Association Between Immunosuppressive Therapy and Incident Risk of Interstitial Lung Disease in Systemic Sclerosis

(2021) Sabrina Hoa et al.   CHEST

Disease pathology in fibrotic interstitial lung disease: is it all about usual interstitial pneumonia?

(2021) Elisabetta A Renzoni et al.   LANCET

SYSTEMIC SCLEROSIS‐ASSOCIATED INTERSTITIAL LUNG DISEASE: How to incorporate two Food and Drug Administration‐approved therapies in clinical practice

(2021) Dinesh Khanna et al.   Arthritis & Rheumatology

Development and validation of a patient-reported outcome measure for systemic sclerosis: the EULAR Systemic Sclerosis Impact of Disease (ScleroID) questionnaire

(2021) Mike O Becker et al.   ANNALS OF THE RHEUMATIC DISEASES

Lung ultrasound B-lines in systemic sclerosis: cut-off values and methodological indications for interstitial lung disease screening

(2021) Luna Gargani et al.   RHEUMATOLOGY

Screening and management of subclinical interstitial lung disease in systemic sclerosis: an international survey

(2021) Sabrina Hoa et al.   RHEUMATOLOGY

Assessment of interstitial lung disease in systemic sclerosis using the quantitative CT algorithm CALIPER

(2020) Alessandro Maria Ferrazza et al.   CLINICAL RHEUMATOLOGY

Predictors of progression in systemic sclerosis patients with interstitial lung disease

(2020) Oliver Distler et al.   EUROPEAN RESPIRATORY JOURNAL

Systemic sclerosis-associated interstitial lung disease

(2020) Apostolos Perelas et al.   Lancet Respiratory Medicine

Prognostic value of lung ultrasound B-lines in systemic sclerosis

(2020) Luna Gargani et al.   CHEST

Efficacy and safety of pirfenidone in systemic sclerosis-related interstitial lung disease—a randomised controlled trial

(2020) Nupoor Acharya et al.   RHEUMATOLOGY INTERNATIONAL

Generation of a novel CD30 + B cell subset producing GM‐CSF and its possible link to the pathogenesis of systemic sclerosis

(2020) K. Higashioka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The perpetual enigma of bronchoalveolar lavage fluid lymphocytosis in chronic hypersensitivity pneumonitis: is it of diagnostic value?

(2020) Francesco Bonella et al.   EUROPEAN RESPIRATORY JOURNAL

Performance Characteristics of Pulmonary Function Tests for the Detection of Interstitial Lung Disease in Adults with Early Diffuse Cutaneous Systemic Sclerosis

(2020) Elana J. Bernstein et al.   Arthritis & Rheumatology

Bioactive Plasma Mitochondrial DNA is Associated with Disease Progression in Scleroderma Associated Interstitial Lung Disease

(2020) Changwan Ryu et al.   Arthritis & Rheumatology

Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database

(2020) Anna-Maria Hoffmann-Vold et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic sclerosis pathogenesis

(2020) Cindy Orvain et al.   CURRENT OPINION IN RHEUMATOLOGY

Progressive fibrosing interstitial lung disease: clinical uncertainties, consensus recommendations, and research priorities

(2020) Peter M George et al.   Lancet Respiratory Medicine

Automatic Quantification of Interstitial Lung Disease From Chest Computed Tomography in Systemic Sclerosis

(2020) Alysson Roncally S. Carvalho et al.   Frontiers in Medicine

Predictive Significance of Serum Interferon Inducible Protein Score for Response to Treatment in Systemic Sclerosis Related Interstitial Lung Disease

(2020) Shervin Assassi et al.   Arthritis & Rheumatology

Ethnic Variations in Systemic Sclerosis Disease Manifestations, Internal Organ Involvement, and Mortality

(2019) Haifa Al-Sheikh et al.   JOURNAL OF RHEUMATOLOGY

Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort

(2019) Wanlong Wu et al.   ANNALS OF THE RHEUMATIC DISEASES

Management of systemic sclerosis-associated interstitial lung disease

(2019) David Roofeh et al.   CURRENT OPINION IN RHEUMATOLOGY

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

(2019) Oliver Distler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets

(2019) Paula S. Ramos et al.   Clinical Epigenetics

Tracking Impact of Interstitial Lung Disease in Systemic Sclerosis in a Complete Nationwide Cohort

(2019) Anna-Maria Hoffmann-Vold et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ultrasound in the assessment of interstitial lung disease in systemic sclerosis. A systematic literature review by the OMERACT Ultrasound Group

(2019) Marwin Gutierrez et al.   JOURNAL OF RHEUMATOLOGY

Association between immunosuppressive therapy and course of mild interstitial lung disease in systemic sclerosis

(2019) Sabrina Hoa et al.   RHEUMATOLOGY

Detection and classification of systemic sclerosis-related interstitial lung disease

(2019) Daniel J. DeMizio et al.   CURRENT OPINION IN RHEUMATOLOGY

The quantitative assessment of interstitial lung disease with positron emission tomography scanning in systemic sclerosis patients

(2019) Daphne M Peelen et al.   RHEUMATOLOGY

Using autoantibodies and cutaneous subset to develop outcome‐based disease classification in systemic sclerosis

(2019) Svetlana I. Nihtyanova et al.   Arthritis & Rheumatology

Elevated level of Galectin-1 in bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis

(2019) David Bennett et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Prediction of progression of interstitial lung disease in patients with systemic sclerosis: the SPAR model

(2018) Wanlong Wu et al.   ANNALS OF THE RHEUMATIC DISEASES

Lung Ultrasound as a Screening Method for Interstitial Lung Disease in Patients With Systemic Sclerosis

(2018) Romina Isabel Hassan et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma

(2018) Keith M. Sullivan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Screening High-Resolution Computed Tomography of the Chest to Detect Interstitial Lung Disease in Systemic Sclerosis: A Global Survey of Rheumatologists

(2018) Elana J. Bernstein et al.   Arthritis & Rheumatology

Major lung complications of systemic sclerosis

(2018) Christopher P. Denton et al.   Nature Reviews Rheumatology

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis

(2018) Roberto Giacomelli et al.   AUTOIMMUNITY REVIEWS

Interstitial lung disease in systemic sclerosis: current and future treatment

(2017) Roberto Giacomelli et al.   RHEUMATOLOGY INTERNATIONAL

Innate Immunity in Systemic Sclerosis

(2017) Christopher Dowson et al.   Current Rheumatology Reports

Belimumab for the Treatment of Early Diffuse Systemic Sclerosis

(2017) Jessica K. Gordon et al.   Arthritis & Rheumatology

Scleroderma Peripheral B Lymphocytes Secrete Interleukin-6 and Transforming Growth Factor β and Activate Fibroblasts

(2017) Nicolas Dumoitier et al.   Arthritis & Rheumatology

Short-Term Pulmonary Function Trends Are Predictive of Mortality in Interstitial Lung Disease Associated With Systemic Sclerosis

(2017) Nicole S. Goh et al.   Arthritis & Rheumatology

Update of EULAR recommendations for the treatment of systemic sclerosis

(2016) Otylia Kowal-Bielecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Vascular hypothesis revisited: Role of stimulating antibodies against angiotensin and endothelin receptors in the pathogenesis of systemic sclerosis

(2016) Otavio Cabral-Marques et al.   AUTOIMMUNITY REVIEWS

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial

(2016) Donald P Tashkin et al.   Lancet Respiratory Medicine

Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1

(2016) Peter J. Wermuth et al.   PLoS One

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

(2015) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Lung ultrasound in systemic sclerosis: correlation with high-resolution computed tomography, pulmonary function tests and clinical variables of disease

(2015) Antonietta Gigante et al.   Internal and Emergency Medicine

Connective Tissue Disease-associated Interstitial Lung Diseases (CTD-ILD) -- Report from OMERACT CTD-ILD Working Group

(2015) D. Khanna et al.   JOURNAL OF RHEUMATOLOGY

Changes in forced vital capacity over time in systemic sclerosis: application of group-based trajectory modelling

(2015) Ada Man et al.   RHEUMATOLOGY

Screening for interstitial lung disease in systemic sclerosis: performance of high-resolution CT with limited number of slices: a prospective study

(2014) Thomas Frauenfelder et al.   ANNALS OF THE RHEUMATIC DISEASES

Predictors of Mortality and Progression in Scleroderma-Associated Interstitial Lung Disease

(2014) Tiffany A. Winstone et al.   CHEST

Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis

(2014) Jacob M. van Laar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

(2014) Avram Goldberg et al.   ARTHRITIS RESEARCH & THERAPY

2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative

(2013) Frank van den Hoogen et al.   ARTHRITIS AND RHEUMATISM

Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

(2013) Lenny van Bon et al.   NEW ENGLAND JOURNAL OF MEDICINE

B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis

(2013) Antoine François et al.   ARTHRITIS RESEARCH & THERAPY

Lung ultrasound for the screening of interstitial lung disease in very early systemic sclerosis

(2012) Tatiana Barskova et al.   ANNALS OF THE RHEUMATIC DISEASES

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomised phase 2 trial

(2011) Richard K Burt et al.   LANCET

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1signalling

(2011) Gökhan M Mutlu et al.   THORAX

Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction

(2010) Dmitri V. Pechkovsky et al.   CLINICAL IMMUNOLOGY

Increased epithelial permeability in pulmonary fibrosis in relation to disease progression

(2010) N. S. L. Goh et al.   EUROPEAN RESPIRATORY JOURNAL

Coagulation and Autoimmunity in Scleroderma Interstitial Lung Disease

(2010) Anna Ludwicka-Bradley et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort

(2010) Shervin Assassi et al.   ARTHRITIS RESEARCH & THERAPY

Interstitial Lung Disease in Systemic Sclerosis

(2008) Nicole S. L. Goh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE