Targeting human plasmacytoid dendritic cells through BDCA2 prevents skin inflammation and fibrosis in a novel xenotransplant mouse model of scleroderma

Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site

(2020) Steven R. Bryden et al.   Science Translational Medicine

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus

(2019) Richard Furie et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

(2019) Roberto Lande et al.   Nature Communications

Role of type I interferons and innate immunity in systemic sclerosis

(2019) Franck J. Barrat et al.   CURRENT OPINION IN RHEUMATOLOGY

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

(2018) Marie Dominique Ah Kioon et al.   Science Translational Medicine

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

(2018) Tom Hartwig et al.   Cell Reports

Dermal white adipose tissue implicated in SSc pathogenesis

(2017) John Varga et al.   Nature Reviews Rheumatology

Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity

(2016) Franck J. Barrat et al.   Annual Review of Medicine

Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner

(2016) J-Y Guo et al.   ONCOGENE

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

(2015) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

(2015) A. Pellerin et al.   EMBO Molecular Medicine

Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology

(2015) Karin Pelka et al.   IMMUNOLOGICAL REVIEWS

Systemic Lupus Erythematosus - A Disease with A Dysregulated Type I Interferon System

(2015) N. Hagberg et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis

(2015) Shervin Assassi et al.   Arthritis & Rheumatology

A Longitudinal Biomarker for the Extent of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis

(2015) Lisa M. Rice et al.   Arthritis & Rheumatology

Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated with Distinct Subsets of Systemic Sclerosis Patients in Three Independent Cohorts

(2015) Michael E. Johnson et al.   PLoS One

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

(2014) Sarah L. Rowland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serglycin: At the Crossroad of Inflammation and Malignancy

(2014) Angeliki Korpetinou et al.   Frontiers in Oncology

Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts

(2013) Diana TA Ploeger et al.   Cell Communication and Signaling

Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

(2013) Lenny van Bon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aldara activates TLR7-independent immune defence

(2013) Anne Walter et al.   Nature Communications

Correlation of interferon-inducible chemokine plasma levels with disease severity in systemic sclerosis

(2012) Xiaochun Liu et al.   ARTHRITIS AND RHEUMATISM

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

(2010) Melissa Swiecki et al.   IMMUNOLOGICAL REVIEWS

The interferon-α signature of systemic lupus erythematosus

(2010) G. Obermoser et al.   LUPUS

Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications

(2008) C. Guiducci et al.   JOURNAL OF INTERNAL MEDICINE

Type I Interferon: Potential Therapeutic Target for Psoriasis?

(2008) Yihong Yao et al.   PLoS One