Local and systemic mechanisms that control the hair follicle stem cell niche

Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice

(2023) Chen Yuan Kam et al.   CELL

Blood endothelial ALK1‐BMP4 signaling axis regulates adult hair follicle stem cell activation

(2023) Kefei Nina Li et al.   EMBO JOURNAL

Dedifferentiation maintains melanocyte stem cells in a dynamic niche

(2023) Qi Sun et al.   NATURE

Metabolic regulation of somatic stem cells in vivo

(2022) Corbin E. Meacham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nerve–stem cell crosstalk in skin regeneration and diseases

(2022) Jingyu Peng et al.   TRENDS IN MOLECULAR MEDICINE

The Effect of the Season, the Maintenance System and the Addition of Polyunsaturated Fatty Acids on Selected Biological and Physicochemical Features of Rabbit Fur

(2022) Katarzyna Roman et al.   Animals

Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche

(2022) Zhi Liu et al.   NATURE IMMUNOLOGY

Ageing and rejuvenation of tissue stem cells and their niches

(2022) Anne Brunet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stress‐associated ectopic differentiation of melanocyte stem cells and ORS amelanotic melanocytes in an ex vivo human hair follicle model

(2021) Inbal Rachmin et al.   EXPERIMENTAL DERMATOLOGY

Factors associated with perceived-stress in patients of the vitiligo ComPaRe e-cohort

(2021) Morgane Condamina et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

(2021) Kefei Nina Li et al.   EMBO JOURNAL

Regulation of tissue regeneration by the circadian clock

(2021) Christina L. Ruby et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

(2021) Sekyu Choi et al.   NATURE

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

(2021) Shamik Mascharak et al.   SCIENCE

The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function

(2021) Anna Geueke et al.   EMBO REPORTS

Obesity accelerates hair thinning by stem cell-centric converging mechanisms

(2021) Hironobu Morinaga et al.   NATURE

Tracing the origin of hair follicle stem cells

(2021) Ritsuko Morita et al.   NATURE

Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility

(2021) Janis Koester et al.   NATURE CELL BIOLOGY

Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

(2021) Yuhua Xie et al.   Cell Stem Cell

Anatomically distinct fibroblast subsets determine skin autoimmune patterns

(2021) Zijian Xu et al.   NATURE

Fur colour in the Arctic fox: genetic architecture and consequences for fitness

(2021) Lukas Tietgen et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells

(2020) Bing Zhang et al.   NATURE

The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year

(2020) Christiane O’Brien et al.   PLoS One

The aging skin microenvironment dictates stem cell behavior

(2020) Yejing Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic regulation of seasonal coat color change in hares

(2020) Mafalda S. Ferreira et al.   Ecology and Evolution

Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells

(2020) Zhiwei Lu et al.   eLife

Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss

(2020) Wisoo Shin et al.   DEVELOPMENTAL CELL

Getting under the skin of hair aging: the impact of the hair follicle environment

(2020) Rachael Williams et al.   EXPERIMENTAL DERMATOLOGY

Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

(2020) Yulia Shwartz et al.   CELL

SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice

(2020) Guo Li et al.   EMBO JOURNAL

Mechanisms of stretch-mediated skin expansion at single-cell resolution

(2020) Mariaceleste Aragona et al.   NATURE

Immune modulation of hair follicle regeneration

(2020) Waleed Rahmani et al.   npj Regenerative Medicine

Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

(2020) Christine S. Kim et al.   Cell Metabolism

The dermal sheath: An emerging component of the hair follicle stem cell niche

(2020) Pieter A. Martino et al.   EXPERIMENTAL DERMATOLOGY

Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock

(2020) Sarina Harshuk-Shabso et al.   Nature Communications

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

An Updated Classification of Hair Follicle Morphogenesis

(2019) Nivedita Saxena et al.   EXPERIMENTAL DERMATOLOGY

A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

(2019) Etienne C.E. Wang et al.   Cell Stem Cell

Circadian Regulation in Tissue Regeneration

(2019) Ellen Paatela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Histopathology of aging of the hair follicle

(2019) Angel Fernandez‐Flores et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

(2019) Juarez Antonio Simões Quaresma   CLINICAL MICROBIOLOGY REVIEWS

Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

(2019) Kefei Nina Li et al.   eLife

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

(2019) Daniel Peña‐Jimenez et al.   EMBO JOURNAL

Architecture of the Cutaneous Autonomic Nervous System

(2019) Patrick Glatte et al.   Frontiers in Neurology

Patch repair of deep wounds by mobilized fascia

(2019) Donovan Correa-Gallegos et al.   NATURE

Stem cell–driven lymphatic remodeling coordinates tissue regeneration

(2019) Shiri Gur-Cohen et al.   SCIENCE

The Seed Tends to the Soil: Hair Follicle Stem Cells Remodel Their Lymphatic Niche

(2019) Denise Gay et al.   Cell Stem Cell

Dermal sheath contraction powers stem cell niche relocation during hair cycle regression

(2019) Nicholas Heitman et al.   SCIENCE

Fighting against Skin Aging

(2018) Shoubing Zhang et al.   CELL TRANSPLANTATION

Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

(2018) Dongsheng Jiang et al.   NATURE CELL BIOLOGY

External light activates hair follicle stem cells through eyes via an ipRGC–SCN–sympathetic neural pathway

(2018) Sabrina Mai-Yi Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

(2018) Emanuel Rognoni et al.   TRENDS IN CELL BIOLOGY

Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration

(2018) Zhou Yu et al.   Cell Stem Cell

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

(2018) Marion Claudia Salzer et al.   CELL

Hair follicle epidermal stem cells define a niche for tactile sensation

(2018) Chun-Chun Cheng et al.   eLife

Stem cells repurpose proliferation to contain a breach in their niche barrier

(2018) Kenneth Lay et al.   eLife

Hair coat properties of donkeys, mules and horses in a temperate climate

(2017) B. Osthaus et al.   EQUINE VETERINARY JOURNAL

Regulatory T cells in skin

(2017) Niwa Ali et al.   IMMUNOLOGY

Stem cells: Aging and transcriptional fingerprints

(2017) Brice E. Keyes et al.   JOURNAL OF CELL BIOLOGY

Lactate dehydrogenase activity drives hair follicle stem cell activation

(2017) Aimee Flores et al.   NATURE CELL BIOLOGY

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

(2017) Qixuan Wang et al.   eLife

Emerging roles of transit-amplifying cells in tissue regeneration and cancer

(2017) Bing Zhang et al.   Wiley Interdisciplinary Reviews-Developmental Biology

WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation

(2016) Tamara Ouspenskaia et al.   CELL

Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis

(2016) Guillermo C. Rivera-Gonzalez et al.   Cell Stem Cell

Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

(2016) Bing Zhang et al.   GENES & DEVELOPMENT

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

(2016) Alessandro Furlan et al.   NATURE NEUROSCIENCE

FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential

(2016) Kenneth Lay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging, alopecia, and stem cells

(2016) M. Lei et al.   SCIENCE

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

(2016) H. Matsumura et al.   SCIENCE

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development

(2016) Carolina N. Perdigoto et al.   PLoS Genetics

Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking

(2015) Ling Bai et al.   CELL

Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool

(2015) Kailin R. Mesa et al.   NATURE

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Understanding fibroblast heterogeneity in the skin

(2015) Ryan R. Driskell et al.   TRENDS IN CELL BIOLOGY

mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration

(2015) Zhili Deng et al.   Journal of Molecular Cell Biology

Embryonic attenuated Wnt/β-catenin signaling defines niche location and long-term stem cell fate in hair follicle

(2015) Zijian Xu et al.   eLife

Vitiligo

(2015) Mauro Picardo et al.   Nature Reviews Disease Primers

Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration

(2014) Ya-Chieh Hsu et al.   CELL

The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs

(2014) Michael Rutlin et al.   CELL

Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

(2014) Waleed Rahmani et al.   DEVELOPMENTAL CELL

Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

(2014) J. Goldstein et al.   GENES & DEVELOPMENT

Stress and asthma: Novel insights on genetic, epigenetic, and immunologic mechanisms

(2014) Stacy L. Rosenberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Memory regulatory T cells reside in human skin

(2014) Robert Sanchez Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of psychological stress on irritable bowel syndrome

(2014) Hong-Yan Qin   WORLD JOURNAL OF GASTROENTEROLOGY

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

(2014) B. A. Morgan   Cold Spring Harbor Perspectives in Medicine

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

(2014) Donatello Castellana et al.   PLOS BIOLOGY

A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

(2013) Yusur Al-Nuaimi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

NFIB is a governor of epithelial–melanocyte stem cell behaviour in a shared niche

(2013) Chiung-Ying Chang et al.   NATURE

Nfatc1 orchestrates aging in hair follicle stem cells

(2013) B. E. Keyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

(2013) Maksim V. Plikus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characteristics of the Aging Skin

(2013) Miranda A. Farage et al.   Advances in Wound Care

Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

(2012) Naoki Oshimori et al.   Cell Stem Cell

Eating disorders and the skin

(2012) Renata Strumia   CLINICS IN DERMATOLOGY

Age-associated inflammation inhibits epidermal stem cell function

(2012) J. Doles et al.   GENES & DEVELOPMENT

Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop

(2012) W.-M. Woo et al.   GENES & DEVELOPMENT

Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling

(2012) Miho Kimura-Ueki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

(2012) Panteleimon Rompolas et al.   NATURE

Stress and cardiovascular disease

(2012) Andrew Steptoe et al.   Nature Reviews Cardiology

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

(2012) M. Geyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling

(2012) Rachel Sennett et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche

(2011) Hironobu Fujiwara et al.   CELL

Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

(2011) Eric Festa et al.   CELL

Dynamics between Stem Cells, Niche, and Progeny in the Hair Follicle

(2011) Ya-Chieh Hsu et al.   CELL

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

(2011) Piul Rabbani et al.   CELL

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

(2011) Lishi Li et al.   CELL

Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

(2011) Shintaro Tanimura et al.   Cell Stem Cell

Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

(2011) Isaac Brownell et al.   Cell Stem Cell

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nutrition and hair

(2010) Lynne J. Goldberg et al.   CLINICS IN DERMATOLOGY

Noninvasive method for assessing the human circadian clock using hair follicle cells

(2010) M. Akashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marie Antoinette Syndrome

(2009) Alexander A. Navarini et al.   ARCHIVES OF DERMATOLOGY

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

(2009) Valentina Greco et al.   Cell Stem Cell

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling

(2009) Kevin K. Lin et al.   PLoS Genetics

NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells

(2008) Valerie Horsley et al.   CELL

Identification of White Adipocyte Progenitor Cells In Vivo

(2008) Matthew S. Rodeheffer et al.   CELL

Hair Follicle Stem Cells Are Specified and Function in Early Skin Morphogenesis

(2008) Jonathan A. Nowak et al.   Cell Stem Cell

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties

(2008) M. Rendl et al.   GENES & DEVELOPMENT

Molecular Clocks in Mouse Skin

(2008) Miki Tanioka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hair Follicle Stem Cell-Specific PPARγ Deletion Causes Scarring Alopecia

(2008) Pratima Karnik et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

(2008) Maksim V. Plikus et al.   NATURE

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Aging Alters Functionally Human Dermal Papillary Fibroblasts but Not Reticular Fibroblasts: A New View of Skin Morphogenesis and Aging

(2008) Solène Mine et al.   PLoS One