Immune modulation of hair follicle regeneration

Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss

(2020) Wisoo Shin et al.   DEVELOPMENTAL CELL

Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

(2019) Anubhav N. Mathur et al.   IMMUNITY

A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

(2019) Etienne C.E. Wang et al.   Cell Stem Cell

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth

(2019) Sun-Young Yoon et al.   PLoS One

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

(2019) Daniel Peña‐Jimenez et al.   EMBO JOURNAL

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Stem cell–driven lymphatic remodeling coordinates tissue regeneration

(2019) Shiri Gur-Cohen et al.   SCIENCE

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis

(2018) Michael W. Hughes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX 3 CR1- and TGF-β1–Dependent Manner

(2018) Waleed Rahmani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

(2018) Matthew J. Harries et al.   TRENDS IN MOLECULAR MEDICINE

Macrophages Regulate Schwann Cell Maturation after Nerve Injury

(2018) Jo Anne Stratton et al.   Cell Reports

Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease

(2018) Shruti Naik et al.   CELL

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

(2018) Chae Ho Lim et al.   Nature Communications

Tofacitinib for the treatment of severe alopecia areata and variants: A study of 90 patients

(2017) Lucy Y. Liu et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

(2016) Amanda M. Nelson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression

(2016) Nicole Amberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis

(2016) Michael K. Lichtman et al.   WOUND REPAIR AND REGENERATION

Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement

(2015) Gary S Collins et al.   BMC Medicine

Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

(2015) Chih-Chiang Chen et al.   CELL

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy

(2015) Philip L. Tong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

(2015) Takeya Adachi et al.   NATURE MEDICINE

Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors

(2015) Dario R Lemos et al.   NATURE MEDICINE

Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

(2015) S. Harel et al.   Science Advances

Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration

(2014) Ya-Chieh Hsu et al.   CELL

BMP Signaling and Its pSMAD1/5 Target Genes Differentially Regulate Hair Follicle Stem Cell Lineages

(2014) Maria Genander et al.   Cell Stem Cell

Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

(2014) Waleed Rahmani et al.   DEVELOPMENTAL CELL

Memory regulatory T cells reside in human skin

(2014) Robert Sanchez Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Alopecia areata occurring during anti-TNF therapy: A national multicenter prospective study

(2014) Marie Tauber et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Preparing the ground for tissue regeneration: from mechanism to therapy

(2014) Stuart J Forbes et al.   NATURE MEDICINE

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

(2014) Luzhou Xing et al.   NATURE MEDICINE

Emerging interactions between skin stem cells and their niches

(2014) Ya-Chieh Hsu et al.   NATURE MEDICINE

The Monocyte to Macrophage Transition in the Murine Sterile Wound

(2014) Meredith J. Crane et al.   PLoS One

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

(2014) Donatello Castellana et al.   PLOS BIOLOGY

Effects of Low-Dose Recombinant Interleukin 2 to Promote T-Regulatory Cells in Alopecia Areata

(2014) Emeline Castela et al.   JAMA Dermatology

Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair

(2013) J. A. Stefater et al.   BLOOD

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

(2013) Jose E. Heredia et al.   CELL

Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline

(2013) W. Chi et al.   DEVELOPMENT

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

(2013) I. K. Gratz et al.   JOURNAL OF IMMUNOLOGY

Loss of γδ T Cells Results in Hair Cycling Defects

(2013) Jennifer E. Kloepper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Bone Morphogenetic Protein Signaling Suppresses Wound-Induced Skin Repair by Inhibiting Keratinocyte Proliferation and Migration

(2013) Christopher J. Lewis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

(2013) Xiaojie Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche

(2013) Matthew J Harries et al.   JOURNAL OF PATHOLOGY

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells

(2013) William R Heath et al.   NATURE IMMUNOLOGY

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

(2013) Denise Gay et al.   NATURE MEDICINE

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

(2012) Naoki Oshimori et al.   Cell Stem Cell

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Dermal  -catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

(2012) D. Chen et al.   DEVELOPMENT

Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors

(2012) Carlos Clavel et al.   DEVELOPMENTAL CELL

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration

(2012) Panteleimon Rompolas et al.   NATURE

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

(2012) Keisuke Nagao et al.   NATURE IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Alopecia Areata

(2012) Amos Gilhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deficiency of CX3CR1 delays burn wound healing and is associated with reduced myeloid cell recruitment and decreased sub-dermal angiogenesis

(2011) Anthony J.P. Clover et al.   BURNS

Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

(2011) Eric Festa et al.   CELL

Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

(2011) Isaac Brownell et al.   Cell Stem Cell

The First Description of the Hair Follicle Bulge by Franz von Leydig

(2011) Marlon R. Schneider   DERMATOLOGY

The Multitasking Organ: Recent Insights into Skin Immune Function

(2011) Paola Di Meglio et al.   IMMUNITY

Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis

(2010) Yasunori Ito et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

(2010) Lynn Petukhova et al.   NATURE

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia

(2009) M.P. Hoang et al.   BRITISH JOURNAL OF DERMATOLOGY

SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

(2009) Jeffrey Biernaskie et al.   Cell Stem Cell

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

(2009) Valentina Greco et al.   Cell Stem Cell

Increased Th17 cells are accompanied by FoxP3+ Treg cell accumulation and correlated with psoriasis disease severity

(2009) Li Zhang et al.   CLINICAL IMMUNOLOGY

γδ T Cells and the Lymphoid Stress-Surveillance Response

(2009) Adrian C. Hayday   IMMUNITY

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Melanocytes: A possible autoimmune target in alopecia areata

(2009) Stephanie Trautman et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

(2008) L. Landsman et al.   BLOOD

Management of primary cicatricial alopecias: options for treatment

(2008) M.J. Harries et al.   BRITISH JOURNAL OF DERMATOLOGY

Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome

(2008) M. Halabi-Tawil et al.   BRITISH JOURNAL OF DERMATOLOGY

NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells

(2008) Valerie Horsley et al.   CELL

Hair Follicle Stem Cells Are Specified and Function in Early Skin Morphogenesis

(2008) Jonathan A. Nowak et al.   Cell Stem Cell

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

(2008) Maksim V. Plikus et al.   NATURE

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS