Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

Midlife and Late-Life Body Mass Index and Late-Life Dementia: Results from a Prospective Population-Based Cohort

(2018) Anna-Maija Tolppanen et al.   JOURNAL OF ALZHEIMERS DISEASE

2003-2013: A Decade of Body Mass Index, Alzheimer's Disease, and Dementia

(2018) Tim L. Emmerzaal et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of Stress and Stress Hormones on Amyloid-β Protein and Plaque Deposition

(2017) Hongxin Dong et al.   JOURNAL OF ALZHEIMERS DISEASE

Big mice die young but large animals live longer

(2016) Mikhail V. Blagosklonny   Aging-US

Growth hormone and aging: A challenging controversy

(2016) Andrzej Bartke   Clinical Interventions in Aging

Protection of Hypoglycemia-Induced Neuronal Death by β-Hydroxybutyrate Involves the Preservation of Energy Levels and Decreased Production of Reactive Oxygen Species

(2015) Alberto Julio-Amilpas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Omega-3 polyunsaturated fatty acids ameliorate neuroinflammation and mitigate ischemic stroke damage through interactions with astrocytes and microglia

(2015) Adib Zendedel et al.   JOURNAL OF NEUROIMMUNOLOGY

Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons

(2015) Oliver Takach et al.   NEUROBIOLOGY OF AGING

Peripheral and central effects of repeated social defeat stress: Monocyte trafficking, microglial activation, and anxiety

(2015) B.F. Reader et al.   NEUROSCIENCE

Adipose tissue as an immunological organ

(2015) Ryan W. Grant et al.   Obesity

Effect of n−3 PUFA supplementation on cognitive function throughout the life span from infancy to old age: a systematic review and meta-analysis of randomized controlled trials

(2014) Jingjing Jiao et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The influence of smoking, sedentary lifestyle and obesity on cognitive impairment-free life expectancy

(2014) Kaarin Jane Anstey et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

20 YEARS OF LEPTIN: Role of leptin in energy homeostasis in humans

(2014) Michael Rosenbaum et al.   JOURNAL OF ENDOCRINOLOGY

IFN-γ and TNF-α Are Involved During Alzheimer Disease Progression and Correlate with Nitric Oxide Production: A Study in Algerian Patients

(2014) Mourad Belkhelfa et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function

(2014) Anusha Jayaraman et al.   Journal of Neuroinflammation

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

(2014) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease

(2014) Cecilia E. Hanzel et al.   NEUROBIOLOGY OF AGING

Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?

(2014) Kristl Vonck et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Effect and Mechanism of Growth Hormone Replacement on Cognitive Function in Rats with Traumatic Brain Injury

(2014) Hao Zhang et al.   PLoS One

Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle

(2014) A. B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-beta neuroprotection mediated by a targeted antioxidant

(2014) Courtney R. Giordano et al.   Scientific Reports

n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice

(2014) Debora Cutuli et al.   Frontiers in Aging Neuroscience

Buying time: a rationale for examining the use of circadian rhythm and sleep interventions to delay progression of mild cognitive impairment to Alzheimer’s disease

(2014) Glenn J. Landry et al.   Frontiers in Aging Neuroscience

Deamidated Lipocalin‐2 Induces Endothelial Dysfunction and Hypertension in Dietary Obese Mice

(2014) Erfei Song et al.   Journal of the American Heart Association

The genetics of Alzheimer's disease

(2014) Eva Bagyinszky et al.   Clinical Interventions in Aging

Voluntary exercise can strengthen the circadian system in aged mice

(2013) T. L. Leise et al.   AGE

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain

(2013) F J Steyn et al.   JOURNAL OF ENDOCRINOLOGY

High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System

(2013) Silke Timmermans et al.   Journal of Neuroimmune Pharmacology

Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. The SMART-MR study

(2013) Minke Kooistra et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Systematic Review: Are Overweight and Obese Individuals Impaired on Behavioural Tasks of Executive Functioning?

(2013) Sian Fitzpatrick et al.   NEUROPSYCHOLOGY REVIEW

Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms

(2013) Linnea R. Freeman et al.   NUTRITIONAL NEUROSCIENCE

Sleep architecture variation: a mediator of metabolic disturbance in individuals with major depressive disorder

(2013) P.A. Kudlow et al.   SLEEP MEDICINE

ω-3 Fatty Acids in the Prevention of Cognitive Decline in Humans

(2013) Tommy Cederholm et al.   Advances in Nutrition

Circadian clocks and memory: time-place learning

(2013) C. K. Mulder et al.   Frontiers in Molecular Neuroscience

The Role of Mobility as a Protective Factor of Cognitive Functioning in Aging Adults

(2013) Emily Zhao et al.   Sports Health-A Multidisciplinary Approach

Growth hormone reverses streptozotocin-induced cognitive impairments in male mice

(2012) Erika Enhamre-Brolin et al.   BEHAVIOURAL BRAIN RESEARCH

Social Jetlag and Obesity

(2012) Till Roenneberg et al.   CURRENT BIOLOGY

Adipose tissue oxygen tension

(2012) Gijs H. Goossens et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Obesity increases cerebrocortical reactive oxygen species and impairs brainfunction

(2012) Linnea R. Freeman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced Adipose Afferent Reflex Contributes to Sympathetic Activation in Diet-Induced Obesity Hypertension

(2012) Xiao-Qing Xiong et al.   HYPERTENSION

Reduction in Inflammation and the Expression of Amyloid Precursor Protein and Other Proteins Related to Alzheimer's Disease following Gastric Bypass Surgery

(2012) Husam Ghanim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

(2012) Esther Fuente-Martín et al.   JOURNAL OF CLINICAL INVESTIGATION

TNFα gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice

(2012) Jérôme Salles et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Polyunsaturated fatty acids as putative cognitive enhancers

(2012) S. Yehuda   MEDICAL HYPOTHESES

Synaptic plasticity in neuronal circuits regulating energy balance

(2012) Lori M Zeltser et al.   NATURE NEUROSCIENCE

The vagus nerve and the inflammatory reflex—linking immunity and metabolism

(2012) Valentin A. Pavlov et al.   Nature Reviews Endocrinology

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats

(2012) K. Marosi et al.   NEUROSCIENCE

Neurobehavioural correlates of body mass index and eating behaviours in adults: A systematic review

(2012) Uku Vainik et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

(2012) Terry L. Davidson et al.   PHYSIOLOGY & BEHAVIOR

Exercise protects against high-fat diet-induced hypothalamic inflammation

(2012) Chun-Xia Yi et al.   PHYSIOLOGY & BEHAVIOR

Short-Term Long Chain Omega3 Diet Protects from Neuroinflammatory Processes and Memory Impairment in Aged Mice

(2012) Virginie F. Labrousse et al.   PLoS One

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

(2012) S. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

n-3 Polyunsaturated fatty acids in animal models with neuroinflammation

(2012) Sarah K. Orr et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice

(2011) Rachel A. Kohman et al.   BRAIN BEHAVIOR AND IMMUNITY

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

(2011) Lei Cao et al.   Cell Metabolism

Dietary Omega 3 Polyunsaturated Fatty Acids and Alzheimers Disease: Interaction with Apolipoprotein E Genotype

(2011) P. Barberger-Gateau et al.   Current Alzheimer Research

Metabolic and hedonic drives in the neural control of appetite: who is the boss?

(2011) Hans-Rudolf Berthoud   CURRENT OPINION IN NEUROBIOLOGY

Cytokine Signaling Modulates Blood-Brain Barrier Function

(2011) Weihong Pan et al.   CURRENT PHARMACEUTICAL DESIGN

Tumor necrosis factor receptor cross-talk

(2011) Petrus J. W. Naudé et al.   FEBS Journal

Functional relationship between obesity and male reproduction: from humans to animal models

(2011) K. J. Teerds et al.   HUMAN REPRODUCTION UPDATE

Adipose Tissue, Inflammation and Atherosclerosis

(2011) Birgit Gustafson   Journal of Atherosclerosis and Thrombosis

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence

(2011) Han Yan et al.   JOURNAL OF ENDOCRINOLOGY

Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice

(2011) Sook-Eun Park et al.   Journal of Neuroinflammation

Vascular biology of metabolic syndrome

(2011) Daynene Vykoukal et al.   JOURNAL OF VASCULAR SURGERY

Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling

(2011) Aderbal S. Aguiar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nutritional Strategies for Successful Aging

(2011) Jean Woo   MEDICAL CLINICS OF NORTH AMERICA

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Midlife overweight and obesity increase late-life dementia risk: A population-based twin study

(2011) W. L. Xu et al.   NEUROLOGY

Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats

(2011) R.C. Li et al.   NEUROSCIENCE

Stress revisited: A critical evaluation of the stress concept

(2011) J.M. Koolhaas et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Immune system to brain signaling: Neuropsychopharmacological implications

(2011) Lucile Capuron et al.   PHARMACOLOGY & THERAPEUTICS

A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death

(2011) Roman Fischer et al.   PLoS One

Central insulin and leptin-mediated autonomic control of glucose homeostasis

(2011) Joseph S. Marino et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adipose proinflammatory cytokine expression through sympathetic system is associated with hyperglycemia and insulin resistance in a rat ischemic stroke model

(2010) Ya-Yu Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The cholinergic system, circadian rhythmicity, and time memory

(2010) R.A. Hut et al.   BEHAVIOURAL BRAIN RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

(2010) Joshua P. Thaler et al.   ENDOCRINOLOGY

Modulation of hypothalamic PTP1B in the TNF-α-induced insulin and leptin resistance

(2010) Paty Karoll Picardi et al.   FEBS LETTERS

ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody

(2010) Kirstin A. Zettlitz et al.   mAbs

The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors

(2010) Fernando Cordido et al.   MEDIATORS OF INFLAMMATION

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

(2010) Piet Eikelenboom et al.   Neurodegenerative Diseases

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

(2010) W. A. Banks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-10 attenuates TNF- -induced NF B pathway activation and cardiomyocyte apoptosis

(2009) S. Dhingra et al.   CARDIOVASCULAR RESEARCH

Ten Putative Contributors to the Obesity Epidemic

(2009) Emily J. McAllister et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Growth hormone, arginine and exercise

(2009) Jill A Kanaley   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes

(2009) Swapnil N. Rajpathak et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

Natural Addiction

(2009) Bartley G. Hoebel et al.   Journal of Addiction Medicine

A Humanized Tumor Necrosis Factor Receptor 1 (TNFR1)-specific Antagonistic Antibody for Selective Inhibition of Tumor Necrosis Factor (TNF) Action

(2009) Roland E. Kontermann et al.   JOURNAL OF IMMUNOTHERAPY

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury

(2009) G J Norman et al.   MOLECULAR PSYCHIATRY

Neural correlates of Alzheimer's disease and mild cognitive impairment: A systematic and quantitative meta-analysis involving 1351 patients

(2009) Matthias L. Schroeter et al.   NEUROIMAGE

From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation

(2009) L. Lionetti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Impact of 6-month Caloric Restriction on Autonomic Nervous System Activity in Healthy, Overweight, Individuals

(2009) Lilian de Jonge et al.   Obesity

‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders

(2009) Kent C. Berridge   PHYSIOLOGY & BEHAVIOR

Cellular hypoxia and adipose tissue dysfunction in obesity

(2009) I. Stuart Wood et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Robust Docosahexaenoic Acid–Mediated Neuroprotection in a Rat Model of Transient, Focal Cerebral Ischemia

(2009) Ludmila Belayev et al.   STROKE

Insulin, leptin and reward

(2009) Jon F. Davis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Stress-induced obesity and the emotional nervous system

(2009) Mary F. Dallman   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic Psychosocial Stress Exacerbates Impairment of Cognition and Long-Term Potentiation in β-Amyloid Rat Model of Alzheimer's Disease

(2008) Marisa Srivareerat et al.   BIOLOGICAL PSYCHIATRY

Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier

(2008) Akihiko Urayama et al.   ENDOCRINOLOGY

Interleukin-10 regulates TNF-α−converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism

(2008) Fionula M. Brennan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

(2008) Mathilde Gavillet et al.   GLIA

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study

(2008) Marjo H. Eskelinen et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

(2008) J Ye   INTERNATIONAL JOURNAL OF OBESITY

The Effects of Central Adiposity on Growth Hormone (GH) Response to GH-Releasing Hormone-Arginine Stimulation Testing in Men

(2008) Hideo Makimura et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials

(2008) Armando P. Signore et al.   JOURNAL OF NEUROCHEMISTRY

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Fasting is neuroprotective following traumatic brain injury

(2008) Laurie M. Davis et al.   JOURNAL OF NEUROSCIENCE RESEARCH

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory

(2008) John I Malone et al.   PEDIATRIC DIABETES