Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

(2022) Marijana Vujkovic et al.   NATURE GENETICS

Multiomics study of nonalcoholic fatty liver disease

(2022) Gardar Sveinbjornsson et al.   NATURE GENETICS

Further evidence supporting a potential role for ADH1B in obesity

(2021) Liza D. Morales et al.   Scientific Reports

Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease

(2021) Oveis Jamialahmadi et al.   GASTROENTEROLOGY

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

(2021) Vincent L. Chen et al.   Nature Communications

Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction

(2021) Nicholette D Palmer et al.   HUMAN MOLECULAR GENETICS

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

(2021) Han Zeng et al.   Molecular Metabolism

ADH1B*2 is Associated With Reduced Severity of Nonalcoholic Fatty Liver Disease in Adults, Independent of Alcohol Consumption

(2020) Vilar-Gomez Eduardo et al.   GASTROENTEROLOGY

LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover

(2020) Yuki Tanaka et al.   GUT

Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping

(2020) Zhipeng Liu et al.   JOURNAL OF HEPATOLOGY

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis

(2020) Constantinos A. Parisinos et al.   JOURNAL OF HEPATOLOGY

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

(2020) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans

(2020) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Genome-wide Association Study for Alcohol-related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1.

(2020) Hamish Innes et al.   GASTROENTEROLOGY

Hepatic Deletion of Mboat7 (Lpiat1) Causes Activation of SREBP-1c and Fatty Liver

(2020) Mingfeng Xia et al.   JOURNAL OF LIPID RESEARCH

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study

(2020) Connor A. Emdin et al.   GASTROENTEROLOGY

A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction

(2020) Bratati Kahali et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores

(2020) Cristiana Bianco et al.   JOURNAL OF HEPATOLOGY

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Insulin and Insulin Receptors in Adipose Tissue Development

(2019) Angelo Cignarelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

(2019) Yang Wang et al.   HEPATOLOGY

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

(2019) Soumik BasuRay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

(2019) Bahram Namjou et al.   BMC Medicine

An intronic variant in the GCKR gene is associated with multiple lipids

(2019) Lilian Fernandes Silva et al.   Scientific Reports

Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

(2019) Ji-Yeon Shin et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic variants that associate with cirrhosis have pleiotropic effects on human traits

(2019) Vincent L. Chen et al.   LIVER INTERNATIONAL

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipid transfer proteins in the assembly of apoB-containing lipoproteins

(2018) Alaa Sirwi et al.   JOURNAL OF LIPID RESEARCH

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews

(2018) Sheng Gu et al.   Genes

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease

(2018) Yanling Ma et al.   HEPATOLOGY

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals

(2017) Bo Kobberø Lauridsen et al.   EUROPEAN HEART JOURNAL

Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis

(2017) Michael S. Middleton et al.   GASTROENTEROLOGY

Polymorphism of receptor-type tyrosine-protein phosphatase delta gene in the development of non-alcoholic fatty liver disease

(2017) Shunsuke Nakajima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

(2017) P. Dongiovanni et al.   JOURNAL OF INTERNAL MEDICINE

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

(2017) Stefan Stender et al.   NATURE GENETICS

IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk

(2017) Yaoyu Zou et al.   EBioMedicine

Hormonal and Metabolite Regulation of Hepatic Glucokinase

(2016) Loranne Agius   Annual Review of Nutrition

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Response to Hartwig and Davies

(2016) Jack Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

(2016) Lucie Popineau et al.   MOLECULAR AND CELLULAR BIOLOGY

FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?

(2016) Kathrin Landgraf et al.   PLoS One

Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance

(2015) Pär Steneberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels

(2015) Paola Portillo-Sanchez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα

(2015) Robert C. Bauer et al.   JOURNAL OF CLINICAL INVESTIGATION

GWAS-Identified Common Variants With Nonalcoholic Fatty Liver Disease in Chinese Children

(2015) Xiao-Rui Shang et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

(2015) Mohammed Eslam et al.   Nature Communications

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium

(2014) Nicholette D. Palmer et al.   DIABETES

MTP −493G>T Polymorphism and Susceptibility to Nonalcoholic Fatty Liver Disease: A Meta-Analysis

(2014) Wei Zheng et al.   DNA AND CELL BIOLOGY

Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits

(2014) Aya Kitamoto et al.   ENDOCRINE JOURNAL

TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions

(2014) Yuumi Ishizuka et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Analysis of the TRIB 1 Associated Locus Linked to Plasma Triglycerides and Coronary Artery Disease

(2014) Adrianna Douvris et al.   Journal of the American Heart Association

Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988–1994

(2013) Mariana Lazo et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study

(2013) Mary F. Feitosa et al.   ATHEROSCLEROSIS

Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan

(2013) Takuya Kitamoto et al.   HUMAN GENETICS

Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans: The Jackson Heart Study

(2012) Jiankang Liu et al.   ATHEROSCLEROSIS

Symptomatic lipid storage in carriers for the PNPLA2 gene

(2012) Mirian C H Janssen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Mitochondrial Amidoxime-reducing Component (mARC1) Is a Novel Signal-anchored Protein of the Outer Mitochondrial Membrane

(2012) Julian M. Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease

(2012) Salvatore Petta et al.   JOURNAL OF HEPATOLOGY

Multiple functions of microsomal triglyceride transfer protein

(2012) M Mahmood Hussain et al.   Nutrition & Metabolism

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

(2012) Caroline S. Fox et al.   PLoS Genetics

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Genetic Epidemiology of COPD (COPDGene) Study Design

(2010) Elizabeth A. Regan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

(2010) P. Dongiovanni et al.   GUT

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

The Association of Coronary Artery Calcification and Carotid Artery Intima-Media Thickness With Distinct, Traditional Coronary Artery Disease Risk Factors in Asymptomatic Adults

(2008) E. Rampersaud et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis

(2008) Stuart Macgregor et al.   HUMAN MOLECULAR GENETICS

Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study

(2008) Elizabeth K Speliotes et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE