Effect of Buffer pH and Concentration on the Dissolution Rates of Sodium Indomethacin–Copovidone and Indomethacin–Copovidone Amorphous Solid Dispersions

Dissolution Mechanisms of Amorphous Solid Dispersions: A Close Look at the Dissolution Interface

(2023) Alexandru Deac et al.   Molecular Pharmaceutics

Drug Release from Surfactant-Containing Amorphous Solid Dispersions: Mechanism and Role of Surfactant in Release Enhancement

(2023) Ruochen Yang et al.   PHARMACEUTICAL RESEARCH

Release Enhancement by Plasticizer Inclusion for Amorphous Solid Dispersions Containing High Tg Drugs

(2023) Clara E. Correa-Soto et al.   PHARMACEUTICAL RESEARCH

Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen

(2022) Po-Chang Chiang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Impact of Surfactants on the Performance of Clopidogrel-Copovidone Amorphous Solid Dispersions: Increased Drug Loading and Stabilization of Nanodroplets

(2022) Clara E. Correa Soto et al.   PHARMACEUTICAL RESEARCH

Combining enabling formulation strategies to generate supersaturated solutions of delamanid: In situ salt formation during amorphous solid dispersion fabrication for more robust release profiles

(2022) Tu Van Duong et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Using Tiny-TIM Dissolution and In Silico Simulation to Accelerate Oral Product Development of a BCS Class II Compound

(2022) Laibin Luo et al.   AAPS PHARMSCITECH

Release mechanisms of amorphous solid dispersions: Role of drug-polymer phase separation and morphology

(2022) Ruochen Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Combining drug salt formation with amorphous solid dispersions – a double edged sword

(2022) Tze Ning Hiew et al.   JOURNAL OF CONTROLLED RELEASE

Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

(2022) Christopher McBride et al.   Journal of Medicinal Chemistry

Dissolution Mechanisms of Amorphous Solid Dispersions: Role of Drug Load and Molecular Interactions

(2022) Alexandru Deac et al.   Molecular Pharmaceutics

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

(2021) Brian S. Safina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Release and Nanodroplet Formation from Amorphous Solid Dispersions: Insight into the Roles of Drug Physicochemical Properties and Polymer Selection

(2021) Ruochen Yang et al.   MOLECULAR PHARMACEUTICS

Impact of Drug–Polymer Intermolecular Interactions on Dissolution Performance of Copovidone-Based Amorphous Solid Dispersions

(2021) Chailu Que et al.   MOLECULAR PHARMACEUTICS

Balancing Solid-State Stability and Dissolution Performance of Lumefantrine Amorphous Solid Dispersions: The Role of Polymer Choice and Drug–Polymer Interactions

(2021) Tze Ning Hiew et al.   MOLECULAR PHARMACEUTICS

Effect of Counterions on Dissolution of Amorphous Solid Dispersions Studied by Surface Area Normalized Dissolution

(2021) Yinshan Chen et al.   MOLECULAR PHARMACEUTICS

Increasing Drug Loading of Weakly Acidic Telmisartan in Amorphous Solid Dispersions through pH Modification during Hot-Melt Extrusion

(2021) Stephen A. Thompson et al.   MOLECULAR PHARMACEUTICS

Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization and glass transition

(2020) Sugandha Saboo et al.   MOLECULAR PHARMACEUTICS

A Rational Design of a Biphasic Dissolution Setup—Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion

(2020) Alexander Denninger et al.   Pharmaceutics

Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products

(2020) Palpandi Pandi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Patterns of drug release as a function of drug loading from amorphous solid dispersions: A comparison of five different polymers.

(2020) Sugandha Saboo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

(2019) Athanasios Mantas et al.   Pharmaceutics

Insights into the Dissolution Mechanism of Ritonavir–Copovidone Amorphous Solid Dispersions: Importance of Congruent Release for Enhanced Performance

(2019) Anura S. Indulkar et al.   MOLECULAR PHARMACEUTICS

Congruent release of drug and polymer: A “sweet spot” in the dissolution of amorphous solid dispersions

(2019) Sugandha Saboo et al.   JOURNAL OF CONTROLLED RELEASE

Impact of Surfactant and Surfactant-Polymer Interaction on Desupersaturation of Clotrimazole

(2019) Wei Zhang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Insights into the Dissolution Behavior of Ledipasvir–Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions

(2019) Chailu Que et al.   MOLECULAR PHARMACEUTICS

Surface area normalized dissolution to study differences in itraconazole-copovidone solid dispersions prepared by spray-drying and hot melt extrusion

(2018) Vivekanand Bhardwaj et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of Accuracy of Amorphous Solubility Advantage Calculation by Comparison with Experimental Solubility Measurement in Buffer and Biorelevant Media

(2018) Wei Zhang et al.   MOLECULAR PHARMACEUTICS

Physical Stability and Dissolution Behavior of Ketoconazole–Organic Acid Coamorphous Systems

(2018) Michelle Fung et al.   MOLECULAR PHARMACEUTICS

Crystallization from Supersaturated Solutions: Role of Lecithin and Composite Simulated Intestinal Fluid

(2018) Anura S. Indulkar et al.   PHARMACEUTICAL RESEARCH

Effect of Organic Acids on Molecular Mobility, Physical Stability, and Dissolution of Ternary Ketoconazole Spray-Dried Dispersions

(2018) Michelle H. Fung et al.   MOLECULAR PHARMACEUTICS

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

(2017) Bart Hens et al.   MOLECULAR PHARMACEUTICS

Indomethacin-Kollidon VA64 Extrudates: A Mechanistic Study of pH-Dependent Controlled Release

(2016) Francesco Tres et al.   MOLECULAR PHARMACEUTICS

Initial Drug Dissolution from Amorphous Solid Dispersions Controlled by Polymer Dissolution and Drug-Polymer Interaction

(2016) Yuejie Chen et al.   PHARMACEUTICAL RESEARCH

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

(2015) Andiliy Lai et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo Predictive Dissolution: Comparing the Effect of Bicarbonate and Phosphate Buffer on the Dissolution of Weak Acids and Weak Bases

(2015) Brian J. Krieg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

pH-Dependent Liquid–Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs

(2015) Anura S. Indulkar et al.   MOLECULAR PHARMACEUTICS

Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

(2013) Line Hagner Nielsen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The Role of BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) in Drug Development

(2012) Leslie Z. Benet   JOURNAL OF PHARMACEUTICAL SCIENCES

pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties

(2012) Yi-Ling Hsieh et al.   PHARMACEUTICAL RESEARCH

The roles of acidifiers in solid dispersions and physical mixtures

(2009) Thao Truong-Dinh Tran et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Co-solvent solubilization of some poorly-soluble antidiabetic drugs

(2009) Neelam Seedher et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY