Dissolution Mechanisms of Amorphous Solid Dispersions: Role of Drug Load and Molecular Interactions
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Dissolution Mechanisms of Amorphous Solid Dispersions: Role of Drug Load and Molecular Interactions
Authors
Keywords
-
Journal
Molecular Pharmaceutics
Volume 20, Issue 1, Pages 722-737
Publisher
American Chemical Society (ACS)
Online
2022-12-22
DOI
10.1021/acs.molpharmaceut.2c00892
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Explaining the Release Mechanism of Ritonavir/PVPVA Amorphous Solid Dispersions
- (2022) Adrian Krummnow et al. Pharmaceutics
- Effect of Polymer Species on Maximum Aqueous Phase Supersaturation Revealed by Quantitative Nuclear Magnetic Resonance Spectroscopy
- (2021) Keisuke Ueda et al. MOLECULAR PHARMACEUTICS
- Interaction of Polymers with Enzalutamide Nanodroplets—Impact on Droplet Properties and Induction Times
- (2021) Venecia R. Wilson et al. MOLECULAR PHARMACEUTICS
- Drug Release and Nanodroplet Formation from Amorphous Solid Dispersions: Insight into the Roles of Drug Physicochemical Properties and Polymer Selection
- (2021) Ruochen Yang et al. MOLECULAR PHARMACEUTICS
- Impact of Drug–Polymer Intermolecular Interactions on Dissolution Performance of Copovidone-Based Amorphous Solid Dispersions
- (2021) Chailu Que et al. MOLECULAR PHARMACEUTICS
- Variable-Temperature NMR Analysis of the Thermodynamics of Polymer Partitioning between Aqueous and Drug-Rich Phases and Its Significance for Amorphous Formulations
- (2021) Keisuke Ueda et al. MOLECULAR PHARMACEUTICS
- Simple Calculation of Phase Diagrams for Liquid-Liquid Phase Separation in Solutions of Two Macromolecular Solute Species
- (2020) Allen P. Minton JOURNAL OF PHYSICAL CHEMISTRY B
- Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization and glass transition
- (2020) Sugandha Saboo et al. MOLECULAR PHARMACEUTICS
- Evidence for Halogen Bonding in Amorphous Solid Dispersions
- (2020) Chailu Que et al. CRYSTAL GROWTH & DESIGN
- Amorphous solid dispersions containing residual crystallinity: Influence of seed properties and polymer adsorption on dissolution performance
- (2020) Dana E. Moseson et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Impact of Hypromellose Acetate Succinate Grade on Drug Amorphous Solubility and In Vitro Membrane Transport
- (2020) Keisuke Ueda et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Patterns of drug release as a function of drug loading from amorphous solid dispersions: A comparison of five different polymers.
- (2020) Sugandha Saboo et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Insights into the Dissolution Mechanism of Ritonavir–Copovidone Amorphous Solid Dispersions: Importance of Congruent Release for Enhanced Performance
- (2019) Anura S. Indulkar et al. MOLECULAR PHARMACEUTICS
- Microstructure Formation for Improved Dissolution Performance of Lopinavir Amorphous Solid Dispersions
- (2019) Na Li et al. MOLECULAR PHARMACEUTICS
- Congruent release of drug and polymer: A “sweet spot” in the dissolution of amorphous solid dispersions
- (2019) Sugandha Saboo et al. JOURNAL OF CONTROLLED RELEASE
- Impact of phase separation morphology on release mechanism of amorphous solid dispersions
- (2019) Yi Rang Han et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Insights into the Dissolution Behavior of Ledipasvir–Copovidone Amorphous Solid Dispersions: Role of Drug Loading and Intermolecular Interactions
- (2019) Chailu Que et al. MOLECULAR PHARMACEUTICS
- Paclitaxel Crystal Seeds with Different Intrinsic Properties and Their Impact on Dissolution of Paclitaxel-HPMCAS Amorphous Solid Dispersions
- (2018) Chailu Que et al. CRYSTAL GROWTH & DESIGN
- Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery – An update
- (2018) Scott V. Jermain et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The application of temperature-composition phase diagrams for hot melt extrusion processing of amorphous solid dispersions to prevent residual crystallinity
- (2018) Dana E. Moseson et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Relationship between amorphous solid dispersion in vivo absorption and in vitro dissolution: phase behavior during dissolution, speciation, and membrane mass transport
- (2018) Venecia Wilson et al. JOURNAL OF CONTROLLED RELEASE
- Phase Behavior of Ritonavir Amorphous Solid Dispersions during Hydration and Dissolution
- (2017) Hitesh S. Purohit et al. PHARMACEUTICAL RESEARCH
- Plait point in ternary system with a miscibility gap: Analysis of the procedures involved in its determination and development of novel procedures
- (2016) Gaetano Mangiapia et al. FLUID PHASE EQUILIBRIA
- Mechanism of Dissolution-Induced Nanoparticle Formation from a Copovidone-Based Amorphous Solid Dispersion
- (2016) Paul Harmon et al. MOLECULAR PHARMACEUTICS
- Exploiting the Phenomenon of Liquid–Liquid Phase Separation for Enhanced and Sustained Membrane Transport of a Poorly Water-Soluble Drug
- (2016) Anura S. Indulkar et al. MOLECULAR PHARMACEUTICS
- Identifying the mechanisms of drug release from amorphous solid dispersions using MRI and ATR-FTIR spectroscopic imaging
- (2015) Kateřina Punčochová et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Comparative Study of Different Methods for the Prediction of Drug–Polymer Solubility
- (2015) Matthias Manne Knopp et al. MOLECULAR PHARMACEUTICS
- Phase Separation Kinetics in Amorphous Solid Dispersions Upon Exposure to Water
- (2015) Hitesh S. Purohit et al. MOLECULAR PHARMACEUTICS
- Glass–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir
- (2015) Laura I. Mosquera-Giraldo et al. MOLECULAR PHARMACEUTICS
- Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type
- (2015) Matthew J. Jackson et al. MOLECULAR PHARMACEUTICS
- Assessment of the Amorphous “Solubility” of a Group of Diverse Drugs Using New Experimental and Theoretical Approaches
- (2014) Luis Almeida e Sousa et al. MOLECULAR PHARMACEUTICS
- Liquid–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations
- (2013) Grace A. Ilevbare et al. CRYSTAL GROWTH & DESIGN
- Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir
- (2013) Grace A. Ilevbare et al. MOLECULAR PHARMACEUTICS
- Classification of the Crystallization Behavior of Amorphous Active Pharmaceutical Ingredients in Aqueous Environments
- (2013) Bernard Van Eerdenbrugh et al. PHARMACEUTICAL RESEARCH
- Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide
- (2011) Taro Yamashita et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Dissolution and Precipitation Behavior of Amorphous Solid Dispersions
- (2011) David E. Alonzo et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Drug–Polymer Solubility and Miscibility: Stability Consideration and Practical Challenges in Amorphous Solid Dispersion Development
- (2010) Feng Qian et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Binodal Compositions of Polyelectrolyte Complexes
- (2010) Evan Spruijt et al. MACROMOLECULES
- Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis
- (2009) Sharad B. Murdande et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Phase Behavior of Poly(vinylpyrrolidone) Containing Amorphous Solid Dispersions in the Presence of Moisture
- (2009) Alfred C. F. Rumondor et al. MOLECULAR PHARMACEUTICS
- The influence of lead discovery strategies on the properties of drug candidates
- (2009) György M. Keserü et al. NATURE REVIEWS DRUG DISCOVERY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More