Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen
Authors
Keywords
Triskelion's Gastro-Intestinal Model (Tiny-TIM), Exposure, In vitro-in vivo correlation, Motrin IB, Multi-compartment pharmacokinetic model
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2022-02-02
DOI
10.1016/j.xphs.2022.01.024
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Utilizing Tiny-TIM to Assess the Effect of Acid-Reducing Agents on the Absorption of Orally Administered Drugs
- (2021) Jia Liu et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP
- (2020) Marival Bermejo et al. Pharmaceutics
- Combined Application of MRI and the Salivary Tracer Technique to Determine the in Vivo Disintegration Time of Immediate Release Formulation Administered to Healthy, Fasted Subjects
- (2019) Maximilian Sager et al. MOLECULAR PHARMACEUTICS
- An Integrated Analysis of Solid Form Change Impact on Solubility and Permeability: Case Study of Oral Exposure in Rats of an RAR Related Orphan Receptor C Inhibitor
- (2019) Po-Chang Chiang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- First-Principles and Empirical Approaches to Predicting In Vitro Dissolution for Pharmaceutical Formulation and Process Development and for Product Release Testing
- (2019) Nikolay Zaborenko et al. AAPS Journal
- Exploring Multicompartment Plug Flow–Based Model Approach in Biopharmaceutics: Impact of Stomach Setting and the Estimation of the Fraction Absorbed of Orally Administered Basic Drugs
- (2019) Po-Chang Chiang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study
- (2018) Maximilian Sager et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Interindividual and intraindividual variability of fasted state gastric fluid volume and gastric emptying of water
- (2018) Michael Grimm et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Exploring a Kinetic Model Approach in Biopharmaceutics: Estimating the Fraction Absorbed of Orally Administered Drugs in Humans
- (2018) Po-Chang Chiang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Assessment of Passive Intestinal Permeability Using an Artificial Membrane Insert System
- (2018) Philippe Berben et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms
- (2016) Miriam Verwei et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Application and Validation of an Advanced Gastrointestinal In Vitro Model for the Evaluation of Drug Product Performance in Pharmaceutical Development
- (2014) Richard Barker et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Ibuprofen Sodium Is Absorbed Faster than Standard Ibuprofen Tablets: Results of Two Open-Label, Randomized, Crossover Pharmacokinetic Studies
- (2014) Thomas J. Legg et al. Drugs in research & development
- Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin
- (2013) Po-Chang Chiang et al. AAPS Journal
- In vitro models for the prediction of in vivo performance of oral dosage forms
- (2013) Edmund S. Kostewicz et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)
- (2013) David M. Ribnicky et al. FOOD CHEMISTRY
- In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
- (2013) Robert Havenaar et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Systemic Concentrations Can Limit the Oral Absorption of Poorly Soluble Drugs: An Investigation of Non-Sink Permeation Using Physiologically Based Pharmacokinetic Modeling
- (2013) Po-Chang Chiang et al. MOLECULAR PHARMACEUTICS
- Study on requirements of bioequivalence for registration of pharmaceutical products in USA, Europe and Canada
- (2013) Upendra C. Galgatte et al. SAUDI PHARMACEUTICAL JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now