Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain

Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem

(2023) Shahrzad Ghazisaeidi et al.   Annual Review of Pharmacology and Toxicology

Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

(2023) Véronik Lachance et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

(2023) Tianrui Zhang et al.   Brain and Behavior

Recent trends in chronic pain medicine

(2023) Naveen Malhotra et al.   Indian Journal of Anaesthesia

Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders

(2023) Dicson S. Malar et al.   CNS DRUGS

Microglia polarization in nociplastic pain: mechanisms and perspectives

(2023) Ahd A. Atta et al.   INFLAMMOPHARMACOLOGY

Roles of neuropathology-associated reactive astrocytes: a systematic review

(2023) Jill M. Lawrence et al.   Acta Neuropathologica Communications

The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain

(2023) Aidan McGinnis et al.   Cells

Microglial diversity in neuropathic pain

(2023) Makoto Tsuda et al.   TRENDS IN NEUROSCIENCES

Endoplasmic reticulum–mitochondria signaling in neurons and neurodegenerative diseases

(2022) Andrea Markovinovic et al.   JOURNAL OF CELL SCIENCE

Connexin43 inhibition attenuated dopaminergic neuronal loss in the lipopolysaccharide-induced mice model of Parkinson’s disease

(2022) Yujia Zhao et al.   NEUROSCIENCE LETTERS

Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain

(2022) Nunzio Vicario et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A spinal microglia population involved in remitting and relapsing neuropathic pain

(2022) Keita Kohno et al.   SCIENCE

Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-α-Necroptosis Pathway

(2022) Yi-Wen Duan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain

(2022) Rita Turnaturi et al.   MOLECULES

The Role of Microglia in Neuroinflammation of the Spinal Cord after Peripheral Nerve Injury

(2022) Tana S. Pottorf et al.   Cells

Connexins Signatures of the Neurovascular Unit and Their Physio-Pathological Functions

(2022) Nunzio Vicario et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GJA1/CX43 High Expression Levels in the Cervical Spinal Cord of ALS Patients Correlate to Microglia-Mediated Neuroinflammatory Profile

(2022) Nunzio Vicario et al.   Biomedicines

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions

(2021) Paloma A. Harcha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in the treatment of neuropathic pain

(2021) Nadine Attal et al.   CURRENT OPINION IN NEUROLOGY

Common and discrete mechanisms underlying chronic pain and itch: peripheral and central sensitization

(2021) Chengjin Li et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing

(2021) Nunzio Vicario et al.   Cell Death & Disease

Astroglial Connexins in Neurodegenerative Diseases

(2021) Xiaomin Huang et al.   Frontiers in Molecular Neuroscience

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

(2021) Richa Aishwarya et al.   Frontiers in Physiology

Dysregulation of Blood-Brain Barrier and Exacerbated Inflammatory Response in Cx47-Deficient Mice after Induction of EAE

(2021) Filippos Stavropoulos et al.   Pharmaceuticals

The σ1 Receptor and the HINT1 Protein Control α2δ1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain

(2021) María Rodríguez-Muñoz et al.   Biomolecules

Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist

(2020) Rita Turnaturi et al.   ACS Chemical Neuroscience

Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss

(2020) Federica Maria Spitale et al.   Aging-US

Intercellular communication and ion channels in neuropathic pain chronicization

(2020) Nunzio Vicario et al.   INFLAMMATION RESEARCH

Neuropathic pain: From mechanisms to treatment

(2020) Nanna Brix Finnerup et al.   PHYSIOLOGICAL REVIEWS

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis

(2020) Brienne A. McKenzie et al.   Journal of Neuroinflammation

Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity

(2020) Yuta Kohro et al.   NATURE NEUROSCIENCE

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

(2019) Nunzio Vicario et al.   MOLECULAR NEUROBIOLOGY

Disruption of ER−mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis

(2018) Dawn H. W. Lau et al.   Cell Death & Disease

(+)-and (−)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects

(2017) O. Prezzavento et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets

(2017) Nunzio Vicario et al.   Frontiers in Physiology

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain

(2016) Nunzio Vicario et al.   Molecular Pain

Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice

(2016) Sheu-Ran Choi et al.   NEUROPHARMACOLOGY

Intrathecal Therapy for Cancer-Related Pain

(2016) Brian M. Bruel et al.   PAIN MEDICINE

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression

(2015) Yuan Zhang et al.   Journal of Neuroinflammation

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

(2015) Yuta Kohro et al.   Scientific Reports

Best Practices for Intrathecal Drug Delivery for Pain

(2014) Joshua Prager et al.   NEUROMODULATION

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia

(2014) E Kavanagh et al.   Cell Death & Disease

Sigma 1 receptor: A new therapeutic target for pain

(2013) Daniel Zamanillo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

 2 -1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage

(2013) R. Patel et al.   JOURNAL OF NEUROSCIENCE

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization

(2012) L Romero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

(2012) Annette C. Dolphin   NATURE REVIEWS NEUROSCIENCE

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands

(2009) E. Cobos et al.   Current Neuropharmacology

The pharmacology of sigma-1 receptors

(2009) Tangui Maurice et al.   PHARMACOLOGY & THERAPEUTICS

When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

(2009) T.-P. Su et al.   Science Signaling

Nuclear translocation of endonuclease G in degenerating neurons after permanent middle cerebral artery occlusion in mice

(2009) Marianne Nielsen et al.   EXPERIMENTAL BRAIN RESEARCH

Intrathecal Injection of the ς1 Receptor Antagonist BD1047 Blocks Both Mechanical Allodynia and Increases in Spinal NR1 Expression during the Induction Phase of Rodent Neuropathic Pain

(2008) Dae-Hyun Roh et al.   ANESTHESIOLOGY

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE