Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation

(2019) Lorella Pasquinucci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

(2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist

(2019) Lorella Pasquinucci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits

(2018) Dong Wang et al.   NEURON

Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells

(2017) Nunzio Vicario et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

(2017) Raffaele Simeoli et al.   Nature Communications

Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets

(2017) Nunzio Vicario et al.   Frontiers in Physiology

Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy

(2016) Igor V. Manzhulo et al.   JOURNAL OF NEUROIMMUNOLOGY

Repeated activation of delta opioid receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain

(2016) Nunzio Vicario et al.   Molecular Pain

The Effectiveness and Risks of Long-Term Opioid Therapy for Chronic Pain: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop

(2015) Roger Chou et al.   ANNALS OF INTERNAL MEDICINE

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Recent advances on the δ opioid receptor: from trafficking to function

(2014) Louis Gendron et al.   BRITISH JOURNAL OF PHARMACOLOGY

Opioid receptor trafficking and interaction in nociceptors

(2014) X Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats

(2014) Ning Shen et al.   CNS Neuroscience & Therapeutics

Hemichannels: new roles in astroglial function

(2014) Juan A. Orellana et al.   Frontiers in Physiology

Identification of a Novel Spinal Dorsal Horn Astroglial D-Amino Acid Oxidase–Hydrogen Peroxide Pathway Involved in Morphine Antinociceptive Tolerance

(2013) Nian Gong et al.   ANESTHESIOLOGY

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation

(2013) Carmela Parenti et al.   INFLAMMATION RESEARCH

Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain

(2013) Alexander T. Podolsky et al.   LIFE SCIENCES

The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures

(2013) Carmela Parenti et al.   NEUROPHARMACOLOGY

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

(2012) Michael V.L. Bennett et al.   BRAIN RESEARCH

Heterosynaptic long-term depression mediated by ATP released from astrocytes

(2012) Jiadong Chen et al.   GLIA

Role of Astrocytes in Pain

(2012) C.-Y. Chiang et al.   NEUROCHEMICAL RESEARCH

Mechanisms of neuropathic pain

(2011) Florian T. Nickel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia

(2011) Claire Gaveriaux-Ruff et al.   PAIN

The delta opioid receptor: an evolving target for the treatment of brain disorders

(2011) Amynah A. Pradhan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity

(2010) Rosalba Parenti et al.   GLIA

In Vivo Characterization of MMP-2200, a Mixed  /  Opioid Agonist, in Mice

(2010) J. J. Lowery et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

(2010) Nicolas Froger et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Gi/o-Coupled Receptors Compete for Signaling to Adenylyl Cyclase in SH-SY5Y Cells and Reduce Opioid-Mediated cAMP Overshoot

(2010) E. S. Levitt et al.   MOLECULAR PHARMACOLOGY

Expression of connexin57 in mouse development and in harmaline-tremor model

(2010) A. Zappalà et al.   NEUROSCIENCE

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

(2009) Gianfranco Balboni et al.   ACS Chemical Neuroscience

Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

(2009) N. Dietis et al.   BRITISH JOURNAL OF ANAESTHESIA

Opioid-receptor-heteromer-specific trafficking and pharmacology

(2009) Richard M van Rijn et al.   CURRENT OPINION IN PHARMACOLOGY

Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels

(2009) Juan A. Orellana et al.   GLIA

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

(2008) Juan A. Orellana et al.   ANTIOXIDANTS & REDOX SIGNALING

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

(2008) Michael Cronin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Hyperglycaemia inhibits Schwann cell proliferation and migration and restricts regeneration of axons and Schwann cells from adult murine DRG

(2007) Laura F. Gumy et al.   MOLECULAR AND CELLULAR NEUROSCIENCE