Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection

Pridopidine modifies disease phenotype in a SOD1 mouse model of amyotrophic lateral sclerosis

(2022) Héctor M. Estévez‐Silva et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway

(2022) Fuhui Meng et al.   Nature Communications

Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain

(2021) Shao-Ming Wang et al.   MOLECULAR NEUROBIOLOGY

Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases

(2021) Vladimir Zhemkov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pridopidine reduces mutant huntingtin‐induced endoplasmic reticulum stress by modulation of the Sigma‐1 receptor

(2021) Marina Shenkman et al.   JOURNAL OF NEUROCHEMISTRY

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

(2021) Vladimir Zhemkov et al.   eLife

Pridopidine for the Improvement of Motor Function in Patients With Huntington's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2021) Shujun Chen et al.   Frontiers in Neurology

Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

(2021) Richa Aishwarya et al.   Frontiers in Physiology

ER-Phagy: A New Regulator of ER Homeostasis

(2021) Ming Yang et al.   Frontiers in Cell and Developmental Biology

Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish

(2021) Lucie Crouzier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes

(2021) Chowdhury S. Abdullah et al.   MITOCHONDRION

Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders

(2021) Kinga Sałaciak et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Endoplasmic Reticulum Membrane and Contact Site Dynamics in Autophagy Regulation and Stress Response

(2020) Etienne Morel   Frontiers in Cell and Developmental Biology

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy

(2020) Ming Yang et al.   Frontiers in Cell and Developmental Biology

Knocking Out Sigma-1 Receptors Reveals Diverse Health Problems

(2020) Simon Couly et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sigma-2 Receptor—A Potential Target for Cancer/Alzheimer’s Disease Treatment via Its Regulation of Cholesterol Homeostasis

(2020) Kai Yang et al.   MOLECULES

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

(2019) Maximilian Christ et al.   Cells

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model

(2019) Ariel Ionescu et al.   Cell Death & Disease

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson’s Disease

(2019) Veronica Francardo et al.   Neurotherapeutics

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Sigma-1 receptor ablation impairs autophagosome clearance

(2019) Huan Yang et al.   Autophagy

The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host–Pathogen Interactions and Innate Immunity

(2019) Tim Van Acker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulating G protein-coupled receptors by topological inversion

(2019) Bray Denard et al.   eLife

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

(2019) Chelsy R. Eddings et al.   NEUROBIOLOGY OF DISEASE

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

(2019) Daniel A. Ryskamp et al.   Frontiers in Neuroscience

Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion

(2019) Yoki Nakamura et al.   eLife

The Sigma-1 Receptor: When Adaptive Regulation of Cell Electrical Activity Contributes to Stimulant Addiction and Cancer

(2019) Olivier Soriani et al.   Frontiers in Neuroscience

ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome

(2019) Walter E. Kaufmann et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Imaging sigma receptors in the brain: New opportunities for diagnosis of Alzheimer’s disease and therapeutic development

(2018) Hongmei Jia et al.   NEUROSCIENCE LETTERS

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis for σ1 receptor ligand recognition

(2018) Hayden R. Schmidt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis

(2017) M Gueguinou et al.   ONCOGENE

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation

(2017) Ling Qi et al.   TRENDS IN CELL BIOLOGY

APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus

(2017) Timur Mavylutov et al.   Protein & Cell

Loss-of-function mutations in theSIGMAR1gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+signalling

(2016) Elisa Gregianin et al.   HUMAN MOLECULAR GENETICS

Sigma1 receptors inhibit store-operated Ca 2+ entry by attenuating coupling of STIM1 to Orai1

(2016) Shyam Srivats et al.   JOURNAL OF CELL BIOLOGY

Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix

(2016) Qiuyue Chen et al.   MOLECULAR CELL

Crystal structure of the human σ1 receptor

(2016) Hayden R. Schmidt et al.   NATURE

The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems

(2016) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Form Follows Function: The Importance of Endoplasmic Reticulum Shape

(2015) L.M. Westrate et al.   Annual Review of Biochemistry

Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria

(2015) Nino Natsvlishvili et al.   BMC BIOCHEMISTRY

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model

(2015) Ferdinando Squitieri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis

(2015) Martin Haslbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease

(2015) Yasuo Miki et al.   NEUROBIOLOGY OF DISEASE

Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope

(2015) Shang-Yi A. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Subcellular Localization of the Sigma-1 Receptor in Retinal Neurons — an Electron Microscopy Study

(2015) Timur A. Mavlyutov et al.   Scientific Reports

Dysregulation of protein trafficking in neurodegeneration

(2014) Xin Wang et al.   Molecular Neurodegeneration

Quality control of inner nuclear membrane proteins by the Asi complex

(2014) O. Foresti et al.   SCIENCE

Lipids and topological rules governing membrane protein assembly

(2013) Mikhail Bogdanov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Concise Guide to PHARMACOLOGY 2013/14: Overview

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases

(2013) Yasuo Miki et al.   NEUROPATHOLOGY

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

The role of small GTPases in neuronal morphogenesis and polarity

(2012) Christian Gonzalez-Billault et al.   Cytoskeleton

The Lifetime of UDP-galactose:Ceramide Galactosyltransferase Is Controlled by a Distinct Endoplasmic Reticulum-associated Degradation (ERAD) Regulated by Sigma-1 Receptor Chaperones

(2012) Teruo Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative

(2010) Vanessa Villard et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Detergent-Resistant Microdomains Determine the Localization of  -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

(2010) T. Hayashi et al.   MOLECULAR PHARMACOLOGY

Rac1 GTPase: A “Rac” of All Trades

(2009) E. E. Bosco et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

(2009) Shang-Yi Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY